A5101661151- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Influenza Virus Research Studies
- Blood Pressure and Hypertension Studies
- Trace Elements in Health
- Immune Response and Inflammation
- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Mesenchymal stem cell research
- Viral Infections and Immunology Research
- Organ Transplantation Techniques and Outcomes
- HIV, Drug Use, Sexual Risk
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Sodium Intake and Health
- Viral gastroenteritis research and epidemiology
- Heavy Metal Exposure and Toxicity
- Tissue Engineering and Regenerative Medicine
- HIV/AIDS Research and Interventions
- Nutrition and Health in Aging
- Adolescent Sexual and Reproductive Health
- Virology and Viral Diseases
- Animal Disease Management and Epidemiology
- Liver physiology and pathology
- Plant responses to water stress
Beijing Institute of Technology
2024
Tianjin Medical University General Hospital
2011-2024
Huazhong University of Science and Technology
2020-2024
Hunan Agricultural University
2024
Union Hospital
2022-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2022-2024
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
Shanghai Veterinary Research Institute
2017-2022
Chinese Academy of Agricultural Sciences
2022
Abstract Liver fibrosis affects approximately 800 million patients worldwide, with over 2 deaths each year. Nevertheless, there are no approved medications for treating liver fibrosis. In this study, we investigated the impacts of ginkgetin on and underlying mechanisms. The were assessed in mouse models induced by thioacetamide or bile duct ligation. Experiments human LX‐2 cells primary hepatic stellate (HSCs) performed to explore mechanisms, which also validated models. Ginkgetin...
Cytokines play an important role in the pathogenesis of hypertension. The authors hypothesized that interleukin 17 ( IL ‐17) might contribute to prehypertensive state. This study evaluated relationship between serum levels ‐17 and prehypertension. A total 394 participants were enrolled, after excluding for hypertension or treated hypertension, divided into two groups (optimal blood pressure [ BP ] prehypertension) based on Seventh Report Joint National Committee Prevention, Detection,...
This study aimed to design a VEGFR-targeting peptide-drug conjugate with the ability decrease tumor burden and suppress angiogenesis, further evaluate therapeutic effect of anti-PD-1 antibody in HCC therapy. A peptide VEGF
The H7N9 influenza virus caused significant mortality and morbidity in humans during an outbreak China 2013. A recombinant seed with hemagglutinin (HA) neuraminidase (NA) gene segments from A/Zhejiang/DTID-ZJU01/2013(H7N9) six internal protein A/Puerto Rico/8/34(H1N1; PR8) were generated using reverse genetics. We sought to determine the immunogenic, protective properties, mechanisms of a split avian A/H7N9 vaccine mixed MF59 adjuvant comparison vaccines that included other adjuvant. BALB/c...
To examine the association of self-reported sleep duration and hypertension using data from Tianjin China.Participants aged 40-70 years without were recruited with a stratified cluster sampling method across six districts Tianjin, China. Information regarding their sociodemographic lifestyle-related characteristics was gathered by questionnaires. After 2 follow-up, second physical examination taken on same crowd.During 2-year period, 874 subjects (221 men, 653 women) successfully contacted....
Objective To determine the prevalence and distribution of human enteroviruses (HEVs) among healthy children in Shenzhen, China. Method Clinical specimens were obtained from 320 under 5 years old China 2010 to 2011. The evaluated using real-time PCR cell cultures. positive further tested reverse transcription-seminested (RT-snPCR). Molecular typing phylogenetic analysis based on sequence determined. Results Among samples, 34 for HEVs (10.6%) 22 different serotypes identified RT-snPCR. PV1 PV2...
BACKGROUND:The aims of this study were to investigate the relationship between optimal anthropometric indices and their cut-off values incidence hypertension in a cohort middle-aged women China. MATERIAL AND METHODS:A 812 women, aged 40–70 years recruited May 2011 June 2013. An ideal baseline blood pressure was defined as <120/80 mmHg; pre-hypertension 120–139/80–89 ≥140/≥90 mmHg. Anthropometric measurements included waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR),...
Background and aims: Hyperuricemia is an independent risk factor for hypertension. This study aims to investigate whether SUA predicts 2-year incidence of hypertension in population with pre-hypertension ideal blood pressure Tianjin, China. Methods results: In this population-based prospective study, we analyzed 608 subjects (455 women) aged 40–70 non-hypertension (SBP < 140 mmHg DBP 90 mmHg) who were recruited stratified cluster sampling method across six districts Tianjin 2011–2012....
Plants NADP-malic enzymes (NADP-MEs) act as a class of oxidative decarboxylase to mediate malic acid metabolism in organisms. Despite NADP-MEs have been demonstrated play pivotal roles regulating diverse biological processes, the role involving plant growth and development remains rarely known. Here, we characterized function rice cytosolic OsNADP-ME2 height. The results showed that RNAi silencing knock-out dwarf structure, associating with significant expression inhibition genes...
When included in a sequential polio vaccination schedule, inactivated vaccine (IPV) reduces the risk for vaccine-associated paralytic poliomyelitis (VAPP), rare adverse event associated with receipt of oral poliovirus (OPV). During January 2014, World Health Organization (WHO) recommended introduction at least 1 IPV dose into routine immunization schedules OPV-using countries (1). The Polio Eradication and Endgame Strategic Plan 2013-2018 completion 2015 globally synchronized withdrawal OPV...
The influenza virus is a serious threat to public health worldwide. A novel avian (H7N9) with mortality rate of approximately 30% has been identified as an unusually dangerous for humans by the World Health Organization. Pathogenic H7N9 continue represent concern, and several candidate vaccines are currently in development. We generated vaccine strains using reverse genetics, consisting hemagglutinin neuraminidase genes derived from human remaining PR8 (A/PuertoRico/8/34 (H1N1)) virus. This...
Since the first case of novel H7N9 infection was reported, China has experienced five epidemics H7N9. During fifth wave, a highly pathogenic strain emerged. In order to assess whether vaccine based on A/Zhejiang/DTID-ZJU01/2013(H7N9) effective in protecting against H7N9, we conducted this study.Groups mice were immunized twice by intraperitoneal injection with 500 µl either split alone or MF59-adjuvanted vaccine. Serum collected 2 weeks after second booster. The hemagglutinin inhibition test...
Velogenic Newcastle disease virus (NDV) causes encephalitis and severe neurological disorders in avian species. Sialic acid (SA) has been considered as a receptor for NDV infection determining tissue tropism. The neurotropic mechanism of birds is completely unknown. Here we have investigated the role viral SA neurotropism chickens. We determined that α2,3- α2,6-linked receptors were implicated binding to primary neuronal cells using immunohistofluorescence virus-cell assay. Both found...
Background: Prehypertension has been reported as being correlated with future cardiovascular risk and end-organ damage in middle-aged elderly persons, also playing an important role metabolic syndrome (MetS). The association between prehypertension MetS rarely among urban adults Tianjin, China. Methods: In this cross-sectional study, a total of 1176 participants aged 40–70 years (524 males 652 females) were enrolled after excluding hypertension or treated hypertension. Participants divided...
Study suggested that elevated homocysteine showed a multiplicative effect on cardiovascular diseases in hypertensive subjects. It was reported level independently associated with increased arterial stiffness prehypertensives. remains unclear whether prehypertensives combined have adverse risk factors. We aimed to compare cardiometabolic profile between hyperhomocysteinaemia and those without either condition.Plasma total were determined among 874 Chinese non-hypertension individuals Tianjin....