A5068860723- Cognitive Radio Networks and Spectrum Sensing
- Advanced MIMO Systems Optimization
- Wireless Communication Networks Research
- Autoimmune Neurological Disorders and Treatments
- Cooperative Communication and Network Coding
- Genetics and Neurodevelopmental Disorders
- Mobile Ad Hoc Networks
- Blind Source Separation Techniques
- Bacterial Infections and Vaccines
- Indoor and Outdoor Localization Technologies
- Wireless Networks and Protocols
- Power Line Communications and Noise
- Ion channel regulation and function
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Neuroscience and Neuropharmacology Research
- Ubiquitin and proteasome pathways
- EEG and Brain-Computer Interfaces
- Microtubule and mitosis dynamics
- Mitochondrial Function and Pathology
- Attention Deficit Hyperactivity Disorder
- Ion Transport and Channel Regulation
- interferon and immune responses
- Receptor Mechanisms and Signaling
- Advanced Wireless Network Optimization
Yantai University
2012-2025
Zhejiang Lab
2025
Wenzhou Medical University
2025
Capital Institute of Pediatrics
2011-2025
National University of Defense Technology
2019-2025
Luye Pharma (China)
2014-2025
Luye Pharma (Switzerland)
2025
South China University of Technology
2023
Nanchang University
2023
First Affiliated Hospital of Nanchang University
2023
PFKFB3 (6-phosphofructo-2-kinase) synthesizes fructose 2,6-bisphosphate (F2,6P2), which is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), the rate-limiting enzyme glycolysis. Overexpression leads to high glycolytic metabolism, required for cancer cells survive in harsh tumor microenvironment. The objective this study was investigate antitumor activity PFK15 (1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one), a small molecule inhibitor PFKFB3, against gastric and explore its...
The application of metagenomic next-generation sequencing (mNGS) in the diagnosis tuberculous meningitis (TBM) remains poorly characterized. Here, we retrospectively analyzed data from patients with TBM who had taken both mNGS and conventional tests including culture Mycobacterium tuberculosis (MTB), polymerase chain reaction (PCR) acid-fast bacillus (AFB) stain, sensitivity specificity these methods were compared.We recruited admitted to hospital between December 2015 October 2018. first...
Abstract As a common and severe cerebrovascular disease, ischemic stroke casts significant shadow over global health. Unfortunately, the mechanisms regulating neuronal death in affected areas remain largely unclear. Here, we found that deletion of deubiquitinating enzyme Otubain-2 (OTUB2) significantly alleviated ischemia-induced cerebral infarction neurological deficits, accompanied by reduction loss, glial activation, neuroinflammation. OTUB2 was predominantly expressed neurons its...
Background and purpose: We retrospectively analyzed the clinical characteristics of children with autoimmune encephalitis (AE) in two Chinese tertiary pediatric neurology centers. also compared anti-NMDAR without co-positive MOG antibody, as well specific autoantibody positive AE autoantibody-negative but probable AE. Methods: A retrospective study (0–18 years old) Peking University First Hospital Children's Affiliated to Capital Institute Pediatrics was carried out from May 2012 January...
Background Diuretic agents are widely used on the treatment of water retention related diseases, among which acetazolamide (AZA) acts originally as a carbonic anhydrase (CA) inhibitor. Aquaporin-1 (AQP1) being located in renal proximal tubules is required for urine concentration. Previously our lab has reported AZA putatively modulated AQP1. Aim this study to testify hypothesis that regulating AQP1 may mediate diuretic effect AZA. Methodology/Principal Findings For vivo study, we utilized...
The purposes of this study are to investigate the antitumor activities NSK-01105, a novel sorafenib derivative, in vitro and vivo models, explore potential mechanisms. effects NSK-01105 on proliferation apoptosis prostate cancer cells were established by cytotoxicity assays, analysis, flow cytometry Western blot analysis. Two xenograft tumor models used verify therapeutic effect vivo. exhibited broad-spectrum activity, particularly cells. Characterization morphology was observed, percentage...
Probiotics adjuvant therapy might enhance the efficacy of conventional medications bipolar disorder type Ⅰ (BD-Ⅰ). A randomized double-blind placebo-controlled design was implemented in this study. We randomly assigned 98 patients with depressive BD-Ⅰ to receive combined treatment probiotics (Bifidobacterium animals subsp. lactis BAMA-B06/BAu-B0111, 2 g/day) (N = 49) and medications, or along placebo (maltodextrin, 49). Primary endpoints were change from baseline 30 days scores 17-item...
Cell cycle-dependent kinase 2 (CDK2) is located downstream of CDK4/6 in the cell cycle and regulates entry into S-phase by binding to Cyclin E hyper-phosphorylating Rb. Proto-oncogene murine double minute (MDM2) a key negative regulator p53, which highly expressed tumors plays an important role tumorigenesis progression. In this study, we identified dual inhibitor CDK2 MDM2, III-13, had good selectivity for inhibiting activity significantly reduced MDM2 expression. vitro results showed that...
The user-cell association mechanism is one of the important research topics for radio resource management in heterogeneous wireless networks. Existing studies mainly concerned physical performance such as throughput and SINR, ignore upper layer users demand. For avoiding blindness pursuing higher data rate achieving more rational association, a novel method proposed to associate with traffic small cell base stations (SBSs) based on user quality experience (QoE). problem formulated...
The clinical-stage agonists for trace amine-associated receptor 1 (TAAR1) show insufficient clinical efficacy, requiring the design of new compounds beyond TAAR1 alone. Here, we provide evidence feasibility designing TAAR1/5-HT2CR dual based on structural basis these two targets and similarities their agonists. Three series novel were discovered, leading to a potent compound named 21b. 21b exhibits submicromolar potency both 5-HT2CR with high specificity confirmed by site-directed...
Background/Aims: Acute kidney injury (AKI) is a major complication of transplantation, resulting in early graft dysfunction. Since diuretic acetazolamide (AZA) has been shown to improve contrast induced AKI, we hypothesized that AZA also protected against ischemia-reperfusion (I/R) caused AKI. Methods: An vivo mouse renal I/R model and an vitro H2O2 stimulated HK-2 cell were utilized examine the renoprotective effect AZA. Renal blood flow measured. Nitric oxide synthase (eNOS)/Nitric (NO),...
Currently, the occurrence and mortality rate of cervical cancer is high, particularly in low‑to‑middle‑income countries. Therefore, development novel diagnostic treatment strategies for urgently required. The aim present study was to assess prognostic significance fibronectin type III domain containing 3B (FNDC3B) expression patients with determine underlying mechanism FNDC3 tumor development. Analysis ONCOMINE database revealed that FNDC3B significantly upregulated tissue compared normal...
Radio maps can enhance the capability of wireless sensor networks and improve efficiency spectrum utilization. However, construction an accurate radio map in urban environment is a challenging task, since dense buildings lead to non-line-of-sight (NLOS) transmission environment. With this focus, we first transform spatial sparse measurement points into graph structure extract connected relation through building map. Then, propose neural network (GNN) scheme recover complete from...
The neuroprotective activity of pyruvate has been confirmed in previous vivo and vitro studies. Here, we report a novel mechanism that prevents SH-SY5Y cells from glutamate excitotoxicity by regulating death-associated protein kinase 1 (DAPK1) complex. Our results showed regulated DAPK1 complex to protect two ways. First, induced the dissociation with NMDA receptors. disruption DAPK1-NMDA receptors resulted decrease phosphorylation. Then glutamate-stimulated Ca2+ influx was inhibited...
Abstract PCC-0208027 is a novel tyrosine kinase inhibitor that has strong inhibitory effect on epidermal growth factor receptor (EGFR)- or HER2-driven cancers. The aim to assess the anti-tumor activity of PCC0208027 and related mechanisms in non-small cell lung cancer (NSCLC). We examined various mutated EGFRs, HER2, HER4. MTT assays, flow cytometry, Western blotting were used examine effects NSCLC cells with different genetic characteristics relevant molecular mechanisms. Nude mouse...
Cognitive radio enabled dynamic spectrum access is a promising solution to alleviate the low-utilization problem. Secondary users need sense bands before transmitting on them avoid collision with licensed users. To reduce delay and energy consumption of sensing, prediction incorporated predict future usage channels sensing. In this paper, three-step ahead framework designed based neutral network, which optimized by generic algorithm local optimization As it difficult obtain statistics...
The purpose of this study is to investigate the anti-angiogenic activities NSK-01105, a novel sorafenib derivative, in vitro, ex vivo and models, explore potential mechanisms. NSK-01105 significantly inhibited vascular endothelial growth factor (VEGF)-induced migration tube formation human umbilical vein cells at non-cytotoxic concentrations as shown by wound-healing, transwell cell assays, respectively. Cell viability invasion LNCaP PC-3 were cytotoxicity assay matrigel assay. Furthermore,...
Spectrum prediction estimates channel future status from history statistics, which greatly improved the efficiency of spectrum sensing in cognitive radio networks. Current researches mainly focus on improving speed and accuracy prediction. Few discuss energy-efficient design Since affect working hours transmission efficiency, that is an important performance metric for In this paper, we aspect energy-efficient. Numerical results have shown affected by strategy communication environment....