A5100740382- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Nail Diseases and Treatments
- Selenium in Biological Systems
- Cancer Immunotherapy and Biomarkers
- Plant Pathogens and Fungal Diseases
- Cancer-related molecular mechanisms research
- Phytoestrogen effects and research
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- HER2/EGFR in Cancer Research
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- Reproductive System and Pregnancy
- Bladder and Urothelial Cancer Treatments
- Ocular Oncology and Treatments
- Autoimmune Bullous Skin Diseases
- Immune cells in cancer
- Bacterial Infections and Vaccines
- Estrogen and related hormone effects
- Temporomandibular Joint Disorders
- Trace Elements in Health
- Oropharyngeal Anatomy and Pathologies
Kunming Medical University
2019-2025
Affiliated Hospital of Qingdao University
2025
Qingdao University
2025
First Affiliated Hospital of Zhengzhou University
2024
Northeastern University
2023-2024
Guangxi Medical University
2013-2024
Tumor Hospital of Xinjiang Medical University
2024
Northeastern University
2019-2024
Shaanxi University of Chinese Medicine
2024
Xuzhou Medical College
2024
Cryptococcus neoformans is an opportunistic yeast that kills over 625,000 people yearly through lethal meningitis. Host phagocytes serve as the first line of defense against this pathogen, but fungal engulfment and subsequent intracellular proliferation also correlate with poor patient outcome. Defining interactions facultative pathogen host key to understanding latter's opposing roles in infection how they contribute latency, dissemination, virulence. We used high-content imaging a human...
Objective Systemic lupus erythematosus (SLE) is an autoimmune disease with complex etiology that not yet entirely understood. We aimed to elucidate the mechanisms and therapeutic potential of microRNAs (miRNAs) in SLE a Tibetan population. Methods Peripheral blood mononuclear cells from patients (n = 5) healthy controls were used for miRNA–mRNA co-sequencing detect miRNAs related immune abnormalities associated SLE. Luciferase reporter assay was identify targets candidate miRNA. The target...
Cryptococcus neoformans poses a threat to human health, but anticryptococcal therapy is hampered by the emergence of drug resistance, whose underlying mechanisms remain poorly understood. Herein, we discovered that Isw1, an imitation switch chromatin remodeling ATPase, functions as master modulator genes responsible for in vivo and vitro multidrug resistance C. neoformans. Cells with disrupted ISW1 gene exhibited profound multiple antifungal drugs. Mass spectrometry analysis revealed Isw1...
Pueraria thomsonii Benth is an important medicinal plant. Transcriptome sequencing, unigene assembly, the annotation of transcripts and study gene expression profiles play vital roles in function research. However, full-length transcriptome P. remains unknown. Here, we obtained 44,339 nonredundant by using PacBio RS II Isoform Illumina sequencing platforms, which 43,195 were annotated genes. Compared with levels plant roots, those a |fold change| ≥ 4 FDR < 0.01 leaves or stems assigned as...
Abstract Background A combination of immune checkpoint inhibitors (ICIs) and chemotherapy has demonstrated excellent clinical efficacy safety in treating a variety cancers, including urothelial carcinoma (UC). However, its patients with muscle-invasive upper tract (UTUC) who are undergoing radical surgery remain uncertain. The purpose this retrospective study was to examine the effectiveness tislelizumab combined gemcitabine plus cisplatin (TGC) as first-line postoperative adjuvant treatment...
Deep eutectic solvents (DESs)-based ultrasonic extraction of terpene trilactones (TTLs) from Ginkgo biloba leaves was efficiently developed. Sixteen DESs were prepared, and composed choline chloride-urea (ChCl-U) betaine-ethylene glycol (BE-EG) gave higher TTL yields than the present, most efficient solvent 70% ethanol. The conditions further optimized, optimum as follows: taking BE-EG containing 40% (w/w) water solvent, 1:10 G. powder-to-solvent ratio, treatment at 45°C 100 W for 20 min. A...
Pathogens and hosts require rapid modulation of virulence defense mechanisms at the infection axis, but monitoring such modulations is challenging. In studying human fungal pathogen Cryptococcus neoformans, mouse rabbit models are often employed to shed light on disease that may not be clinically relevant. this study, we developed an animal model using non-human primate cynomolgus monkey Macaca fascicularis. addition, systematically profiled compared transcriptional responses between...
Background Systemic lupus erythematosus is an immunologically dysregulated disease characterized by the presence of multiple autoantibodies. In SLE, B lymphocytes contribute to production autoantibodies and cytokines. Recently, we discovered that miR-99a-3p binds both EIF4EBP1 NCAPG mRNA lowering can promote cell autophagy in SLE increasing expression. However, functions have not been extensively investigated. Objective This work aims evaluate levels expression cells determine whether...
Abstract Background In the management of urothelial carcinoma, patient selection for immunotherapy, particularly with immune checkpoint inhibitors such as PD-1 (programmed cell death protein 1), is important treatment efficacy. Inflammatory markers are useful predicting outcomes and immune-related adverse events (irAEs). This study aims to retrospectively explore associations between inflammatory in patients postoperative carcinoma undergoing tislelizumab (PD-1 inhibitor) adjuvant therapy....
Understanding the changes in pore structure of reservoirs presence CO2 is critical for carbon neutrality, especially shale oil with ultra-low permeability and porosity. However, studies examining alteration that have been treated remain limited. Thus, this paper, nuclear magnetic resonance (NMR) low-temperature nitrogen adsorption (LNA) technologies were employed to address issue. The results show porosity increase after exposure CO2. improves by 49.03%, increases 29.54%. NMR reveal altered....
e16565 Background: EGFR-targeted ADCs have demonstrated preliminary efficacy in Urothelial carcinoma (UC). UC with squamous differentiation (UCSC) is typically classified as basal type, which associated increased expression of EGFR. This study explores the differences EGFR between UCSC and pure by IHC correlation different scores prognosis. Methods: Patients diagnosed from our center were collected matched patients UC. Use to compare levels HER-2 2 groups, evaluate survival rates these...
Background Cryptococcus neoformans causes serious disease in immunocompromised individuals, leading to over 600,000 deaths per year worldwide. Part of this impact is due the organism's ability thwart what should be mammalian hosts' first line defense against cryptococcal infection: internalization by macrophages. Even when C. engulfed host phagocytes, it can survive and replicate within them rather than being destroyed; central virulence. It therefore critical elucidate interactions...
CCDC134 is a poorly characterized secreted protein that may act as an immune cytokine. Here, we show differentially expressed on resting and activated cells it promotes CD8(+) T-cell activation, proliferation, cytotoxicity by augmenting expression of the effector molecules IFNγ, TNFα, granzyme B, perforin. facilitated infiltration T with enhanced cytolytic activity into tumors, demonstrating strong antitumor effects in T-cell-dependent manner. Mechanistically, cells, exposure to promoted...