A5103818691- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Advanced Topology and Set Theory
- Limits and Structures in Graph Theory
- Respiratory viral infections research
- Gastric Cancer Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Congenital Diaphragmatic Hernia Studies
- Macrophage Migration Inhibitory Factor
- Neurogenesis and neuroplasticity mechanisms
- Advanced Graph Theory Research
- Pluripotent Stem Cells Research
- Chronic Lymphocytic Leukemia Research
- Essential Oils and Antimicrobial Activity
- Cancer-related gene regulation
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Heat shock proteins research
- Metastasis and carcinoma case studies
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
Luye Pharma (China)
2025
Luye Pharma (Switzerland)
2023-2025
Shanxi Medical University
2024
Wenzhou Medical University
2010-2024
Shenyang Agricultural University
2024
Anhui Medical University
2024
Hainan Medical University
2024
Jinan University
2024
Xi'an Chest Hospital
2023
Tsinghua University
2023
Abstract Background Ferroptosis is a recently recognized non-apoptotic cell death that distinct from the apoptosis, necroptosis and pyroptosis. Considerable studies have demonstrated ferroptosis involved in biological process of various cancers. However, role esophageal adenocarcinoma (EAC) remains unclear. This study aims to explore ferroptosis-related genes (FRG) expression profiles their prognostic values EAC. Methods The FRG data clinical information were downloaded Cancer Genome Atlas...
Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the DC mechanical sensor Piezo1 stimulated stiffness or inflammatory signals directs reciprocal differentiation of TH1 and regulatory (Treg) cancer. Genetic deletion DCs inhibited generation while driving development Treg promoting cancer growth mice. Mechanistically, Piezo1-deficient regulated secretion polarizing cytokines TGFβ1 IL-12, leading to increased...
Follicular helper T (TFH) cells are critical for germinal center (GC) formation and responsible effective B cell-mediated immunity; metabolic signaling is an important regulatory mechanism the differentiation of TFH cells. However, precise roles hypoxia inducible factor (HIF) 1α-dependent glycolysis oxidative phosphorylation (OXPHOS) remain unclear in cell differentiation. Herein, we investigated effects OXPHOS on GC responses using a pharmacological approach mice under steady immune status...
In endoscopic surgery, trocars impose kinematic constraints. Whenever a robot manipulates instruments, it needs to know the trocar location with respect its base frame. literature, this knowledge is acquired thanks an installation / registration procedure, prior operation. paper, we are considering comanipulation scenario: Both and surgeon hold instrument. All along instrument can be inserted into or removed from different by surgeon. It needed detect in real time whether compute fulcrum...
The therapeutic effects of glucocorticoids on colitis and colitis-associated cancer are unclear. In this study, we investigated the roles in acute experimental ulcerative mice their immunoregulatory mechanisms. Murine was induced by dextran sulfate sodium (DSS) treated with dexamethasone (Dex) at different doses. Dex significantly exacerbated onset severity DSS-induced potentiated mucosal inflammatory macrophage neutrophil infiltration, as well cytokine production. Furthermore, under...
The clinical-stage agonists for trace amine-associated receptor 1 (TAAR1) show insufficient clinical efficacy, requiring the design of new compounds beyond TAAR1 alone. Here, we provide evidence feasibility designing TAAR1/5-HT2CR dual based on structural basis these two targets and similarities their agonists. Three series novel were discovered, leading to a potent compound named 21b. 21b exhibits submicromolar potency both 5-HT2CR with high specificity confirmed by site-directed...
The intermediate filament nestin is transiently expressed in neural stem/progenitor cells during the development of central nervous system. Recently, increasing evidence has shown that upregulation related to malignancy several cancers, especially glioblastoma. However, function carcinogenesis remains unclear. In this study, we investigated role glioblastoma by comparing subclones rat C6 were either high or low for expression. We found while expression did not influence vitro proliferation...
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high mortality, and there an urgent need new diagnosis measures. This study aimed at investigating whether circulating exosomal miRNAs could act as biomarkers for HCC. A four-stage strategy was adopted in this study. Candidate miRNA selected by comprehensive analysis four GEO datasets TCGA database. The expression candidate serum samples were examined through qRT-PCR. diagnostic utility final validated receiver...
Hepatitis E virus (HEV) is one of the main pathogenic agents acute hepatitis in world. The mechanism HEV replication, especially host factors governing replication still not clear. Here, using ORF1 trans-complementation cell culture system and replicon system, combining with stable isotope labelling amino acids (SILAC) mass spectrometry (MS), we aimed to identify regulating replication. We identified a diversity associated protein, which were putatively responsible for viral genomic RNA...
Ten new cadinane-type sesquiterpenoids, named hibisceusins I–R (1–10), along with 14 known sesquiterpenoids (11–24), were acquired from the tainted stems of Hibiscus tiliaceus. Their structures identified via spectroscopic analysis, one-dimensional (1D) and two-dimensional (2D) NMR, computer-assisted structure elucidation techniques, including infrared (IR) mass spectrometry (MS) data. Additionally, subsequent DP4/DP4+ probability methods used to resolve 3′s relative configurations by...
Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) unsatisfactory cellular permeability, instability, both vitro vivo have limited further clinical applications indole cyanine photosensitizers. Here, we explore supramolecular self-assembly a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, constructed hyalurosome...
Abstract Background Several studies have demonstrated autophagy was involved in the process of esophageal adenocarcinoma (EAC). The aim this study to explore autophagy-related genes (ARGs) correlated with overall survival (OS) EAC patients. Methods Expressions ARGs and normal samples were downloaded from TCGA database. GO KEGG enrichment analyses used investigate bioinformatics functions. Univariate multivariate cox regressions performed identify prognostic independent risk factors. ROC...
The expression of intermediate filament Nestin is necessary for the neural progenitor cells (NPCs) to maintain stemness, but underlying cellular and molecular mechanism remains unclear. In this study, we demonstrated that required self-renew NPCs through activating MAPK EGFR pathways. Knockdown by shRNA inhibited cell cycle progression proliferation in mouse NPCs. Moreover, suppression reduced epidermal growth factor receptor (EGFR) mitogenic effects EGF on these cells. Treatment with...
The purpose of this study was to evaluate the diagnostic performance multiparametric ultrasound (mpUS; grayscale US, color Doppler strain elastography, and contrast-enhanced US) in assessment testicular lesions with negative tumoral markers. MpUS imaging data, patient age, serum tumor markers, scrotal pain, cryptorchidism, related clinical information were retrospectively collected for patients who underwent mpUS examination between January 2013 December 2019. Histologic results or follow-up...