A5101409000- Plant and animal studies
- Insect and Pesticide Research
- Biological and pharmacological studies of plants
- Medicinal Plants and Bioactive Compounds
- Viral Infections and Vectors
- Immune Response and Inflammation
- Optimism, Hope, and Well-being
- Insect and Arachnid Ecology and Behavior
- Inflammasome and immune disorders
- Polysaccharides and Plant Cell Walls
- interferon and immune responses
- Chemotherapy-induced cardiotoxicity and mitigation
- Gut microbiota and health
- Graphene and Nanomaterials Applications
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Natural Compound Pharmacology Studies
- Wound Healing and Treatments
- Inhalation and Respiratory Drug Delivery
- Electron Spin Resonance Studies
- Chemotherapy-induced organ toxicity mitigation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Inflammation biomarkers and pathways
- Ocular Surface and Contact Lens
Hangzhou Medical College
2019-2025
Sun Yat-sen University
2021
Eighth Affiliated Hospital of Sun Yat-sen University
2021
Zhejiang Academy of Medical Sciences
2007-2019
N-acetyltransferase 10 (NAT10) is the key enzyme for N4-acetylcytidine (ac4C) modification of mRNA, which participates in various cellular processes and related to many diseases. Here, we explore relationships among osteoblast differentiation, NAT10, ac4C, found that NAT0 expression ac4C level total RNA were decreased bone tissues bilateral ovariectomized (OVX) mice osteoporosis patients. Adenoviruses overexpressing NAT10 reversed loss, Remodelin, an inhibitor, enhanced loss mass OVX mice....
The broad-spectrum antineoplastic drug doxorubicin (DOX) has one of the most serious chronic side effects on heart, dilated cardiomyopathy, but precise molecular mechanisms underlying disease progression subsequent to long latency periods remain puzzling. Here, we established a model DOX-induced cardiomyopathy. In cardiac cytology exploration, found that differentially expressed genes in KEGG signaling pathway enrichment provided novel complex network mTOR bridging autophagy and oxidative...
Abstract The objective of this work was to explore the hypothesis that Lycium barbarum (LB) may be protective against doxorubicin (DOX)‐induced cardiotoxicity through antioxidant‐mediated mechanisms. Male SD rats were treated with distilled water or a extract LB (25 mg/kg, p.o.) daily and saline DOX (5 i.v.) weekly for 3 weeks. Mortality, general condition body weight observed during experiment. DOX‐induced assessed by electrocardiograph, heart antioxidant activity, serum levels creatine...
Acute respiratory distress syndrome (ARDS) is an acute disease characterized by bilateral chest radiolucency and severe hypoxemia. Quzhou Fructus Aurantii ethyl acetate extract (QFAEE), which prepared from the traditional Chinese anti-inflammatory natural herb Arantii, has potential to alleviate ARDS. In this work, we aimed investigate mechanism underlying action of QFAEE on ARDS how modulates STING pathway reduce type I interferon release inflammatory response. Lipopolysaccharide (LPS), a...
Dendrobium polysaccharide exhibits multiple biological activities, such as immune regulation, antioxidation, and antitumor. However, its resistance to viral infection by stimulating immunity is rarely reported. In this study, we explored the effect mechanism of DVP-1, a novel from devonianum, in activation immunity. After being activated ability mice prevent H1N1 influenza virus was investigated. Results regulation showed that DVP-1 significantly improved organ index, lymphocyte...
Salidroside (SDS) has been reported to have anti-inflammatory properties. The objective of this study was investigate the protective effect SDS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. BALB/c mice were pretreated with 1 hour before intranasal instillation LPS. Seven hours after LPS administration, myeloperoxidase histology lungs, wet/dry ratio, and inflammatory cells bronchoalveolar lavage fluid (BALF) determined. levels pro-inflammatory cytokines, tumor necrosis...
The gut microbiota affects the health and overall fitness of bumblebees. It can enhance host's ecological range by leveraging their metabolic capacities. However, diversity adaptive functional evolution in high-altitude regions remain unclear. To explore how helps host adapt to environments, we analyzed differences function between high- low-altitude through full-length 16S rRNA sequencing. Our results show that have a lower abundance Fructobacillus Saccharibacter compared regions....
Aurantiamide acetate (AA) is a dipeptide derivative with complex pharmacological activities and remarkable effects on preventing treating various diseases. In the current study, we aimed to investigate whether AA can exert protective in mouse model of ALI induced by LPS.In this model, mice were given intranasal LPS for 3 days prior receiving (2.5, 5, 10 mg/kg) via oral gavage. An assessment histopathological changes was performed hematoxylin eosin (HE). Proinflammatory cytokines detected...
Pulmonary fibrosis (PF) is an irreversible lung disease that severely affects human respiratory function. Traditionally, the natural plant Quzhou Fructus Arantii (QFA) has therapeutic effects on diseases. However, and mechanism of anti-fibrotic have not been elucidated. In this study, QFAE-nB was extracted from QFA, aims study include understanding correlation between Bleomycin (BLM)-induced PF STING pathway in mice, as well exploring role mechanisms treatment PF. six main chemical...
Abstract Wild bumble bees (Hymenoptera: Apidae) play a vital role in agro-ecosystems as important pollinators. However, they are threatened by virus pathogens that widespread honey bees. Previous studies have reported viruses were able to be transmitted across bee genera and caused potential danger wild China is global biodiversity hotspot for the impact of on communities remains elusive. Black queen cell (BQCV) one most common viruses. Here, total 72 samples from 17 geographic regions...
Gut microbiota of the bumblebee is critical as it modulates health and fitness host. However, mechanisms underlying formation maintenance diversity gut bacteria over a long period evolution have yet to be elucidated. In particular, bacterial community assembly processes
Influenza A virus infections can cause acute lung injury (ALI) in humans; thus, the identification of potent antiviral agents is urgently required. Herein, effects salidroside on influenza virus-induced ALI were investigated a murine model. BALB/c mice intranasally inoculated with H1N1 and treated salidroside. The results this study show that treatment (30 60 mg/kg) significantly attenuated histological alterations inhibited inflammatory cytokine production. Salidroside also decreased...
Background and Objective: Dendrobium devonianum officinale are widely used as Chinese medicinal materials health foods.These two species have similar appearances chemical constitutions.However, their immunomodulating activities never been compared.This study aims to investigate compare the of D. officinale.Materials Methods: Ten batches were collected from different regions.The botanical origins authenticated by DNA sequence analysis total polysaccharide contents determined guarantee quality...
Ethnopharmacological revelvance: Pulmonary fibrosis (PF) is an irreversible lung disease that severely affects human respiratory function. Traditionally, the natural plant Quzhou Fructus Arantii (QFA) has therapeutic effects on diseases. However, and mechanism of anti-pulmonary have not been elucidated.Aim study: In this study, QFAE-nB was extracted from QFA, objectives study include understanding correlation between Bleomycin (BLM)-induced PF STING pathway in mice, as well exploring role...
The self-pollination ability of blueberries is weak, thus making pollinators essential in greenhouse blueberry production. Because different have diverse adaptations to plants, we conducted observation and counting foraging activity, single visit pollen deposition multiple by three (Bombus terrestris, Apis mellifera A. cerana) 'Bluesouth (M7)' plants grown greenhouses. study found that had a significantly longer duration (18.55 ± 0.44 s) than both cerana (12.66 0.17 B. terrestris (9.31 0.41...
Exploring herbs and their compounds for potential drugs is a significant research focus due to the incurable nature of Sjögren’s syndrome (SS), prevalent chronic inflammatory autoimmune disease. Dendrobium officinale polysaccharide (DOP) has demonstrated diverse biological effects, particularly in immunomodulation. Nonetheless, limited been conducted on DOP concerning treatment SS. This aims examine impacts experimental SS (ESS) mice its possible mechanisms. An ESS animal model was...