A5015905695- Neurobiology and Insect Physiology Research
- Cellular transport and secretion
- Genetics and Neurodevelopmental Disorders
- Animal Behavior and Reproduction
- Genomics and Rare Diseases
- Ubiquitin and proteasome pathways
- Lysosomal Storage Disorders Research
- Physiological and biochemical adaptations
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Congenital heart defects research
- Cerebrovascular and genetic disorders
- Circadian rhythm and melatonin
- Curcumin's Biomedical Applications
- Autophagy in Disease and Therapy
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Sphingolipid Metabolism and Signaling
- Ion Transport and Channel Regulation
- Cancer, Hypoxia, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Immunodeficiency and Autoimmune Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Metalloenzymes and iron-sulfur proteins
Baylor College of Medicine
2020-2025
Neurological Research Institute
2022-2024
Texas Children's Hospital
2022-2024
Army Medical University
2023
University of Minnesota
2016-2021
Peking University
2009-2016
Twin Cities Orthopedics
2016
Food and Drug Administration
2012
State Key Laboratory of Natural and Biomimetic Drugs
2012
Our study first proposed that curcumin could protect human endothelial cells from the damage caused by oxidative stress via autophagy. Furthermore, our results revealed causes some novel cellular mechanisms promote autophagy as a protective effect. Pretreatment with remarkably improves survival of umbilical vein (HUVECs) H 2O 2-induced viability loss, which specifically evokes an autophagic response. Exposed to 2, curcumin-treated HUVECs upregulate level microtubule-associated protein 1...
Adult size and fitness are controlled by a combination of genetics environmental cues. In Drosophila, growth is confined to the larval phase final body impacted duration this phase, which under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed play central role in controlling length through regulation ecdysone production, steroid that initiates molting metamorphosis. Here, we test examining consequences null mutations Ptth gene for Drosophila...
Abstract Sphingolipids are a diverse family of lipids with critical structural and signalling functions in the mammalian nervous system, where they abundant myelin membranes. Serine palmitoyltransferase, enzyme that catalyses rate-limiting reaction sphingolipid synthesis, is composed multiple subunits including an activating subunit, SPTSSA. both essential cytotoxic their synthesis must therefore be tightly regulated. Key to homeostatic regulation ORMDL proteins bound serine...
In holometabolous insects, metamorphic timing and body size are controlled by a neuroendocrine axis composed of the ecdysone-producing prothoracic gland (PG) its presynaptic neurons (PGNs) producing PTTH. Although PTTH/Torso signaling is considered primary mediator timing, recent studies indicate that other unidentified PGN-derived factors also affect timing. Here, we demonstrate receptor tyrosine kinases anaplastic lymphoma kinase (Alk) PDGF VEGF receptor-related (Pvr), function in...
Background Diuretic agents are widely used on the treatment of water retention related diseases, among which acetazolamide (AZA) acts originally as a carbonic anhydrase (CA) inhibitor. Aquaporin-1 (AQP1) being located in renal proximal tubules is required for urine concentration. Previously our lab has reported AZA putatively modulated AQP1. Aim this study to testify hypothesis that regulating AQP1 may mediate diuretic effect AZA. Methodology/Principal Findings For vivo study, we utilized...
Developmental transitions are often triggered by a neuroendocrine axis and can be contingent upon multiple organs achieving sufficient growth maturation. How the neurodendocrine senses size maturity of peripheral is not known. In Drosophila larvae, metamorphosis sharp increase in level steroid hormone ecdysone, secreted prothoracic gland (PG). Here, we show that BMP2/4 ortholog Dpp function as systemic signal to regulate developmental timing. from tissues, mostly imaginal discs, reach PG...
Correct scaling of body and organ size is crucial for proper development, the survival all organisms. Perturbations in circulating hormones, including insulins steroids, are largely responsible changing response to both genetic environmental factors. Such perturbations typically produce adults whose organs appendages scale proportionately with final size. The identity additional factors that might contribute unknown. Here, we report loss-of-function mutations
Tumor metastasis is a major cause leading to the deaths of cancer patients. Nordihydroguaiaretic acid (NDGA) natural product that has been demonstrated show therapeutic values in multiple diseases. In this study, we report NDGA can inhibit cell migration and tumor via novel mechanism. suppresses NRP1 function by downregulating its expression, which leads attenuated motility, adhesion ECM FAK signaling cells. Moreover, due cross-cell type activity on suppression, also impairs angiogenesis...
Dynamin-Related-Protein 1 (DRP1) critically regulates mitochondrial and peroxisomal fission in multicellular organisms. However, the impact of DRP1 on other organelles, especially its direct influence ER functions remains largely unclear. Here, we report that translocates to endoplasmic reticulum (ER) response β-adrenergic stimulation. To further investigate function ER-lipid droplet (LD) dynamics metabolic subsequences, generated an adipose tissue-specific knockout model (Adipo-Drp1flx/flx...
Background/Aims: Aquaporin-1 (AQP1) is a glycoprotein that mediates osmotic water transport, its expression has been found to correlate with tumour stage in some tumours. However, the mechanism by which AQP1 protein regulated tumor cells remains be fully elucidated. We hypothesized hypoxia might play an important role induction during tumorigenesis and at late stages of development. Methods: Isotonic serum-free hypoxic models were used investigate PC-3M human prostate cancer cells. Results:...
This collaborative study, led by the Clinical Genome Resource Severe Combined Immunodeficiency Disease Variant Curation Expert Panel (ClinGen SCID-VCEP), implemented and adapted American College of Medical Genetics Genomics/Association for Molecular Pathology (ACMG/AMP) guidelines interpreting germline variants in genes with established relationships to SCID. The effort focused on 7 most common SCID-related identified SCID newborn screening North America: ADA , DCLRE1C IL2RG IL7R JAK3 RAG1...
SUPT16H encodes the large subunit of FAcilitate Chromatin Transcription (FACT) complex, which functions as a nucleosome organizer during transcription. We identified two individuals from unrelated families carrying de novo missense variants in SUPT16H. The probands exhibit global developmental delay, intellectual disability, epilepsy, facial dysmorphism and brain structural abnormalities. used Drosophila to characterize variants: p.T171I p.G808R. Loss fly ortholog, dre4, causes lethality at...
Osteoarthritis (OA) is a non‑inflammatory degenerative joint disease, characterized by pain and stiffness. The prevalence of OA increases with age. However, the relationship between biomarkers [collagen type III α1 (COL3A1), COL5A1, COL6A2, COL12A1] remains unclear. subchondral bone dataset GSE51588 was downloaded from GEO database, differentially expressed genes (DEGs) were screened. Weighted gene co‑expression network analysis performed, protein‑protein interaction constructed further...