A5076254352- Wound Healing and Treatments
- Curcumin's Biomedical Applications
- FOXO transcription factor regulation
- Pancreatic function and diabetes
- Diabetic Foot Ulcer Assessment and Management
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Ion Transport and Channel Regulation
- Cancer Genomics and Diagnostics
- Lipoproteins and Cardiovascular Health
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Ferroptosis and cancer prognosis
- Receptor Mechanisms and Signaling
- Fungal Biology and Applications
- Peptidase Inhibition and Analysis
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Pressure Ulcer Prevention and Management
- Electrolyte and hormonal disorders
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Advanced Glycation End Products research
- Metabolism, Diabetes, and Cancer
Peking University
2016-2025
China Medical University
2023
Xinjiang Medical University
2022
Food and Drug Administration
2012
State Key Laboratory of Natural and Biomimetic Drugs
2012
University of Chicago
2012
Tianjin Municipal Research Institute for Family Planning
2012
University of Pittsburgh
2009
VA Pittsburgh Healthcare System
2009
Michigan State University
2008
1. Curcumin is a naturally occurring poly-phenolic compound with broad range of favourable biological functions, including anti-cancer, anti-oxidant and anti-inflammatory activities. The low bioavailability in vivo stability curcumin require the development suitable carrier vehicles to deliver molecule sustained manner at therapeutic levels. 2. In present study, we investigated feasibility potential poly(caprolactone) (PCL) nanofibres as delivery vehicle for wound healing applications. By...
Our study first proposed that curcumin could protect human endothelial cells from the damage caused by oxidative stress via autophagy. Furthermore, our results revealed causes some novel cellular mechanisms promote autophagy as a protective effect. Pretreatment with remarkably improves survival of umbilical vein (HUVECs) H 2O 2-induced viability loss, which specifically evokes an autophagic response. Exposed to 2, curcumin-treated HUVECs upregulate level microtubule-associated protein 1...
Background and Purpose Growing evidence indicates targeting mitochondrial dynamics biogenesis could accelerate recovery from renal ischemia–reperfusion (I/R) injury, but the underlying mechanisms remain elusive. Transcription factor forkhead box O1 (FOXO1) is a key regulator of homeostasis plays pathological role in progression disease. Experimental Approach A mouse model I/R injury hypoxia/reoxygenation (H/R) for human tubular epithelial cells were used. Key Results up‐regulated expression...
Background/Aims. Refractory wounds in diabetic patients constitute a serious complication that often leads to amputation with limited treatment regimens. The present study was designed determine the protective effect of Ganoderma lucidum polysaccharide (Gl-PS) on wound healing and investigate underlying mechanisms. Methods. Streptozotocin (STZ)-induced type 1 mice full-thickness excisional were intragastrically administered 10, 50 or 250 mg/kg/day Gl-PS. Results. Gl-PS dose-dependently...
AimsThe purposes of the present study were to both evaluate protective effects Salvianolic acid B (Sal B) and determine possible molecular mechanisms by which Sal protects endothelial cells from damage caused oxidative stress.
Background Diuretic agents are widely used on the treatment of water retention related diseases, among which acetazolamide (AZA) acts originally as a carbonic anhydrase (CA) inhibitor. Aquaporin-1 (AQP1) being located in renal proximal tubules is required for urine concentration. Previously our lab has reported AZA putatively modulated AQP1. Aim this study to testify hypothesis that regulating AQP1 may mediate diuretic effect AZA. Methodology/Principal Findings For vivo study, we utilized...
MRGPRX1, a Mas-related GPCR (MRGPR), is key receptor for itch perception and targeting MRGPRX1 may have potential to treat both chronic pain. Here we report cryo-EM structures of the MRGPRX1-Gi1 MRGPRX1-Gq trimers in complex with two peptide ligands, BAM8-22 CNF-Tx2. These reveal shallow orthosteric pocket its conformational plasticity sensing multiple different peptidic allergens. Distinct from MRGPRX2, contains unique feature at extracellular ends TM3 TM4 accommodate C-terminal "RF/RY"...
To accomplish concerted physiological reactions, nature has diversified functions of a single hormone at least two primary levels: 1) Different receptors recognize the same hormone, and 2) different cellular effectors couple to hormone–receptor pair [R.P. Xiao, Sci STKE 2001 , re15 (2001); L. Hein, J. D. Altman, B.K. Kobilka, Nature 402 181–184 (1999); Y. Daaka, M. Luttrell, R. Lefkowitz, 390 88–91 (1997)]. Not only these questions lie in heart actions receptor signaling but also dissecting...
Refractory wound is a severe complication that leads to limb amputation in diabetes. Endothelial nitric oxide synthase (eNOS) plays key role normal repair but uncoupled streptozotocin (STZ)-induced type 1 diabetes because of reduced cofactor tetrahydrobiopterin (BH(4)). We tested the hypothesis overexpression GTP cyclohydrolase I (GTPCH I), rate-limiting enzyme for de novo BH(4) synthesis, retards NOS uncoupling and accelerates healing STZ mice. Blood glucose levels were significantly...
Torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor which raises high-density lipoprotein (HDL) cholesterol and reduces low-density (LDL) level, has been documented to increase mortality cardiac events associated with adverse effects. However, it is still unclear the underlying mechanisms of off-target effects torcetrapib.In present study, we developed systems biology approach by combining human reassembled signaling network publicly available microarray gene expression data...
Background/Aims: Aquaporin-1 (AQP1) is a glycoprotein that mediates osmotic water transport, its expression has been found to correlate with tumour stage in some tumours. However, the mechanism by which AQP1 protein regulated tumor cells remains be fully elucidated. We hypothesized hypoxia might play an important role induction during tumorigenesis and at late stages of development. Methods: Isotonic serum-free hypoxic models were used investigate PC-3M human prostate cancer cells. Results:...
Tumor metastasis is a major cause leading to the deaths of cancer patients. Nordihydroguaiaretic acid (NDGA) natural product that has been demonstrated show therapeutic values in multiple diseases. In this study, we report NDGA can inhibit cell migration and tumor via novel mechanism. suppresses NRP1 function by downregulating its expression, which leads attenuated motility, adhesion ECM FAK signaling cells. Moreover, due cross-cell type activity on suppression, also impairs angiogenesis...
Endothelial progenitor cell (EPC) dysfunction is a key contributor to diabetic refractory wounds. nitric oxide synthase (eNOS), which critically regulates the mobilization and function of EPCs, uncoupled in diabetes due decreased cofactor tetrahydrobiopterin (BH4). We tested whether GTP cyclohydrolase I (GTPCH I), rate-limiting enzyme BH4 synthesis, preserves EPC type 1 mice. Type was induced wild-type (WT) GTPCH transgenic (Tg-GCH) mice by intraperitoneal injection streptozotocin (STZ)....