A5021691628- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Moyamoya disease diagnosis and treatment
- interferon and immune responses
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Immune Response and Inflammation
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Mitochondrial Function and Pathology
- Hepatitis C virus research
- Viral Infections and Outbreaks Research
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Dermatologic Treatments and Research
- Traditional Chinese Medicine Analysis
- Acute Ischemic Stroke Management
- Viral gastroenteritis research and epidemiology
- COVID-19 diagnosis using AI
First Affiliated Hospital Zhejiang University
2015-2025
Zhejiang University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2019-2025
Sun Yat-sen University
2018-2025
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2015-2025
National Clinical Research Center for Digestive Diseases
2024-2025
Guangxi Medical University
2023
University Research Co (United States)
2021
ORCID
2021
Hangzhou First People's Hospital
2021
Abstract Objective To study the clinical characteristics of patients in Zhejiang province, China, infected with 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for disease (covid-2019). Design Retrospective case series. Setting Seven hospitals China. Participants 62 admitted to hospital laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 26 2020. Main outcome measures Clinical data, using a standardised report form, such as...
Objective The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province determine epidemiological, clinical virological characteristics. Design hospital patients were admitted from 17 January 2020 8 February 2020. Epidemiological, demographic, clinical, laboratory, management outcome data of using multivariate analysis for...
An outbreak of coronavirus disease 2019 (COVID-19) is becoming a public health emergency. Data are limited on the duration and host factors related to viral shedding.In this retrospective study, risk associated with severe acute respiratory syndrome 2 (SARS-CoV-2) RNA shedding were evaluated in cohort 113 symptomatic patients from hospitals outside Wuhan.The median (interquartile range) SARS-CoV-2 detection was 17 (13-22) days as measured illness onset. When comparing early (<15 days) late...
Moyamoya disease is an uncommon cerebrovascular disorder characterized by steno-occlusive changes in the circle of Willis and abnormal vascular network development. Ring finger protein 213 (RNF213) has been identified as important susceptibility gene for Asian patients, but researchers have not completely elucidated whether RNF213 mutations affect pathogenesis moyamoya disease. Using donor superficial temporal artery samples, whole-genome sequencing was performed to identify mutation types...
Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease characterized by leukopenia and thrombocytopenia, aspergillosis a common complication in severe cases. Previous studies have reported cases of SFTS complicated invasive pulmonary (IPA) central nervous system aspergillosis. Here, we present the first case immunocompetent patient who progressed to IPA Aspergillus endocarditis after glucocorticoid treatment, embolism vegetations from left...
In January 2015, there was an outbreak of avian-origin influenza A (H7N9) virus in Zhejiang Province, China. 45-year-old man admitted to the First Affiliated Hospital University with a high fever that had lasted 7 days, chills, and cough yellow sputum. Laboratory testing confirmed infection H7N9 virus, likely obtained from contact poultry at local live market. large dense shadow apparent patient's left lung time admission. Treatment oseltamivir (75mg twice daily) did not improve condition....
Abstract Objectives To appraise effective predictors for infection in patients with decompensated cirrhosis (DC) by using XGBoost algorithm a retrospective case-control study. Methods Clinical data were retrospectively collected from 6,648 DC admitted to five tertiary hospitals. Indicators significant differences determined univariate analysis and least absolute contraction selection operator (LASSO) regression. Further multi-tree extreme gradient boosting (XGBoost) machine learning-based...
This work aims to explore the long-term prognosis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). In this prospective study, eligible inpatients with HBV-ACLF are enrolled and followed up from December 2012 February 2023, for clinical events, laboratory tests at least every 6 months. Overall, survival rates 28 days, 90 1 year, 5 years, 8 years 64.7%, 48.8%, 46.1%, 43.8%, 42.2%, respectively. Among 8-year mortality transplant cases, ACLF survivors (who survived over...
Parthenolide (PTL) shows potent anti-inflammatory and anti-cancer activities. In the present study, molecular mechanisms of PTL's activities were explored in lipopolysaccharide (LPS)-induced human leukemia monocytic THP-1 cells primary monocytes. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium salt (MTS) assay was used to analyze effect PTL on cell viability. Enzyme-linked immunosorbent determine LPS-induced inflammatory cytokine secretion. Flow...
The H7N9 influenza virus caused significant mortality and morbidity in humans during an outbreak China 2013. A recombinant seed with hemagglutinin (HA) neuraminidase (NA) gene segments from A/Zhejiang/DTID-ZJU01/2013(H7N9) six internal protein A/Puerto Rico/8/34(H1N1; PR8) were generated using reverse genetics. We sought to determine the immunogenic, protective properties, mechanisms of a split avian A/H7N9 vaccine mixed MF59 adjuvant comparison vaccines that included other adjuvant. BALB/c...
Background: To determine the safety and immunogenicity of a novel recombinant adenovirus type 5 vector based Ebola virus disease vaccine (Ad5-EBOV) in Africans China.Methods: A phase 1, dose-escalation, open-label trial was conducted. 61 healthy were sequentially enrolled, with 31 participants receiving one shot intramuscular injection 30 double-shot regimen. Primary secondary end points related to assessed within 28 d after vaccination. This study registered ClinicalTrials.gov...
Background: The urgency of the 2019 novel coronavirus outbreak has led to demand effective antiviral agents. Preliminary experiment indicated that Arbidol concentrations might inhibit replication in vitro. However, there was limited data about clinical efficacy coronavirus-infected pneumonia (NCP). Methods: We did a retrospective cohort study NCP patients who received empiric al regimens with or without Arbidol. A total 111 from two centers China were enrolled. Findings: Among these...
Abstract Background Progressive multiple sclerosis (PMS) is an uncommon and severe subtype of MS that worsens gradually leads to irreversible disabilities in young adults. Currently, there are no applicable or reliable biomarkers distinguish PMS from relapsing–remitting (RRMS). Previous studies have demonstrated dysfunction N 6-methyladenosine (m6A) RNA modification relevant many neurological disorders. Thus, the aim this study was explore diagnostic for based on m6A regulatory genes...
Abstract Introduction Gestational diabetes mellitus (GDM) is associated with a higher risk of adverse maternal outcomes, but its effects on and perinatal outcomes twin pregnancies remain conflicting. Methods This retrospective cohort study included all primipara who delivered at single tertiary center between January 1, 2016 December 31, 2022. Excluded were those had pregnancy, pre-existing diabetes, missing information GDM screening, delivery before gestational 28 weeks, complications...
Host-virus interactions can significantly impact the viral life cycle and pathogenesis; however, our understanding of specific host factors involved in highly pathogenic avian influenza A virus H7N9 (HPAI H7N9) infection is currently restricted. Herein, we designed synthesized 65 small interfering RNAs targeting genes potentially associated with various aspects RNA cycles. Afterward, HPAI viruses were isolated interference was used to screen for likely be H7N9. Moreover, research entailed...
The present study evaluated the potential combined effects of NAFLD and MetS on development osteoporosis. relationship between osteoporosis was assessed in 938 postmenopausal female participants. Moderate severe NAFLDs were as significant (SNAFLD). All subjects divided into 4 subgroups based status SNAFLD MetS. Relative excess risk interaction (RERI), attributable proportion (AP) interaction, synergy index (SI) used to investigate additive those two factors. NAFLD, SNAFLD, independent...
Increased oxidative stress levels play a key role in idiosyncratic drug-induced liver injury (DILI) pathogenesis. To investigated whether advanced oxidation protein products (AOPPs) and ischaemia-modified albumin (IMA) can be used to monitor DILI patients assess disease severity. We performed spectrophotometric assays AOPPs IMA 68 with severity grade 0-2 (non-severe group), 60 3-5 (severe 38 healthy controls. The results showed that baseline serum AOPPs/albumin IMA/albumin ratios were...