A5101949479- Influenza Virus Research Studies
- Rabies epidemiology and control
- Mosquito-borne diseases and control
- interferon and immune responses
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- Viral Infections and Vectors
- Neuropeptides and Animal Physiology
- Chemokine receptors and signaling
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Microbial Natural Products and Biosynthesis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Stress, Anesthesia, and Immune Response
- RNA and protein synthesis mechanisms
- Respiratory viral infections research
- Genomics and Phylogenetic Studies
- Nanoplatforms for cancer theranostics
- Herpesvirus Infections and Treatments
- Catalysts for Methane Reforming
- Medical Research and Treatments
- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
Shanghai Jiao Tong University
2025
Sichuan University
2006-2024
Jilin University
2022-2024
Heze University
2024
Shenzhen Bay Laboratory
2023-2024
Sichuan Agricultural University
2024
Chinese Academy of Agricultural Sciences
2019-2023
Harbin Veterinary Research Institute
2019-2023
Ministry of Education of the People's Republic of China
2023
Wenzhou University
2023
Species-specific differences in acidic nuclear phosphoprotein 32 family member A (ANP32A) determine the restriction of avian-signature polymerase mammalian cells. Mutations that evade this restriction, such as PB2-E627K, are frequently acquired when avian influenza viruses jump from hosts to hosts. However, mechanism underlying adaptation process is still unclear. Here, we report host factor ANP32 proteins can be incorporated into viral particles through combination with RNA (vPol) and then...
The key host factors involved in the influenza A viral polymerase activity and RNA replication remain largely unknown. We provide evidence here that ANP32A ANP32B from different species are powerful maintenance of activity. Human contribute equally to support human replication. However, unlike avian ANP32A, is evolutionarily nonfunctional supporting because a mutation at sites 129 130. These play an important role ANP32A/ANP32B interaction therefore determine replication, suggesting novel...
Abstract Antimicrobial resistance remains a significant global threat, driving up mortality rates worldwide. Ribosomally synthesized and post-translationally modified peptides have emerged as promising source of novel peptide antibiotics due to their diverse chemical structures. Here, we report the discovery new aminovinyl-(methyl)cysteine (Avi(Me)Cys)-containing through synergistic approach combining biosynthetic rule-based omics mining heterologous expression. We first bioinformatically...
Both the replication and transcription of influenza virus are catalyzed by viral polymerase complex. The polymerases most avian A viruses have poor performance in mammalian cells, which is considered to be one important species barriers. Pigs been long as intermediate hosts for interspecies transmission virus, because their susceptibility infection with both viruses. However, molecular basis adaptation pigs remains largely unknown. ANP32A ANP32B proteins identified playing fundamental roles...
Sunitinib, a receptor tyrosine kinase (RTK) inhibitor that targets multiple receptors such as vascular endothelial growth factor (VEGFRs), was approved for cancer treatment in 2006. However, it unsuccessful treating certain cancers, particularly metastatic breast (MBC), and the mechanism underlying this "sunitinib resistance" remains unclear. Herein, we investigated whether sunitinib-associated inferior survival benefit MBC due to sunitinib-induced cell (EC) injury or EC senescence. 4T1...
Species differences in the host factor ANP32A/B result restriction of avian influenza virus polymerase (vPol) mammalian cells. Efficient replication viruses cells often requires adaptive mutations, such as PB2-E627K, to enable use ANP32A/B. However, molecular basis for productive without prior adaptation mammals remains poorly understood. We show that NS2 protein help overcome ANP32A/B-mediated vPol activity by promoting vRNP assembly and enhancing ANP32A/B-vRNP interactions. A conserved...
Abstract Rabies is a zoonotic neurological disease caused by the rabies virus (RABV) that fatal to humans and animals. While several post‐infection treatment have been suggested, developing more efficient innovative antiviral methods are necessary due limitations of current therapeutic approaches. To address this challenge, strategy combining photodynamic therapy immunotherapy, using photosensitizer (TPA‐Py‐PhMe) with high type I II reactive oxygen species (ROS) generation ability proposed....
A key step during the biosynthesis of cytochalasans is a proposed Knoevenagel condensation to form pyrrolone core, enabling subsequent 4+2 cycloaddition reaction that results in characteristic octahydroisoindolone motif all cytochalasans. In this work, we investigate role highly conserved α,β-hydrolase enzymes PyiE and ORFZ pyrichalasin H ACE1 metabolite, respectively, using gene knockout complementation techniques. Using synthetic aldehyde models demonstrate proceeds spontaneously but...
<title>Abstract</title> Background The physical and mental health of nurses is closely related to the quality nursing patient safety. Nurses face greater risks, which are procrastination. At present, China lacks scientifically effective tools assess level health-related procrastination among clinical nurses. purpose this study was conduct cross-cultural debugging Nurses’ Health-Related Procrastination Scale (NHRPS) test reliability validity Chinese version NHRPS Methods translated strictly...
The influenza B virus (IBV) causes seasonal and has accounted for an increasing proportion of outbreaks. IBV mainly human infections not been found to spread in poultry. replication mechanism the determinants interspecies transmission are largely unknown. In this study, we that host ANP32 proteins required function polymerase. Human ANP32A/B strongly supports replication, while ANP32E a limited role. Unlike ANP32A/B, chicken ANP32A low support activity polymerase because unique 33-amino-acid...
The emergence of Zika virus (ZIKV) infection, which is unexpectedly associated with congenital defects, has prompted the development safe and effective vaccines. Gram-positive enhancer matrix-protein anchor (GEM-PA) display system emerged as a versatile highly platform for delivering target proteins in In this study, we developed bacterium-like particle vaccine, ZI-△-PA-GEM, based on GEM-PA system. fusion protein ZI-△-PA, contains prM-E-△TM ZIKV (with stem-transmembrane region deletion) PA3,...
Abstract Tick‐borne encephalitis (TBE) is a natural focal disease with fatal induced by tick‐borne virus (TBEV), seriously threatening human and public health. Protection of TBE depends on vaccination inactivated vaccine, which requires high cost multiple immunizations. Here, we construct genetically engineered bacterial‐like particles (BLPs) as an effective TBEV vaccine simplified immunizations improved immune efficacy. The BLPs involve the combination gram‐positive enhancer matrix from...
Equine influenza virus (EIV) causes severe acute respiratory disease in horses. Currently, the strains belonging to H3N8 subtype are divided into two clades, Florida clade 1 (FC1) and 2 (FC2), which emerged 2002. Both FC1 FC2 clades were reported Asian Middle East countries last decade. In this study, we described evolution, epidemiology, molecular characteristic of EIV lineages, with focus on those detected Asia from 2007 2017. The full genome phylogeny showed that constituted separate...