A5064735710- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Phytochemical Studies and Bioactivities
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactive Compounds
- Meta-analysis and systematic reviews
- Ginkgo biloba and Cashew Applications
- Peptidase Inhibition and Analysis
- Single-cell and spatial transcriptomics
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Beijing University of Chinese Medicine
2016-2025
Chinese Academy of Sciences
2001-2025
University of Chinese Academy of Sciences
2019-2025
Wenzhou Medical University
2025
Dalian University
2025
Yuncheng University
2025
Guangzhou Sport University
2022-2025
Center for Excellence in Molecular Cell Science
2001-2025
Shandong Academy of Sciences
2023-2025
Abstract Pharmacotranscriptomics has become a powerful approach for evaluating the therapeutic efficacy of drugs and discovering new drug targets. Recently, studies traditional Chinese medicine (TCM) have increasingly turned to high-throughput transcriptomic screens molecular effects herbs/ingredients. And numerous examined gene targets herbs/ingredients, link herbs/ingredients various modern diseases. However, there is currently no systematic database organizing these data TCM. Therefore,...
Perivascular adipose tissue (PVAT) surrounds most vessels and shares common features with brown (BAT). Although adaptive thermogenesis in BAT increases energy expenditure is beneficial for metabolic diseases, little known about the role of PVAT vascular diseases such as atherosclerosis. We hypothesize that thermogenic function regulates intravascular temperature reduces atherosclerosis.PVAT similar structural proteomics BAT. demonstrated has properties to response cold stimuli vivo....
This paper reports the construction of synchronization criteria for delayed impulsive epidemic models with reaction–diffusion under Neumann boundary value. Different from previous literature, model a impulse brings mathematical difficulties to this paper. In fact, due existence second-order partial derivatives in impulse, methods first-order ordinary differential equations literature cannot be effectively applied However, help variational method and an appropriate boundedness assumption, new...
Abstract Background With extended gefitinib treatment, the therapeutic effect in some non-small cell lung cancer (NSCLC) patients declined with development of drug resistance. Aidi injection (ADI) is utilized various cancers as a traditional Chinese medicine prescription. This study explores molecular mechanism by which ADI, when combined gefitinib, attenuates resistance PC9GR NSCLC cells. Methods In vitro and vivo pharmacological experiments were conducted cells NSG mice cell-derived...
Background and Objective: Despite striking advances in multimodality management, gastric cancer (GC) remains the third cause of mortality globally identifying novel diagnostic prognostic biomarkers is urgently demanded. The study aimed to identify potential key genes associated with pathogenesis prognosis GC. Methods: Differentially expressed between GC normal tissue samples were screened by an integrated analysis multiple gene expression profile datasets. Key related identified employing...
As more and high-throughput data has been produced by next-generation sequencing, it is still a challenge to classify RNA transcripts into protein-coding or non-coding, especially for poorly annotated species. We upgraded our original coding potential calculator, CNCI (Coding-Non-Coding Index), CNIT Identifying Tool), which provides faster accurate evaluation of the ability transcripts. runs ∼200 times than exhibits accuracy compared with (0.98 versus 0.94 human, 0.95 0.93 mouse, 0.92...
Background and Objective: Non-small cell lung cancer (NSCLC) accounts for 80-85% of all patients with 5-year relative overall survival (OS) rate is less than 20%, so that identifying novel diagnostic prognostic biomarkers urgently demanded. The present study attempted to identify potential key genes associated the pathogenesis prognosis NSCLC. Methods: Four GEO datasets (GSE18842, GSE19804, GSE43458, GSE62113) were obtained from Gene Expression Omnibus (GEO) database. differentially...
This multicenter phase-II trial aimed to investigate the efficacy, safety, and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC. Patients who failed from first-line EGFR-TKIs did not harbor T790M mutation were enrolled. Toripalimab carboplatin pemetrexed administrated every three weeks for up six cycles, followed by maintenance pemetrexed. The primary endpoint was objective-response rate (ORR). Integrated biomarker...
Lung adenocarcinoma (LUAD) is the most prevalent subtype of non-small cell lung cancer. Additionally, disulfidptosis, a newly discovered type death, has been found to be closely associated with onset and progression tumors. The study first identified genes related disulfidptosis through correlation analysis. These were then screened using univariate cox regression LASSO regression, prognostic model was constructed multivariate regression. A nomogram also created predict prognosis LUAD....
Rheumatoid arthritis (RA) is a common chronic immune disease. Berberine, as its main active ingredient, was also contained in variety of medicinal plants such Berberaceae, Buttercup, and Rutaceae, which are widely used digestive system diseases traditional Chinese medicine with anti-inflammatory antibacterial effects. The aims this article were to explore the therapeutic effect mechanism berberine on rheumatoid arthritis.Cell Counting Kit-8 evaluate proliferation RA fibroblast-like...
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating of the central nervous system. This study aimed to delineate clinical manifestations, imaging features, and long-term outcomes in Chinese patients with MOGAD analyze recurrence-associated factors. The phenotypic neuroimaging characteristics 15 Han were retrospectively analyzed. Demyelinating attacks, MOG antibodies cerebrospinal fluid/serum, response immunotherapy,...
Upon differentiation induction of 3T3-L1 preadipocytes by a hormone mixture containing 1-isobutyl-3-methylxanthine, dexamethasone, and insulin, the undergo ∼2 rounds mitotic clonal expansion, which just precedes adipogenic gene expression program has been thought to be an essential early step for initiation. By inducing with each individual hormone, it was determined that expansion induced only insulin not 1-isobutyl-3-methylxanthine or dexamethasone. Cell number counting...
Abstract Background Network meta-analysis (NMA) has been widely used in the field of medicine and health, but research topics development trends are still unclear. This study aimed to identify cooperation countries institutes explore hot future prospects NMA. Methods Data publications were downloaded from Web Science Core Collection. We CiteSpace V, HistCite 2.1, Excel 2016 analyze literature information, including years, journals, countries, institutes, authors, keywords, co-cited...
Abstract Stomach adenocarcinoma (STAD) is a type of cancer which often at itsadvanced stage apon diagnosis and mortality in clinical practice. Several factors influencethe prognosis STAD, including the expression regulation immune cells tumor microenvironment. We here investigated biomarkers related to gastric cancer, hoping provide insights for treatment future. STAD normal patient RNA sequencing data sets were accessed from genome atlas (TCGA database). Differential genes determined...