A5072335941- CAR-T cell therapy research
- Ultrasound and Hyperthermia Applications
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immune cells in cancer
- Cardiac Imaging and Diagnostics
- Acute Myeloid Leukemia Research
- Single-cell and spatial transcriptomics
- Cardiac Valve Diseases and Treatments
- Disaster Management and Resilience
- Cancer Genomics and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Public Relations and Crisis Communication
- Cancer Immunotherapy and Biomarkers
- Photoacoustic and Ultrasonic Imaging
- Epigenetics and DNA Methylation
- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Complex Network Analysis Techniques
- Chromatin Remodeling and Cancer
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Ultrasound and Cavitation Phenomena
The University of Texas MD Anderson Cancer Center
2017-2025
Renmin Hospital of Wuhan University
2016-2025
Wuhan University
2016-2025
University of Hong Kong
2016-2025
Chinese University of Hong Kong
2025
Soochow University
2025
University of South China
2024
University of Science and Technology Beijing
2022-2024
Shenyang University of Technology
2024
Central South University
2021-2024
BackgroundA novel coronavirus disease (COVID-19) in Wuhan has caused an outbreak and become a major public health issue China great concern from international community. Myocarditis myocardial injury were suspected may even be considered as one of the leading causes for death COVID-19 patients. Therefore, we focused on condition heart, sought to provide firsthand evidence whether myocarditis by COVID-19.MethodsWe enrolled patients with confirmed diagnosis retrospectively collected...
Abstract Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated sera of most newly diagnosed acute myeloid leukemia (AML) patients, complex interplay AML remains insufficiently understood. We aim to characterize these interactions through comprehensive bulk single-cell approaches bone marrow patients. identify monocytic as having unique microenvironment characterized by...
B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common B-NHL, such as diffuse large lymphoma, have been comprehensively interrogated at the genomic level, but rarer subtypes, mantle cell remain less extensively characterized. Furthermore, B-NHL thus far not compared using same methodology to identify conserved or subtype-specific patterns alterations. Here, we employed a targeted...
Patients with relapsed or refractory large B-cell lymphomas (rrLBCL) can achieve long-term remission after CD19 chimeric antigen receptor T-cell therapy (CART19). However, more than half of recipients will experience treatment failure. Thus, approaches are needed to identify high-risk patients who may benefit from alternative consolidative therapy. We evaluated low-pass whole-genome sequencing (lpWGS) cell-free DNA (cfDNA) before CART19 as a new approach for risk stratification. performed...
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive chromatin accessibility and transcriptional activation. among most recurrently mutated genes human cancer, including ∼30% germinal center (GC)-derived Burkitt lymphomas. In mice, GC-specific Smarca4 haploinsufficiency cooperated with MYC over-expression lymphomagenesis. Furthermore, monoallelic deletion drove GC hyperplasia...
Abstract Background Prostate cancer (PCa) is the leading cause of cancer-related morbidity and mortality in men worldwide. An early accurate diagnosis crucial for effective treatment prognosis. Traditional invasive procedures such as image-guided prostate biopsy often discomfort complications, deterring some patients from undergoing these necessary tests. This study aimed to explore feasibility clinical value using ultrasound super-resolution imaging (US SRI) non-invasively assessing...
Abstract Background Diabetic foot ulcers (DFUs) represent a major complication of diabetes, often leading to poor healing outcomes with conventional treatments. Mesenchymal stem cell (MSC) therapies have emerged as promising alternative, given their potential modulate various pathways involved in wound healing. This study evaluates and compares the therapeutic MSCs derived from perinatal tissues—human umbilical cord (hUCMSCs), human chorionic villi (hCVMSCs), decidua basalis (hDCMSCs)—in...
Abstract The E2F family member of transcription factors includes the atypical E2F8, which has been little studied in cancer. We report that E2F8 is strongly upregulated human hepatocellular carcinoma (HCC), where it was evidenced to contribute oncogenesis and progression. Ectopic overexpression promoted cell proliferation, colony formation, tumorigenicity, whereas knockdown inhibited these phenotypes, as documented Huh-7, Focus, Hep3B, YY-8103 HCC lines. Mechanistic analyses indicated could...
The activated B cell (ABC-like) subtype of diffuse large lymphoma (DLBCL) is characterized by chronic activation signaling initiated immunoglobulin μ (IgM). By analyzing the DNA copy number profiles 1000 DLBCL tumors, we identified gains 18q21.2 as most frequent genetic alteration in ABC-like DLBCL. Using integrative analysis matched gene expression profiling data, found that TCF4 (E2-2) transcription factor was target these alterations. Overexpression lines led to its occupancy on (IGHM)...
Autologous anti-CD19 chimeric antigen receptor T cell (CAR T) therapy is highly effective in relapsed/refractory large B lymphoma (rrLBCL) but associated with toxicities that delay recovery. While the biological mechanisms of cytokine release syndrome and neurotoxicity have been investigated, pathophysiology poorly understood for prolonged cytopenia, defined as grade ≥3 cytopenia lasting beyond 30 days after CAR infusion. We performed single-cell RNA sequencing bone marrow samples from...
Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling from 3 healthy bone marrow donors and 23 newly diagnosed (NewlyDx) 8 relapsed/refractory (RelRef) AML patients. Cells co-expressing canonical exhaustion markers formed a cluster constituting <1% all cells. We identified two effector cell subsets characterized by distinct cytokine...
Objectives Coronavirus disease 2019 (COVID‐19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has become a global pandemic, raising widespread public health concerns. Our team treated hospitalized patients with COVID‐19 in Wuhan, where outbreak first began, and we suspected that SARS‐CoV‐2 may cause testicular infection male patients. We conducted this study to explore observation. Methods enrolled confirmed diagnosis of performed bedside ultrasound (US)...
Due to the frequent occurrence of multi-hazard disasters worldwide in recent years, effective scenario analysis is imperative for disaster rescue and emergency management. The response procedure different single hazards were investigated formulated before. However, investigations rarely systematically address entire development process multi-hazards, including coupling mechanisms, evolution dynamics, assessment response. To this end, paper presents our methodology that integrates...