A5100346024- HIV Research and Treatment
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Influenza Virus Research Studies
- Viral Infections and Vectors
- RNA Research and Splicing
- Immune Cell Function and Interaction
- RNA modifications and cancer
- RNA regulation and disease
- Vector-Borne Animal Diseases
- Liver Disease Diagnosis and Treatment
- Vector-borne infectious diseases
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Cancer Research and Treatments
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
Harbin Veterinary Research Institute
2016-2025
Chinese Academy of Agricultural Sciences
2016-2025
Ningxia Medical University
2025
Gansu Provincial Hospital
2016-2025
Foshan University
2025
Shenyang Pharmaceutical University
2022-2025
Shanxi Academy of Medical Sciences
2023-2025
Shanxi Medical University
2023-2025
Ministry of Agriculture and Rural Affairs
2025
Guangxi Science and Technology Department
2025
Aux/IAA genes are early auxin response that encode short-lived nuclear proteins with four conserved domains, referred to as I, II, III, and IV. Arabidopsis repressed transcription on auxin-responsive reporter in protoplast transfection assays. Mutations domain II resulted increased repression, whereas mutations domains I III partially relieved repression. fused a heterologous DNA binding were targeted promoters of constitutively expressed actively an dose-dependent manner. In comparison...
Metabolic associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic disorders, including steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis. We demonstrated that phosphoenolpyruvate carboxykinase 1 (PCK1) plays central role in MAFLD progression. Male mice with Pck1 deficiency fed normal diet displayed lipid disorder injury, whereas fibrosis inflammation were aggravated high-fat drinking water containing fructose glucose (HFCD-HF/G). Forced expression PCK1 by...
A tandem arrayed gene cluster encoding seven cytidine deaminase genes is present on human chromosome 22. These are APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3DE, APOBEC3F, APOBEC3G, and APOBEC3H. Three of them, block replication immunodeficiency virus type 1 (HIV-1) many other retroviruses. In addition, APOBEC3A APOBEC3C intracellular retrotransposons simian (SIV), respectively. opposition to APOBEC genes, HIV-1 SIV contain a virion infectivity factor (Vif) that targets APOBEC3F APOBEC3G for...
A mutant screen was conducted in Arabidopsis that based on deregulated expression of auxin-responsive transgenes. Two different tightly regulated (i.e., very low the absence auxin treatment and high after exogenous treatment) promoters were used to drive both a β-glucuronidase (GUS) reporter gene hygromycin phosphotransferase (HPH)–selectable marker gene. This yielded several mutants, five mutations (axe1-1 axe1-5) mapped same locus chromosome 5. map-based cloning approach locate axe1 an...
Accumulated evidence has shown that long non-coding RNAs (lncRNA) act as a widespread layer in gene regulatory networks and are involved wide range of biological processes.
DNA flap endonuclease 1 (FEN1) plays critical roles in maintaining genome stability and integrity by participating both replication repair. Suppression of FEN1 cells leads to the retardation accumulation unrepaired intermediates, resulting double strand breaks (DSBs) apoptosis. Therefore, targeting could serve as a potent strategy for cancer therapy. In this study, we demonstrated that is overexpressed breast cancers essential rapid proliferation cells. We showed manipulating levels alters...
Abstract Rapid profiling of stress-response at single-cell resolution yet in a label-free, non-disruptive and mechanism-specific manner can lead to many new applications. We propose single-cell-level biochemical fingerprinting approach named “ramanome”, which is the collection Single-cell Raman Spectra (SCRS) from number cells randomly selected an isogenic population given time condition, rapidly quantitatively detect characterize stress responses cellular population. SCRS Escherichia coli...
Abstract Colorectal cancer (CRC) is a very common metastatic tumor with active angiogenesis that requires angiogenesis. Recently, increased microRNA-181a-5p (miR-181a) expression was found to be significantly associated liver metastasis and poor outcome in CRC patients. In this study, the role of miR-181a further investigated. Capillary tube formation assays were used demonstrate ability promote Bioinformatics analyses identified SRC kinase signaling inhibitor 1 (SRCIN1) as potential target...
KRAS is one of the most frequently activated oncogenes in human cancers. Although role mutation tumorigenesis and tumor maintenance has been extensively studied, relationship between immune microenvironment not fully understood. Here, we identified a driving evasion from innate surveillance. In samples lung adenocarcinoma patients Kras-driven genetic mouse models cancer, mutant expression cluster differentiation 47 (CD47), an antiphagocytic signal cancer cells, leading to decreased...
Species-specific differences in acidic nuclear phosphoprotein 32 family member A (ANP32A) determine the restriction of avian-signature polymerase mammalian cells. Mutations that evade this restriction, such as PB2-E627K, are frequently acquired when avian influenza viruses jump from hosts to hosts. However, mechanism underlying adaptation process is still unclear. Here, we report host factor ANP32 proteins can be incorporated into viral particles through combination with RNA (vPol) and then...
Epigenetics refers to heritable changes in gene expression and function that impact nuclear processes associated with chromatin, all without altering DNA sequences. These epigenetic patterns, being traits, are vital biological mechanisms intricately regulate heredity. The application of chemical labeling single-cell resolution mapping strategies has significantly facilitated large-scale modifications nucleic acids over recent years. Notably, can induce phenotypic changes, cell...
The human genome encodes seven APOBEC3 (A3) cytidine deaminases with potential antiretroviral activity: A3A, A3B, A3C, A3DE, A3F, A3G, and A3H. A3G was the first identified to block replication of immunodeficiency virus type 1 (HIV-1) many other retroviruses. A3DE were shown later have similar activities. HIV-1 produces a protein called Vif that is able neutralize activities but not A3B. Only activity A3H remains be defined due its poor expression in cell culture. Here, we studied mechanism...
Moloney leukemia virus 10 (MOV10) protein is a superfamily-1 RNA helicase, and it also component of the RNA-induced silencing complex. Recent studies have shown that MOV10 plays an active role in interference pathway. Here, we report inhibits retrovirus replication. When was overexpressed viral producer cells, able to reduce infectivity human immunodeficiency type 1 (HIV-1), simian virus, murine virus. Conversely, when expression reduced by small interfering RNAs, HIV-1 increased....
ABSTRACT Human APOBEC3H (A3H) has one cytidine deaminase domain (CDD) and inhibits the replication of retrotransposons human immunodeficiency virus type 1 (HIV-1) in a Vif-resistant manner. A3H five single amino acid polymorphisms (N15Δ, R18L, G105R, K121D, E178D), four haplotypes (I to IV) have previously been identified various populations. Haplotype II was primarily found African-derived populations, it only that could be stably expressed. Here, we three new from six population samples,...
The key host factors involved in the influenza A viral polymerase activity and RNA replication remain largely unknown. We provide evidence here that ANP32A ANP32B from different species are powerful maintenance of activity. Human contribute equally to support human replication. However, unlike avian ANP32A, is evolutionarily nonfunctional supporting because a mutation at sites 129 130. These play an important role ANP32A/ANP32B interaction therefore determine replication, suggesting novel...
Abstract Water scarcity is one of the most prominent issues worldwide in relation to sustainable development, especially arid areas. To gain a better understanding trade‐off between improving agricultural productivity and maintaining stability an oasis ecosystem these areas, this study took Heihe River Basin northwestern China as case explore changes dynamics their human driving forces. The results showed that along with 11·0% expansion land, total water demand for irrigation increased by...
Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. The aims this study were to provide an estimate prevalence PCOS clinical practice; compare risk established cardiovascular factors, disease, and other comorbid conditions with that age- race-matched controls; explore total costs care can be attributed PCOS. Methods Louisiana Medicaid claims data used identify or its defining features a control group ratio 1:3. PCOS, factors...