A5061323862- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Cancer-related gene regulation
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Advanced Clustering Algorithms Research
- Adversarial Robustness in Machine Learning
- Genetic factors in colorectal cancer
- Reinforcement Learning in Robotics
- Lung Cancer Treatments and Mutations
- Domain Adaptation and Few-Shot Learning
- Advanced Breast Cancer Therapies
- Pancreatic and Hepatic Oncology Research
- Personality Disorders and Psychopathology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Music and Audio Processing
Princess Alexandra Hospital
2016-2025
The University of Queensland
2016-2025
Mater Research
2019-2024
Translational Research Institute
2016-2024
Trinity College Dublin
2021-2023
Oak Ridge National Laboratory
2023
The University of Texas MD Anderson Cancer Center
2022
Retina Institute
2021
Diamant (Germany)
2021
Gold Coast Hospital
2020-2021
Dealing with sparse rewards is one of the biggest challenges in Reinforcement Learning (RL). We present a novel technique called Hindsight Experience Replay which allows sample-efficient learning from are and binary therefore avoid need for complicated reward engineering. It can be combined an arbitrary off-policy RL algorithm may seen as form implicit curriculum. demonstrate our approach on task manipulating objects robotic arm. In particular, we run experiments three different tasks:...
The purpose of this technical report is two-fold. First all, it introduces a suite challenging continuous control tasks (integrated with OpenAI Gym) based on currently existing robotics hardware. include pushing, sliding and pick & place Fetch robotic arm as well in-hand object manipulation Shadow Dexterous Hand. All have sparse binary rewards follow Multi-Goal Reinforcement Learning (RL) framework in which an agent told what to do using additional input. second part the paper presents set...
Understanding the immunobiology of 15% to 30% patients with follicular lymphoma (FL) who experience progression disease within 24 months (POD24) remains a priority. Solid tumors low levels intratumoral immune infiltration have inferior outcomes. It is unknown whether similar relationship exists between POD24 in FL.Digital gene expression using custom code set-five effector, six checkpoint, one macrophage molecules-was applied discovery cohort early- and advanced-stage FL (n = 132). T-cell...
Abstract Blockade of the PD-1 axis has modest efficacy in diffuse large B-cell lymphoma (DLBCL), but data regarding LAG3 are sparse. The impact digital gene expression was tested 309 patients with DLBCL treated standard chemoimmunotherapy. Cellular distribution protein determined by immunohistochemistry and flow cytometry. In tumor-infiltrating lymphocytes (TILs), highest on CD4+ regulatory T cells (Tregs) also highly expressed CD8+ compared non-Tregs (both P = .008). LAG3high TILs were...
B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common B-NHL, such as diffuse large lymphoma, have been comprehensively interrogated at the genomic level, but rarer subtypes, mantle cell remain less extensively characterized. Furthermore, B-NHL thus far not compared using same methodology to identify conserved or subtype-specific patterns alterations. Here, we employed a targeted...
Purpose: To investigate the relationship between intra-tumoral T-cell receptor (TCR) repertoire and tumor microenvironment (TME) in de novo diffuse large B-cell lymphoma (DLBCL) impact of TCR on survival.Experimental Design: We performed high-throughput unbiased TCRβ sequencing a population-based cohort 92 patients with DLBCL treated conventional (i.e., non-checkpoint blockade) frontline "R-CHOP" therapy. Key immune checkpoint genes within TME were digitally quantified by nanoString. The...
Tumor cells orchestrate their microenvironment. Here, we provide biochemical, structural, functional, and clinical evidence that Cathepsin S (CTSS) alterations induce a tumor-promoting immune microenvironment in follicular lymphoma (FL). We found CTSS mutations at Y132 6% of FL (19/305). Another 13% (37/286) had amplification, which was associated with higher expression. lead to accelerated autocatalytic conversion from an enzymatically inactive profrom active increased substrate cleavage,...
Abstract Objective Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV ‐pos DLBCL) is a recently identified entity. Data regarding outcome to frontline immuno‐chemotherapy are conflicting. Although the prognostic impact of tumour microenvironment (TME) in EBV ‐neg DLBCL well‐established, it remains untested whether TME influences survival DLBCL. There no data with new digital gene expression technologies that simultaneously interrogate virus, B cells and (TME). Methods We used...
Summary Epstein–Barr virus (EBV)‐associated lymphomas cover a range of histological B‐ and T‐cell non‐Hodgkin Hodgkin lymphoma subtypes. The role EBV on B‐cell malignant pathogenesis its impact the tumour microenvironment are intriguing but incompletely understood. Both International Consensus Classification (ICC) 5th Edition World Health Organization (WHO‐HAEM5) proposals give prominence to distinct clinical, prognostic, genetic microenvironmental features in lymphoproliferative disorders....
ABSTRACT Background The TROG 99.03 trial demonstrated improved progression‐free survival for patients with early‐stage follicular lymphoma (FL) treated systemic therapy using rituximab‐cyclophosphamide, vincristine, prednisolone (R‐CVP) after involved‐field radiotherapy (RT) versus RT. As was associated more acute toxicity, the possibility of long‐term and no benefit yet, cost‐effectiveness RT+R‐CVP is important. Aim We performed a analysis RT (reference), RT+CVP, from trial. Methods...
An unmet challenge in managing breast cancer is treatment failure due to resistance apoptosis-inducing chemotherapies. Thus, it important identify novel non-apoptotic therapeutic agents. Several programmed cell death pathways utilize specific cellular signaling events trigger lytic and pro-inflammatory death. PANoptosis, which encompasses pyroptosis, apoptosis necroptosis, of paramount importance the regulation immune responses. Our study illustrates that ophiobolin A (OpA) an anti-cancer...
We investigated the genetic cause of disease in five affected individuals from two unrelated families with an autosomal dominant pattern invasive Streptococcus pneumoniae infection associated a clinical phenotype specific antibody deficiency. In Family A, male siblings presented at <5 years sepsis due to S. pneumoniae. The father had history meningitis and recurrent pneumonias, female sibling less severe infections. B, during infancy no family immunodeficiency. All patients...
To test the utility of circulating Lactate Dehydrogenase (LDH) to absolute lymphocyte count (ALC) ratio (LAR) predict outcome conventional first-line chemo-immunotherapy in Diffuse Large B-cell Lymphoma (DLBCL), and investigate its correlation tumour immune microenvironment (TME).A population based cohort 210 patients (median age: 64, range 18-90 years) with median follow up 3.8 years was analysed. All were treated R-CHOP, no immunosuppression related cases included. Tissue for nanoString...
Management practices in early-stage (I/II) follicular lymphoma (FL) are variable and include radiation (RT), systemic therapy, or combined modality therapy (CMT). There is a paucity of data regarding maintenance rituximab this cohort. We conducted an international retrospective study patients with newly diagnosed FL staged positron emission tomography (PET)-computed bone marrow biopsy. Three hundred sixty-five (stage I, n = 221), median age 63 years, treated from 2005-2017 were included,...
Primary central nervous system lymphoma (PCNSL) occurring following organ transplantation (post-transplantation lymphoproliferative disorder [PTLD]) is a highly aggressive non-Hodgkin lymphoma. It typically treated with high-dose methotrexate-based regimens. Outcomes are dismal and clinical trials lacking. almost always Epstein–Barr virus (EBV) associated. Two patients (CA1-2) presented EBV-associated PCNSL after renal transplant. CA1 was on hemodialysis had prior disseminated cryptococcus...
Data on the prognostic impact of pretherapy 18F-fluorodeoxyglucose–positron emission tomography (FDG-PET) in follicular lymphoma (FL) is conflicting. The predictive utility total metabolic tumor volume (TMTV) and maximum standardized uptake value (SUVmax) outcome appears to vary between regimens. Chemoimmunotherapies extent T-cell depletion they induce. role intratumoral T cells FDG-PET parameters undefined. We assessed quantified by multiple methodologies. Low associated with approximately...
Density-based clustering methods have been shown to achieve promising results in modern data mining applications. A recent approach, Density Peaks Clustering (DPC), detects modes as points with high density and large distance of higher density, hence often fails detect low-density clusters the data. Furthermore, DPC has quadratic complexity. We here develop a new algorithm, aiming at improving applicability efficiency peak-finding technique. The improvements are threefold: (1) algorithm is...
Understanding the 3-dimensional structure of world is a core challenge in computer vision and robotics. Neural rendering approaches learn an implicit 3D model by predicting what camera would see from arbitrary viewpoint. We extend existing neural to more complex, higher dimensional scenes than previously possible. propose Epipolar Cross Attention (ECA), attention mechanism that leverages geometry scene perform efficient non-local operations, requiring only $O(n)$ comparisons per spatial...