A5100394036- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- SARS-CoV-2 detection and testing
- Medical Imaging Techniques and Applications
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- PI3K/AKT/mTOR signaling in cancer
- DNA Repair Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
Huazhong University of Science and Technology
2016-2025
Fujian Medical University
2016-2025
Southern Medical University
2019-2025
First Affiliated Hospital of Fujian Medical University
2016-2025
Capital Institute of Pediatrics
2025
Union Hospital
2015-2024
Tongji Hospital
2017-2024
Wuhan Union Hospital
2013-2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Abstract Objective To study the clinical characteristics of patients in Zhejiang province, China, infected with 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for disease (covid-2019). Design Retrospective case series. Setting Seven hospitals China. Participants 62 admitted to hospital laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 26 2020. Main outcome measures Clinical data, using a standardised report form, such as...
The aim of this paper was to monitor the presence SARS-Cov-2 among hospital environment surfaces, sewage, and personal protective equipment (PPE) staffs in isolation wards First Affiliated Hospital Zhejiang University, China.Surfaces objects were routinely wiped with 1000mg/L chlorine containing disinfectant. Air sewage disinfection proceeded strictly. environmental surfaces PPE sampled using swabs. from various inlet outlets sampled. respiratory stool specimens patients collected. also once...
A novel coronavirus (COVID-19) pandemic threatens the world. Here, we first studied dynamics profile of SARS-CoV-2 from 56 recovered patients with COVID-19. We found viral shedding occurred up to 6 weeks after onset symptoms. prolonged observation period is necessary for older patients.
With the spread of Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection, its effect on society is amplified. We aimed to describe viral detection results across different timepoints throughout disease course.A retrospective study 301 confirmed COVID-19 patients hospitalized at Tongji Hospital in Wuhan, China, were included. Demographic characteristics collected. Upper respiratory specimens (throat and/or nasal swabs) obtained...
Abstract Background Trop2 is a cell-surface glycoprotein overexpressed by variety of epithelial carcinomas with reported low to restricted expression in normal tissues. Expression has been associated increased tumor aggressiveness, metastasis and decreased patient survival, but the signaling mechanisms mediated are still unknown. Here, we studied effects murine (mTrop2) exerted on cellular functions some activated this oncogene. Results mTrop2 significantly cell proliferation at serum...
Background Although immune checkpoint blockade (ICB) has been proven to achieve a persistent therapeutic response in various tumor types, only 20%–40% of patients benefit from this treatment. Radiotherapy (RT) can enhance immunogenicity and improve the ICB response, but outcome achieved by combining these two modalities remains clinically unsatisfactory. We previously uncovered that lysine-specific demethylase 4C (KDM4C) is regulator radiosensitivity lung cancer. However, role KDM4C...
Abstract Background Radiation-induced lung injury (RILI) is the most common and serious complication of chest radiotherapy. However, reported radioprotective agents usually lead to radiation resistance in tumor cells. The key solving this problem distinguish between response cells normal epithelial damage. Methods RNA-Seq was used recognize potential target alleviating progression RILI as well inhibiting growth. activation NLRP3 inflammasome screened by qRT-PCR, western blotting,...
One of the hallmark findings in patients suffering from SARS (severe acute respiratory syndrome) is lymphopenia, which result massive lymphocyte death. SARS-CoV (SARS coronavirus), a novel coronavirus that has been etiologically associated with cases, homologous MHV (murine hepatitis and small envelope E protein capable inducing apoptosis. We hypothesized encodes protein, thus T-cell To test this hypothesis, cDNA encoding was created using whole gene synthesis. Our results showed induced...
Decreased platelet (PLT) count is one of the independent risk factors for mortality in intensive care unit (ICU) patients. This study was to investigate relationship between PLT indices and illness severity their performances predicting hospital mortality.Adult patients who admitted ICU Changzheng Hospital from January 2011 September 2012 met inclusion criteria were included this study. Univariate analysis used identify potential mortality. Multiple logistic regression calculate adjusted...
Background: This study aims to develop and validate an effective nomogram estimate the individual outcome of patients with Gastric neuroendocrine neoplasms (G-NENs).Methods: A total 260 diagnosed G-NENs at two medical centers were included, 156 allocated as training set 104 validation.Predictive was constructed based on multivariate analyses using RMS package in R version.The predictive accuracy discriminative ability analyzed by C-index, risk group stratification calibration curve, which...
Abstract We conducted a multicentre cross-sectional survey of COVID-19 patients to evaluate the acute psychological impact on with coronavirus disease 2019 (COVID-19) during isolation treatment based online questionnaires from 2 February 5 March 2020. A total 460 13 medical centers in Hubei province were investigated for their mental health status using (including Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Questionnaire-15, and Insomnia Severity Index scales). Among all...
// Rui Zhou 1, * , Xiaoshu Zhongyuan Yin 1 Jing Guo 2 Ting Hu Shun Jiang 3 Li Liu Xiaorong Dong Sheng Zhang Gang Wu Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department Oncology The Affiliated Hospital Qingdao University, Qingdao, Oncology, Second Xiangya Central South Changsha, These authors have contributed equally to this work Correspondence to: Wu, e-mail: xhzlwg@163.com Keywords: miR-184, miR-574-5p, metastasis,...
Abstract Background To explore the dosimetric improvement, delivery efficiency, and plan robustness for bilateral head neck cancer (HNC) treatment utilizing a novel proton therapy technique – spot-scanning arc (SPArc) therapy. Methods We evaluated fourteen HNC patients retrospectively. Both SPArc 3-field Intensity Modulated Proton Therapy (IMPT) plans were generated each patient using same robust optimization parameters. The prescription doses 70Gy (relative biological effectiveness (RBE)...
Pneumonia coronavirus disease 2019 (COVID-19) has became a pandemic. However, information on early risk factors for the duration of severe acute respiratory syndrome 2 (SARS-CoV-2) viral positivity is not yet available.In this prospective study, cohort 137 patients with confirmed SARS-CoV-2 were enrolled. Clinical and laboratory data retrieved from electronic medical records. Viral was calculated by interval day positive results to testing showed negative in these COVID-19. Early...
This study aimed to explore the prevalence of psychological disorders and associated factors at different stages COVID-19 epidemic in China.The mental health status respondents was assessed via Patient Health Questionnaire-9 (PHQ-9), Insomnia Severity Index (ISI) Generalized Anxiety Disorder 7 (GAD-7) scale.5657 individuals participated this study. History chronic disease a common risk factor for severe present depression (OR 2.2, 95% confidence interval [CI], 1.82-2.66, p < 0.001), anxiety...
Trop2 is a recently discovered cell surface glycoprotein overexpressed in pancreatic cancer which could potentially be used as an immunotherapeutic target. Enveloped virus-like particles (VLPs) are highly immunogenic and versatile immune stimulatory agents can modified to incorporate exogenous proteins on their membrane envelope use vaccines. In this study, we investigated the effects of murine (mTrop2) VLP immunization syngeneic model. VLPs incorporating mTrop2 were immunize C57BL/6...
CDP138, a CDK5 binding partner, regulates cell proliferation and migration. However, the mechanisms by which CDP138 functions in these processes remain unclear. In this study, we show that is frequently overexpressed high levels of are correlated with lymph node metastasis lung cancer. Furthermore, provide evidence CDP138-depleted cancer cells exhibit enhanced radiosensitivity as well reduced migration invasion. Mechanistically, identify GDF15, member TGF-β superfamily, key downstream...