A5002262324- Cytokine Signaling Pathways and Interactions
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- S100 Proteins and Annexins
- Cancer Mechanisms and Therapy
- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Natural Compounds in Disease Treatment
- PI3K/AKT/mTOR signaling in cancer
- Chemokine receptors and signaling
- Peroxisome Proliferator-Activated Receptors
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- Histone Deacetylase Inhibitors Research
- Quinazolinone synthesis and applications
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Nigella sativa pharmacological applications
- Cancer-related gene regulation
- Retinoids in leukemia and cellular processes
- Phytochemistry and biological activity of medicinal plants
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Pharmacological Effects of Medicinal Plants
- Protein Degradation and Inhibitors
National University of Singapore
2016-2025
Penn State Milton S. Hershey Medical Center
2025
National University Health System
2012-2024
Directorate of Poultry Research
2021
Curtin University
2013-2015
Larkin University
2015
Emory University
2015
University of North Texas
2013
Jawaharlal Nehru Centre for Advanced Scientific Research
2013
National Cancer Centre Singapore
2013
Abstract Constitutive activation of proinflammatory transcription factors such as STAT3 and NF-κB plays a pivotal role in the proliferation survival squamous cell carcinoma head neck (HNSCC). Thus, agents that can modulate deregulated have great potential both for prevention treatment HNSCC. In present report, we investigated effects garcinol, an active component Garcinia indica on various inflammatory mediators involved HNSCC progression using lines xenograft mouse model. We found garcinol...
Constitutive activation of signal transducer and activator transcription 3 (STAT3) has been linked with proliferation, survival, invasion angiogenesis a variety human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 have potential for both prevention treatment HCC. Here we report, garcinol, polyisoprenylated benzophenone, could in HCC cell lines xenografted tumor nude mice model.Different treated garcinol the inhibition activation,...