A5039390366- RNA modifications and cancer
- RNA Research and Splicing
- Supercapacitor Materials and Fabrication
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Hormonal and reproductive studies
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Estrogen and related hormone effects
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Biosensors and Analytical Detection
- Catalytic Processes in Materials Science
- Electrocatalysts for Energy Conversion
- Conducting polymers and applications
- Electrochemical Analysis and Applications
- Cardiac Imaging and Diagnostics
- Heat shock proteins research
- Pancreatitis Pathology and Treatment
- Protein Structure and Dynamics
- RNA Interference and Gene Delivery
- Analytical Chemistry and Chromatography
- Histone Deacetylase Inhibitors Research
- Technology Adoption and User Behaviour
Xiamen University
2023-2025
Jinling Institute of Technology
2013-2024
Changshu Institute of Technology
2016-2024
Nanjing University of Aeronautics and Astronautics
2024
Henan Provincial People's Hospital
2013-2024
Zhuhai Institute of Advanced Technology
2022-2023
Institut National de la Recherche Scientifique
2019-2023
University of Science and Technology of China
2023
Fujian Provincial Cancer Hospital
2023
Fujian Medical University
2023
Hydrogen is considered a promising clean energy vector with the features of high capacity and zero-carbon emission. Water splitting an environment-friendly effective route for producing high-purity hydrogen, which contains two important half-cell reactions, namely, anodic oxygen evolution reaction (OER) cathodic hydrogen (HER). At heart water high-performance electrocatalysts that efficiently improve rate selectivity key chemical reactions. Recently, perovskite oxides have emerged as...
Recently, Pt-Y alloy has displayed an excellent electrocatalytic activity for oxygen reduction reaction (ORR), and is regarded as a promising cathode catalyst fuel cells. However, the bulk production of nanoscaled with outstanding catalytic performance remains great challenge. Here, we address challenge through simple dealloying method to synthesize nanoporous (NP-PtY) typical ligament size ~5 nm. By combining intrinsic superior special structure, NP-PtY bimetallic presents higher ORR...
The exosome functions in the degradation of diverse RNA species, yet how it is negatively regulated remains largely unknown. Here, we show that NRDE2 forms a 1:1 complex with MTR4, nuclear cofactor critical for recruitment, via conserved MTR4-interacting domain (MID). Unexpectedly, mainly localizes speckles, where inhibits MTR4 recruitment and degradation, thereby ensures efficient mRNA export. Structural biochemical data revealed interacts MTR4's key residues, locks closed conformation,...
The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides a promising alternative for testosterone replacement therapies, including hormonal male contraception. identification an orally bioavailable SARM with the ability to mimic central and peripheral androgenic anabolic effects would represent important step toward "male pill". We characterized in vitro vivo pharmacologic activity...
Depsipeptide FK228 [(<i>E</i>)-(1<i>S</i>,4<i>S</i>,10<i>S</i>,21<i>R</i>)-7[(<i>Z</i>)-ethylideno]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone], a novel histone deacetylase (HDAC) inhibitor, previously was reported to be P-glycoprotein (Pgp) substrate. We now expand the investigation demonstrate that is substrate for Pgp and multidrug resistance-associated protein 1 (MRP1). Transport of across Caco-2 cell monolayer in apical...
The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer polypeptides that bind with high affinity specificity one of receptor coreceptor pairs used by FGF21, FGFR1c β-Klotho. These Avimers exhibit FGF21-like activity in vitro assays potency greater than FGF21. In study conducted obese male cynomolgus monkeys, animals treated FGFR1c/β-Klotho showed...
The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in subpopulation of sensory neurons that can be activated by wide range stimuli, including menthol, icilin, and cold temperatures (<25 °C). Antagonism TRPM8 currently under investigation as new approach for the treatment pain. As result our screening efforts, we identified tetrahydrothienopyridine 4 an inhibitor icilin-induced calcium influx CHO cells expressing recombinant rat...
We examined the three-dimensional quantitative structure−activity relationship (QSAR) of a group endogenous and synthetic compounds for androgen receptor (AR) using comparative molecular field analysis (CoMFA). The goal these studies was to identify structural features necessary high binding affinity optimization selective modulators (SARMs). A homology model AR used as scaffold align six lead that served templates alignment remaining 116 structures prior CoMFA modeling. conventional r2...
Histone acetylation status, an epigenetic determinant of gene transcription, is controlled by histone acetyltransferases (HATs) and deacetylases (HDACs). The potent HDAC inhibitor FK228 [(<i>E</i>)-(1<i>S</i>,4<i>S</i>,10<i>S</i>,21<i>R</i>)-7-[(<i>Z</i>)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] a substrate for multidrug resistance protein (MDR1) resistance-associated 1 (MRP1), both which mediate resistance. To...
A method of fluorescent nanoparticle-based indirect immunofluorescence microscopy (FNP-IIFM) was developed for the rapid detection Mycobacterium tuberculosis. An anti-Mycobacterium tuberculosis antibody used as primary to recognize tuberculosis, and then an binding protein (Protein A) labeled with Tris(2,2-bipyridyl)dichlororuthenium(II) hexahydrate (RuBpy)-doped silica nanoparticles generate signal microscopic examination. Prior detection, Protein immobilized on RuBpy-doped a coverage...
The pharmacologic effects of (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide (S-23) were characterized in male rats as an animal model hormonal contraception. S-23 showed high binding affinity (inhibitory constant = 1.7 +/- 0.2 nm) and was identified a full agonist vitro. In castrated rats, the ED50 prostate levator ani muscle 0.43 0.079 mg/d, respectively. intact treated for 14 d, alone suppressed LH levels by greater than 50% at doses...
In this work, we reported a simple method to fabricate nanoporous PdCe (NP-PdCe) nanocubes with high activity and good stability by melt spinning combined chemical dealloying.
Ultrasmall CoSe2 nanoparticles encapsulated by an N-doped carbon matrix were prepared selenizing a novel Co-metal organic framework precursor. The excellent electrochemical performance may be due to the synergistic effect of and ultrasmall CoSe2.
Abstract N-terminal acetylation (Nt-acetylation), carried out by acetyltransferases (NATs), is a conserved and primary modification of nascent peptide chains. Naa60 (also named NatF) recently identified NAT found only in multicellular eukaryotes. This protein was shown to locate on the Golgi apparatus mainly catalyze Nt-acetylation transmembrane proteins, it also harbors lysine N ε -acetyltransferase (KAT) activity ε-amine. Here, we report crystal structures human (hNaa60) complex with...