A5100435139- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Diabetes Treatment and Management
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Head and Neck Anomalies
- Hepatitis C virus research
- Metastasis and carcinoma case studies
- Acute Myeloid Leukemia Research
- Inflammasome and immune disorders
- Cardiovascular Function and Risk Factors
First Affiliated Hospital of Dalian Medical University
2013-2025
Guangxi University
2025
Southern Medical University
2014-2025
Hubei University of Medicine
2025
Ruijin Hospital
2013-2025
Chinese PLA General Hospital
2024-2025
Yantai University
2016-2025
Shanghai Jiao Tong University
2017-2025
Jiangsu University
2023-2025
Affiliated Hospital of Jiangsu University
2024-2025
Abstract Tumor microenvironment (TME) cells constitute a vital element of tumor tissue. Increasing evidence has elucidated their clinicopathologic significance in predicting outcomes and therapeutic efficacy. Nonetheless, no studies have reported systematic analysis cellular interactions the TME. In this study, we comprehensively estimated TME infiltration patterns 1,524 gastric cancer patients systematically correlated phenotypes with genomic characteristics features using two proposed...
Tumour-infiltrating immune cells are a source of important prognostic information for patients with resectable colon cancer. We developed novel model based on systematic assessments the landscape inferred from bulk tumor transcriptomes stage I-III cancer patients. The "Cell type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT)" algorithm was used to estimate fraction 22 cell types six microarray public datasets. random forest method and least absolute shrinkage...
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have favorable cardiovascular outcomes in patients with diabetes. However, whether SGLT2i can improve obesity-related cardiac dysfunction is unknown. Sestrin2 a novel stress-inducible protein that regulates AMPK-mammalian target of rapamycin (mTOR) and suppresses oxidative damage. The aim this study was to determine empagliflozin (EMPA) improves via regulating Sestrin2-mediated pathways diet-induced obesity. C57BL/6J mice knockout were fed...
Importance Diabetes in children is a global epidemic that causes various medical conditions associated with an increased incidence of premature death. Objective To investigate the trends diabetes incidence, mortality, and disability-adjusted life-years (DALYs) children, risk factors for diabetes-associated death, from 1990 to 2019. Design, Setting, Participants This was cross-sectional study used data Global Burden Diseases (GBD) 2019 204 countries territories. Children who were aged 0 14...
Immunotherapy is a revolutionized therapeutic strategy for tumor treatment attributing to the rapid development of genomics and immunology, immune checkpoint inhibitors have successfully achieved responses in numbers types, including hematopoietic malignancy. However, acute myeloid leukemia (AML) heterogeneous disease there still lack systematic demonstration apply immunotherapy AML based on PD-1/PD-L1 blockage. Thus, identification molecules that drive immunosuppression stratify patients...
Cardiomyopathy encompasses a broad spectrum of diseases affecting myocardial tissue, characterized clinically by abnormalities in cardiac structure, heart failure, and/or arrhythmias. Clinically heterogeneous, major types include dilated cardiomyopathy (DCM), hypertrophic (HCM), restrictive (RM), ischemic (ICM), among which DCM is more prevalent, while ICM exhibits higher incidence and mortality rates. Myocardial injury during progression may lead to fibrosis. Failure intervene early inhibit...
Here, we reported a highly efficient nitrate electroreduction (NO3RR) electrocatalyst that integrated alloying and heterostructuring strategies comprising FeCo alloy Mo0.82N (FeCo-Mo0.82N/NC). Notably, the maximum NH3 Faraday efficiency (FE) of 83.24%, yield 12.28 mg h-1 mgcat.-1, good stability were achieved over FeCo-Mo0.82N/NC. Moreover, Zn-NO3- battery assembled with FeCo-Mo0.82N/NC exhibited power density 0.87 mW cm-2, an 14.09 FE as high 76.31%.
Aims: Prostate cancer (PCa) is one of the most commonly diagnosed cancers worldwide. Currently available therapies for metastatic PCa are only marginally effective, hence novel treatment modalities urgently required. Considerable evidence(s) suggest that deregulated activation oncogenic transcription factor, signal transducer and activator 3 (STAT3) plays a pivotal role in development progression PCa. Thus, agents can abrogate STAT3 could form basis therapy patients. In present study, we...
Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering inflammation and altering the microbiome diversity. In this study, we aimed investigate differential of three different common IF treatments, alternate day (ADF), time-restricted (TRF), intermittent energy restriction (IER), a dextran sodium sulfate (DSS)-induced colitis mouse model. The results indicated that TRF IER, but not ADF improved survival rates mice. ADF, reversed...
Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome was emerged as marker of metabolic dysregulation. We revealed that age-related Sirtuin-1 (SIRT1) modulates cardiac metabolism medicated inflammatory response during ischemia and reperfusion (I/R) stress. hypothesize SIRT1 attenuates NLRP3 inflammasome-dependent inflammation pyroptosis myocardial I/R through modulation. C57BL/6J wild type (WT) mice, inducible cardiomyocyte specific knockout...
TiO2 and ZnO are extensively used photocatalysts, but their activity needs improvement due to rapid charge recombination. Herein, we designed synthesized a novel structure of TiO2–ZnO composite sphere decorated with clusters by one-pot solvethermal method. TEM EDX characterizations show this contains core, (type II heterojunction) surface layer, c-axis clusters. The in situ Au PbO2 photodeposition shows that the photoinduced electrons holes driven TiO2, respectively, attributed synergy type...
Imatinib (IM) has been applied to the chronic phase of myeloid leukemia (CML) and great benefit on prognosis patients with CML. The function drug efflux mediated by multidrug resistance protein-1 (MDR1) is considered as a main reason for IM in CML cells. However, exact mechanisms MDR1 modulation cells remain unclear. In present study, long noncoding RNA (lncRNA) UCA1 was identified an important modulator model system cell lines gradual increase expression resistance. Overexpression increased...
Abstract Sirtuin1 (SIRT1) and Sirtuin3 (SIRT3) protects cardiac function against ischemia/reperfusion (I/R) injury. Mitochondria are critical in response to myocardial I/R injury as disturbance of mitochondrial dynamics contributes dysfunction. It is hypothesized that SIRT1 SIRT3 components maintaining mitochondria homeostasis especially exert cardioprotective actions under stress. The results demonstrated deficiency aged (24–26 months) mice hearts led the exacerbated dysfunction terms...
Our study indicates high efficiency of mNGS using BALF for the detection causative pathogens that cause pneumonia in children. can be a potential diagnostic tool to supplement conventional methods children’s pneumonia.