A5086232281- Natural product bioactivities and synthesis
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Bioactive Compounds and Antitumor Agents
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Synthesis and biological activity
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Plant tissue culture and regeneration
- Cancer, Hypoxia, and Metabolism
- Berberine and alkaloids research
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Curcumin's Biomedical Applications
- Phytochemistry and biological activity of medicinal plants
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Medicinal plant effects and applications
- Herbal Medicine Research Studies
- Natural Compounds in Disease Treatment
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
Hamad Medical Corporation
2015-2023
National University of Singapore
2012-2021
Duke-NUS Medical School
2015
Yong In University
2014
Amala Institute of Medical Sciences
2009-2012
Mpala Research Center and Wildlife Foundation
2010-2011
Aims: Prostate cancer (PCa) is one of the most commonly diagnosed cancers worldwide. Currently available therapies for metastatic PCa are only marginally effective, hence novel treatment modalities urgently required. Considerable evidence(s) suggest that deregulated activation oncogenic transcription factor, signal transducer and activator 3 (STAT3) plays a pivotal role in development progression PCa. Thus, agents can abrogate STAT3 could form basis therapy patients. In present study, we...
// Kodappully Sivaraman Siveen 1,* , Kwang Seok Ahn 2,* Tina H. Ong 3 Muthu K. Shanmugam 1 Feng Li Wei Ney Yap 1,4 Alan Prem Kumar 1,4,5,6 Chee Wai Fong 7 Vinay Tergaonkar 8 Kam M Hui 3,8,9,10 and Gautam Sethi Department of Pharmacology, Yong Loo Lin School Medicine, National University Singapore, Singapore 2 College Korean Kyung Hee University, Seoul 130-701, Republic Korea Division Cellular Molecular Research, Humphrey Oei Institute Cancer Centre, 4 Science Centre for Translational 14...
// Kodappully Sivaraman Siveen 1 , Nurulhuda Mustafa 2,3 Feng Li Radhamani Kannaiyan Kwang Seok Ahn 4 Alan Prem Kumar 1,2,5,6 Wee-Joo Chng Gautam Sethi 1,3 Department of Pharmacology, Yong Loo Lin School Medicine, National University Singapore, Singapore 2 Cancer Science Institute Centre for Translational 3 Haematology-Oncology, Institute, Health System, Singapore. College Korean Kyung Hee University, Seoul, Republic Korea 5 Biomedical Sciences, Faculty Curtin Western Australia, Australia 6...
The constitutive activation of Janus Kinase/Signal Transducer and Activator Transcription (JAK/STAT) signal transduction is well elucidated in STAT3-mediated oncogenesis related to thyroid cancer considered be a plausible therapeutic target. Hence, we investigated whether curcumin, natural compound, can target the JAK/STAT3 signaling pathway induce cytotoxic effects papillary (PTC) cell lines (BCPAP TPC-1) derived stem-like cells (thyrospheres). Curcumin suppressed PTC survival...
Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the clonal proliferation lymphoid precursors with arrested maturation. Although chemotherapeutic approaches have been achieving successful remission for majority cases childhood ALL, development resistance to chemotherapy has observed. Thus, new therapeutic are required improve patient's prognosis. Therefore, we investigated anticancer potential curcumin in ALL. We tested panel B-precursor ALL (B-Pre-ALL)...
Constitutive activation of signal transducer and activator transcription signalling 3 (STAT3) has been linked with survival, proliferation angiogenesis in a wide variety malignancies including hepatocellular carcinoma (HCC).We evaluated the effect lupeol on STAT3 cascade its regulated functional responses HCC cells.Lupeol suppressed constitutive phosphorylation at tyrosine 705 residue effectively dose- time-dependent manner. The Janus-activated kinases (JAKs) 1 2 Src was also by lupeol....
Platinum compounds such as cisplatin and carboplatin are frequently used the first-line chemotherapy for treatment of head neck squamous cell carcinoma (HNSCC). In present study, we investigated whether garcinol, a polyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin. We found that garcinol inhibited viability panel diverse lines, enhanced apoptotic effect cisplatin, suppressed constitutive well cisplatin-induced NF-κB activation, downregulated expression various oncogenic...
Persistent activation of signal transducer and activator transcription 3 (STAT3) is one the characteristic features renal cell carcinoma (RCC) often linked to its deregulated proliferation, survival, angiogenesis. In present report, we investigated whether zerumbone, a sesquiterpene, exerts anticancer effect through modulation STAT3 pathway. The pharmacological zerumbone on activation, associated protein kinases phosphatase, apoptosis was using both RCC lines xenograft mouse model. We...
TNF is a pleotropic cytokine known to be involved in the progression of several pro-inflammatory disorders. Many therapeutic agents have been designed counteract effect rheumatoid arthritis as well number cancers. In present study we synthesized and evaluated anti-cancer activity novel biscoumarins vitro vivo. Among new compounds, BIHC was found most cytotoxic agent against HepG2 cell line while exhibiting less toxicity toward normal hepatocytes. Furthermore, inhibited proliferation various...