A5100384451- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Nanoplatforms for cancer theranostics
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Photodynamic Therapy Research Studies
- Infection Control and Ventilation
- COVID-19 and Mental Health
- Respiratory Support and Mechanisms
- Gastrointestinal disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Chronic Kidney Disease and Diabetes
- Single-cell and spatial transcriptomics
- Aortic Disease and Treatment Approaches
- RNA regulation and disease
- Teratomas and Epidermoid Cysts
- Head and Neck Anomalies
- Respiratory viral infections research
- Metastasis and carcinoma case studies
Stanford University
2025
Hangzhou Medical College
2023-2025
Zhongda Hospital Southeast University
2020-2024
Nanchang University
2020-2024
National Clinical Research Center for Digestive Diseases
2023
Central South University
2023
Lanzhou University
2022-2023
Lanzhou University Second Hospital
2022-2023
Xiangya Hospital Central South University
2023
Zhongnan Hospital of Wuhan University
2022
Spatial omics is enabling unprecedented tissue characterization, but the ability to adequately compare spatial features across samples under different conditions lacking. We propose a quantitative framework that catalogs significant, normalized, colocalizations between pairs of cell subpopulations, comparisons among variety biological samples. perform cell-pair colocalization analysis on multiplexed immunofluorescence images assembloids constructed with lung adenocarcinoma (LUAD) organoids...
Abstract Limited endoscopic sphincterotomy (EST) combined with papillary balloon dilation (EPBD) is widely used. However, the optimal duration of small in choledocholithiasis remains controversial. We aimed to determine for 10 mm diameter after limited EST choledocholithiasis. In this randomized controlled clinical trial, 320 patients were randomly assigned receive (10 diameter) 1 min (n = 160) or 3 deep bile duct cannulation. No significant difference success rate stone extraction between...
Crystal-cell interactions are a vital step toward kidney stone formation. However, its mechanisms remained unclear. Here, protein-protein interaction (PPI) network analysis of revealed that the proteins were enriched in posttranslational protein modification process endoplasmic reticulum (ER). The vitro study showed markers ER stress, including Bip and CHOP, upregulated, PERK ATF6 activated, XBP-1 mRNA was spliced. An stress-specific protein, caspase-12, activated apoptotic cells induced by...
Type I interferon and apoptosis elicit multifaceted effects on host defense various diseases, such as viral infections cancers. However, the gene/protein network regulating type has not been elucidated completely. In this study, we selected grass carp ( Ctenopharyngodon idella ) an experimental model to investigate modulation of RNASEK secretion apoptosis. We first cloned two paralogs RNASEK-a -b in carp, defined three exons each gene, found length both coding regions is 306 bp with 73.27%...
Endoscopic retrograde cholangiopancreatography (ERCP) has become an important method to diagnose and treat biliary-pancreatic diseases. Perforations are infrequent but serious complications can occur during ERCPs. However, it is unclear which patients suitable for surgery when these should receive surgery.To analyze the outcome of 45 with endoscopic related perforation.We retrospectively reviewed all ERCP-related perforation between January 2003 December 2017, observed location causes...
The use of nonradiation endoscopic retrograde cholangiopancreatography (NR-ERCP) for choledocholithiasis is still limited. Hereby, we introduced our experience digital cholangioscopy (DCS)-assisted NR-ERCP retrieval common bile duct stones.Altogether, data 132 patients who underwent DCS-assisted were collected. Procedure details, complications, and short-term follow-up reviewed analyzed compared with those conventional (ERCP).Routine stone extraction laser lithotripsy planned in 116 16...
Background. Continuous nursing based on 5E rehabilitation mode can improve the physiology and psychology of patients to some extent. The purpose this study was explore effect continuous prevention prognosis severe respiratory tract infection in with tracheotomy neurosurgery. Objective. To model Methods. starting ending time is from February 2019 July 2021. In paper, 60 were divided into control group research according random number table method. former received routine nursing, latter 5E....
Radiation-free one-stage bedside endoscopic stone removal and biliary drainage for severe acute cholangitis (SAC) caused by choledocholithiasis in intensive care unit (ICU) has not been reported. Herein, we introduce our preliminary experience of such intervention. digital cholangioscope-assisted was performed an urgent manner. Data on clinical outcomes follow-up from thirty patients were retrospectively analyzed. Time interval 7.6 ± 4.7 (2–18) h between ICU admission intervention, 35.5 14.5...
Endoscopic submucosal dissection (ESD) is a technically difficult endoscopic procedure for treating gastrointestinal diseases. Procedure time longer, and complications such as mucosal defects, intraoperative perforation, bleeding occur frequently. Here, to solve these problems, we described the clip-with-line traction suture method that applied performed closing defects after ESD in three representative cases.
Objective To improve the knowledge of tracheobronchomegaly (TBM, Mounier-Kuhn syndrome). Methods One patient with TBM was analyzed, and related literatures were reviewed. Results ①TBM an extremely rare disease, although etiology unknown, most scholars believed that a congenital disorder.②TBM characterized by defect or atrophy elastic smooth muscle tissue trachea main bronchi. Pulmonary function tests showed obstructive ventilatory dysfunction.③The onset slowly, its usual...
Ethnopharmacological revelvance: Pulmonary fibrosis (PF) is an irreversible lung disease that severely affects human respiratory function. Traditionally, the natural plant Quzhou Fructus Arantii (QFA) has therapeutic effects on diseases. However, and mechanism of anti-pulmonary have not been elucidated.Aim study: In this study, QFAE-nB was extracted from QFA, objectives study include understanding correlation between Bleomycin (BLM)-induced PF STING pathway in mice, as well exploring role...
Objective To discuss the clinical characteristics, pathological features, and reasons for under-diagnosis of 54 intrapulmonary teratoma (IPT) patients. Methods It was searched that 52 IPT patients in PubMed, WANFANG DATA Chinese National infrastructure(CNKI) from 2000 to 2016 combing with 2 cases diagnosed Xiangya Hospital Central South University analyze characteristics reason under-diagnosis. Results The majority occured young male adults without smoking which located at left...
Abstract Background Few studies have evaluated digital cholangioscopy (DCS) assisted non-radiation endoscopic retrograde cholangiopancreatography (NR-ERCP) for choledocholithiasis. Here, we the application of DCS NR-ERCP retrieval common bile duct (CBD) stones. Methods Patients who underwent ERCP choledocholithiasis and without prior were included. Data related to technical success outcomes DCS-assisted conventional retrieved compared. Procedure details collated reviewed. Results In total,...
A 65-year-old male was admitted to our department with chief complaint of ‘hoarseness and choking cough for more than 2 months’, laryngoscopy showed that the left vocal cord paralyzed. Further aortic computed tomography angiography (CTA) revealed lateral arch aneurysms accompanied a rough ascending wall (Panels B). So primary diagnosis atherosclerosis aneurysm. We suspected compressed recurrent laryngeal nerve, resulting in hoarseness. However, later three-dimensional reconstruction CTA, it...
Abstract Background and Aim: To date, Optimal endoscopic management of severe acute cholangitis (SAC) caused by choledocholithiasis remains controversial. The aim our study was to assess the safety efficacy digital cholangioscope-assisted one-stage bedside stone removal combined with biliary drainage for patients SAC in intensive care unit (ICU). Methods: Patients admitted ICU were prospectively included. Initial treatment, including fluid resuscitation, antibiotics organ support,...