A5048982364- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Statistical Methods and Bayesian Inference
- Viral Infections and Immunology Research
- Soil and Water Nutrient Dynamics
- Statistical Methods in Clinical Trials
- Migration, Aging, and Tourism Studies
- Escherichia coli research studies
- Intergenerational Family Dynamics and Caregiving
- Antimicrobial Resistance in Staphylococcus
- Health disparities and outcomes
- Soil Geostatistics and Mapping
- Streptococcal Infections and Treatments
- Biosimilars and Bioanalytical Methods
- Viral Infections and Vectors
- Medical Research and Treatments
- Hepatitis C virus research
- Pediatric health and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Survey Methodology and Nonresponse
- Allergic Rhinitis and Sensitization
- Zoonotic diseases and public health
- Statistical Methods and Inference
- Respiratory and Cough-Related Research
Bristol-Myers Squibb (United States)
2023-2024
Central South University
2024
Beijing Children’s Hospital
2022
Iowa State University
2021
Beijing Center for Disease Prevention and Control
2014-2020
Jingdong (China)
2017
In China, great differences in economy, social characteristics and hygiene exist between developing developed regions. A comparative study of infectious diarrhea two regions was needed. Three groups diarrheal patients were collected: children ≤5 year-olds from Beijing (developed region) Henan Province (developing region), adults over 18 Beijing. questionnaire used to survey feces samples examined for 16 enteropathogens. We enrolled 1422 1047 region 755 region. Virus positive rates 32.98%...
When included in a sequential polio vaccination schedule, inactivated vaccine (IPV) reduces the risk for vaccine-associated paralytic poliomyelitis (VAPP), rare adverse event associated with receipt of oral poliovirus (OPV). During January 2014, World Health Organization (WHO) recommended introduction at least 1 IPV dose into routine immunization schedules OPV-using countries (1). The Polio Eradication and Endgame Strategic Plan 2013-2018 completion 2015 globally synchronized withdrawal OPV...
Abstract Many large‐scale surveys collect both discrete and continuous variables. Small‐area estimates may be desired for means of variables, proportions in each level a categorical variable, or domain defined as the mean variable variable. In this paper, we introduce conditionally specified bivariate mixed‐effects model small‐area estimation, provide necessary sufficient condition under which conditional distributions render valid joint distribution. The specification allows better...
Abstract Many surveys collect information on discrete characteristics and continuous variables, that is, mixed-type variables. Small-area statistics of interest include means or proportions the response variables as well their domain means, which are mean values at each level a different categorical variable. However, item nonresponse in survey data increases complexity small-area estimation. To address this issue, we propose multivariate mixed-effects model for subject to nonresponse. We...
Objective: To illuminate the epidemic characteristics of Yersiniosis among children in central city Beijing and accuracy current clinical diagnosis towards Yersiniosis. Methods: Etiological surveillance diarrheal patients, a total 3 493 cases, was performed hospital area from 2011 to 2018 continuously. Collected epidemiological information analyzed etiological for bacterial dysentery compared distribution cases with different symptoms. Results: A acute diarrhea distributed age 6 months 13...
ABSTRACT Immunotherapies and targeted therapies have gained popularity due to their promising therapeutic effects across multiple treatment areas. The focus of early phase dose‐finding clinical trials has shifted from finding the maximum tolerated dose (MTD) identifying optimal biological (OBD), which aims balance toxicity efficacy outcomes, thus optimizing risk–benefit trade‐off. These often collect pharmacokinetics (PK) outcomes assess drug exposure, shown correlations with but not been...
Danwei communities are a testament to China's socialist urban development, characterized by the self-sufficiency, strong social networks, and institutional management. In historical context of development in China, many old have evolved from former housing areas Danwei. After more than 40 years use, buildings, environments remain disrepair, dirty, disorderly poor condition. Many functions failed that negatively affect quality life health residents. Covid-19, improving mental residents has...
ABSTRACT In this study, 52 Streptococcus suis isolates from pigs in southern China were divided into four known sequence types (STs) and six new STs, using multilocus typing. Ten representative selected 10 STs for the analysis of whole genome sequences. Virulence was assessed isolates, which classified three pathogenic groups. The prevalence virulence-associated factors moderately group higher than that highly group. ST1 complex serotype 2 allocated to group, while belonged non-ST1...
Objective To investigate the main pathogens of viral diarrhea in children under 5 years old Dongcheng District Beijing. Methods From October 2011 to September 2015, 1 754 fecal specimens with were collected second maternal and child health care hospital District. RT-PCR PCR used detect Rotavirus (HRV), norovirus (NV), sapovirus (SAV), enteric Adenovirus (EAdV) astrovirus (AstV). Results Among specimens, 632 positive total detection rate was 36.0% (632/1 754). The HRV, NV, SPV,...
Objective: To understand the characteristics and differences of diarrhea-related symptoms caused by different pathogens, clinical features various pathogens causing diarrhea. Methods: Etiology surveillance program was conducted among 20 provinces China from 2010 to 2016. The acute diarrhea outpatients were collected clinics or hospitals. A questionnaire used survey demographics features. VFeces samples taken for laboratory detection 22 common detect analyze symptom pattern patient's....
Objective To study the incidence of hand-foot-mouth disease,and explore prevention and control measures HFMD.Methods The epidemiological characteristics 380 cases with handfoot-mouth disease in southern branch Dong-cheng district were analyzed according to data collected through China information system for diseases prevention.Results There HFMD (southern branch) 2012,and was 106.1/105.All seven streets had reported.There reported all year.Summer is peak season.Main patients 0-5 years old...
Abstract Background There are a limited number of validated questionnaires available for use in the clinical screening allergic rhinitis (AR) children ≤3 years old. We developed novel self‐reported questionnaire and assessed its accuracy reliability. Methods After establishing pool items, which were screened by experts, Young Children Allergic Rhinitis Questionnaire (YCAR‐Q) was administered to birth cohort Shunyi District (Beijing, China). The electronic version YCAR‐Q distributed through...