A5026939161- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and B-cell Immunology
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Research in Cotton Cultivation
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Curcumin's Biomedical Applications
The University of Texas MD Anderson Cancer Center
2004-2025
Harbin Institute of Technology
2024
Inner Mongolia University
2024
Agency for Science, Technology and Research
2024
Lymphoma Research Foundation
2022
Xi'an University of Technology
2021
Pennsylvania State University
2021
Peking University
2005-2020
University of Houston
2015-2018
China Pharmaceutical University
2007-2016
Resistin may be associated with obesity and cardiovascular diseases. However, it is unknown whether resistin directly contributes to angiogenesis. In the present study, we evaluated effects of on angiogenic potential, including endothelial cell proliferation, migration, capillary-like tube formation.Human coronary artery cells (HCAECs) were treated resistin. Cell proliferation was by [3H]thymidine incorporation MTS assays. migration assessed a modified Boyden chamber assay. Capillary-like...
CREBBP mutations are highly recurrent in B-cell lymphomas and either inactivate its histone acetyltransferase (HAT) domain or truncate the protein. Herein, we show that these two classes of yield different degrees disruption epigenome, with HAT being more severe associated inferior clinical outcome. Genes perturbed by mutation direct targets BCL6-HDAC3 onco-repressor complex. Accordingly, HDAC3-selective inhibitors reverse CREBBP-mutant aberrant epigenetic programming, resulting in: (i)...
B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common B-NHL, such as diffuse large lymphoma, have been comprehensively interrogated at the genomic level, but rarer subtypes, mantle cell remain less extensively characterized. Furthermore, B-NHL thus far not compared using same methodology to identify conserved or subtype-specific patterns alterations. Here, we employed a targeted...
Patients with relapsed or refractory large B-cell lymphomas (rrLBCL) can achieve long-term remission after CD19 chimeric antigen receptor T-cell therapy (CART19). However, more than half of recipients will experience treatment failure. Thus, approaches are needed to identify high-risk patients who may benefit from alternative consolidative therapy. We evaluated low-pass whole-genome sequencing (lpWGS) cell-free DNA (cfDNA) before CART19 as a new approach for risk stratification. performed...
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive chromatin accessibility and transcriptional activation. among most recurrently mutated genes human cancer, including ∼30% germinal center (GC)-derived Burkitt lymphomas. In mice, GC-specific Smarca4 haploinsufficiency cooperated with MYC over-expression lymphomagenesis. Furthermore, monoallelic deletion drove GC hyperplasia...
Kinases are critical regulators of cellular function that commonly implicated in the mechanisms underlying disease. Most drugs target kinases molecules inhibit their catalytic activity, but here we used chemically induced proximity to convert kinase inhibitors into activators therapeutic genes. We synthesized bivalent link ligands transcription factor B cell lymphoma 6 (BCL6) cyclin-dependent (CDKs). These relocalized CDK9 BCL6-bound DNA and directed phosphorylation RNA polymerase II. The...
SMXZF is a combination of Rb1, Rg1, schizandrin, and DT‐13 (6:9:5:4) derived from Sheng‐mai San, widely used Chinese traditional medicine for the treatment cardiovascular cerebral diseases. The present study explores inhibitory effects signaling pathways on autophagy induced by ischemia–reperfusion injury. Male C57BL/6 mice were subjected to insult right middle artery occlusion (MCAO) 1 hr with subsequent 24 reperfusion. Three doses (4.5, 9, 18 mg/kg) administered intraperitoneally (i.p.)...
Autologous anti-CD19 chimeric antigen receptor T cell (CAR T) therapy is highly effective in relapsed/refractory large B lymphoma (rrLBCL) but associated with toxicities that delay recovery. While the biological mechanisms of cytokine release syndrome and neurotoxicity have been investigated, pathophysiology poorly understood for prolonged cytopenia, defined as grade ≥3 cytopenia lasting beyond 30 days after CAR infusion. We performed single-cell RNA sequencing bone marrow samples from...
Context Shengmai injection (SMI) is a patented Chinese medicine originated from the ancient herbal compound san, which used extensively for treatment of cardiovascular and cerebrovascular disease in clinic.Objective To determine neuroprotective effect SMI, we investigated SMI on cerebral ischemia/reperfusion (I/R) injury mice as well mechanisms underlying this effect.Materials methods Right middle artery was occluded by inserting thread through internal carotid 1 h, then reperfused 24 h...
Developing cancer therapies that induce robust death of the malignant cell is critical to prevent relapse. Highly effective strategies, such as immunotherapy, exemplify this observation. Here we provide structural and molecular underpinnings for an approach leverages chemical induced proximity produce specific killing diffuse large B lymphoma, most common non-Hodgkin's lymphoma. We develop KAT-TCIPs (lysine acetyltransferase transcriptional/epigenetic inducers proximity) redirect p300 CBP...
Over the last 20 years, intensive research has been focused on specific mechanisms mediating pancreatic β-cell injury. Both decreased viability and dysfunction of β-cells have become key factors in development diabetes mellitus. Thus, it is utmost importance to elucidate discrete pathological changes within context various lipotoxicity models. The goal these studies generate evidence improve not only clinical treatment for diabetics, but also modulate diet activities groups at high risk...
Abstract Lung carcinogenesis is a complex process that occurs in unregulated inflammatory environment. EGCG has been extensively investigated as multi-targeting anti-tumor and anti-inflammatory compound. In this study, we demonstrated novel mechanism by which reverses the neutrophil elastase-induced migration of A549 cells. We found elastase directly triggered human adenocarcinoma cell suppressed elevation tumor induced elastase. observed binds to inhibits its enzymatic activity based on...
Abstract Richter Transformation (RT) develops in CLL as an aggressive, therapy-resistant, diffuse large B cell lymphoma (RT-DLBCL), commonly clonally-related (CLR) to the concomitant CLL. Lack of available pre-clinical human models has hampered development novel therapies for RT-DLBCL. Here, we report profiles genetic alterations, chromatin accessibility and active enhancers, gene-expressions anti-lymphoma drug-sensitivity three newly established, patient-derived, xenograft (PDX) RT-DLBCLs,...