A5034361476- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- vaccines and immunoinformatics approaches
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Research Studies
- Protein Degradation and Inhibitors
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- Chemokine receptors and signaling
- Chronic Lymphocytic Leukemia Research
University of Bern
2016-2025
University Hospital of Bern
2016-2025
University of Zurich
2000-2021
University Hospital of Basel
2021
Swiss Group For Clinical Cancer Research
2021
ETH Zurich
2016
Bipar
2012-2013
National Center for Tumor Diseases
2013
University of Lausanne
2010
University Hospital of Lausanne
2010
Natural antibodies are often dismissed from immunological analysis as “background,” but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or Listeria monocytogenes , viral bacterial titers peripheral organs, including the kidney and brain, were 10 to 100 times greater than antibody-competent (and enhanced their susceptibility some infections), secondary lymphoid organs lower mice. Thus, natural a crucial by...
Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve targets for immune effector T cells. Nevertheless, overall surveillance against seems relatively inefficient. We studied a s.c. sarcoma expressing characterized viral tumor antigen. Surprisingly, the cells were capable of inducing protective cytotoxic cell response if transferred single-cell suspension. However, they transplanted small pieces, readily grew. Tumor growth correlated...
Purpose Invasion and migration are key processes of glioblastoma tightly linked to tumor recurrence. Integrin inhibition using cilengitide has shown synergy with chemotherapy radiotherapy in vitro promising activity recurrent glioblastoma. This multicenter, phase I/IIa study investigated the efficacy safety combination standard chemoradiotherapy newly diagnosed Patients Methods (age ≥ 18 ≤ 70 years) were treated (500 mg) administered twice weekly intravenously addition concomitant adjuvant...
For patients with resectable stage IIIA(N2) non-small-cell lung cancer, neoadjuvant chemotherapy cisplatin and docetaxel followed by surgery resulted in a 1-year event-free survival (EFS) rate of 48% the SAKK 16/00 trial is an accepted standard care. We investigated additional benefit perioperative treatment durvalumab.Neoadjuvant consisted three cycles 100 mg/m2 85 once every 3 weeks two doses durvalumab 750 mg 2 weeks. Durvalumab was continued for 1 year after surgery. The primary end...
Abstract Neutropenia is probably the strongest known predisposition to infection with otherwise harmless environmental or microbiota-derived species. Because initial swarming of neutrophils at site occurs within minutes, rather than hours required induce “emergency granulopoiesis,” relevance having high numbers these cells available any one time obvious. We observed that germ-free (GF) animals show delayed clearance an apathogenic bacterium after systemic challenge. In this article, we size...
Abstract FTY720 (2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol hydrochloride) prolongs survival of solid organ allografts in animal models. Mechanisms immunomodulation were studied mice infected with lymphocytic choriomeningitis virus (LCMV) to assess T cell responses or vesicular stomatitis evaluate Ab responses. Oral (0.3 mg/kg/day) did not affect LCMV replication and specific CTL B cells induced expanded normally. Moreover, the anti-viral humoral immune normal. However, treatment...
Vaccination with dendritic cells (DCs) presenting tumor antigens induces primary immune response or amplifies existing cytotoxic antitumor T cell responses. This study documents that treatment DCs may cause severe autoimmune disease when the are not tumor-specific but also expressed in peripheral nonlymphoid organs. Growing tumors such shared were, at least initially, strictly located outside of secondary lymphoid organs were successfully controlled by specific DC vaccination. However, was...
Memory is a hallmark of immunity. carried by antibodies largely responsible for protection against reinfection with most known acutely lethal infectious agents and the basis clinically successful vaccines. However, nature long-term B cell antibody memory still unclear. was studied here after infection mice rabies-like cytopathic vesicular stomatitis virus, noncytopathic lymphocytic choriomeningitis virus (Armstrong WE), immunization various inert viral antigens inducing naive cells to...
Abstract Signaling of the TNF receptor superfamily member CD27 activates costimulatory pathways to elicit T- and B-cell responses. signaling is regulated by expression its ligand CD70 on subsets dendritic cells lymphocytes. Here, we analyzed role CD27–CD70 interaction in immunologic control solid tumors Cd27-deficient mice. In tumor-bearing wild-type mice, increased frequency regulatory T (Tregs), reduced tumor-specific T-cell responses, angiogenesis, promoted tumor growth. apoptosis Tregs...
Aberrant proliferation, symmetric self-renewal, increased survival, and defective differentiation of malignant blasts are key oncogenic drivers in acute myeloid leukemia (AML). Stem cell gene signatures predict poor prognosis AML patients; however, with few exceptions, these deregulated molecular pathways cannot be targeted therapeutically. In this study, we demonstrate that the TNF superfamily ligand–receptor pair CD70/CD27 is expressed on stem/progenitor cells. signaling cells activates...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune reactions. While TREM-1-amplified responses likely aid an improved detection and elimination pathogens, excessive production cytokines oxygen radicals can also severely harm the host. Studies addressing pathogenic role TREM-1 during endotoxin-induced shock or microbial sepsis have so far mostly relied administration fusion proteins peptides representing part extracellular domain...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune responses, but its significance in non-infectious diseases remains unclear. Here, we demonstrate that TREM-1 promotes cardiovascular disease by exacerbating atherosclerosis. advanced human atheromas and highly upregulated under dyslipidemic conditions circulating lesion-infiltrating cells the Apoe-/- mouse model. strongly contributes to high-fat, high-cholesterol diet...
Cusatuzumab is a high-affinity, anti-CD70 monoclonal antibody under investigation in acute myeloid leukemia (AML). This two-part, open-label, multicenter, phase I/II trial evaluated cusatuzumab plus azacitidine patients with newly diagnosed AML ineligible for intensive chemotherapy. Patients received single dose of at one four levels (1, 3, 10, or 20 mg/kg) 14 days before starting combination therapy. In I escalation, was then administered on 3 and 17, (75 mg/m2) 1-7, every 28 days. The...
Glioblastoma is the most common and aggressive malignant primary brain tumor in adults. cells synthesize secrete large quantities of excitatory neurotransmitter glutamate, driving epilepsy, neuronal death, growth invasion. Moreover, networks interconnect with glioblastoma cell through glutamatergic neuroglial synapses, activation which induces oncogenic calcium oscillations that are propagated via gap junctions between cells. The objective this study to explore efficacy brain-penetrating...
Complement is part of the innate immune system and one first lines host defense against infections. Its importance was evaluated in this study virus infections mice deficient either soluble complement factors (C3−/−, C4−/−) or signaling complex (complement receptor [CR]2−/−, CD19−/−). The induction initial T cell–independent neutralizing immunoglobulin (Ig)M antibody response to vesicular stomatitis (VSV), poliomyelitis virus, recombinant vaccinia depended on efficient antigen trapping by...