A5103078041- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fungal Infections and Studies
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
- Asthma and respiratory diseases
- Multiple Myeloma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Child and Adolescent Psychosocial and Emotional Development
- Congenital Heart Disease Studies
- Blood Pressure and Hypertension Studies
- Kruppel-like factors research
- Lipid metabolism and disorders
- COVID-19 epidemiological studies
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Chemical Synthesis and Analysis
- Epigenetics and DNA Methylation
- Intensive Care Unit Cognitive Disorders
- Crystallography and molecular interactions
- Sepsis Diagnosis and Treatment
- COVID-19 Pandemic Impacts
- Renal Diseases and Glomerulopathies
First Affiliated Hospital of Guangzhou Medical University
2023-2025
State Key Laboratory of Respiratory Disease
2023-2025
Guangzhou Medical University
2023-2025
GlaxoSmithKline (United States)
2019-2025
Southern Medical University
2023-2025
Sun Yat-sen University
2022-2025
National Clinical Research
2024
Linkou Chang Gung Memorial Hospital
2024
Chang Gung University
2024
Collaborative Group (United States)
2024
ABSTRACT Background The effects of the sodium-glucose co-transporter 2 inhibitor empagliflozin on renal and cardiovascular disease have not been tested in a dedicated population people with chronic kidney (CKD). Methods EMPA-KIDNEY trial is an international randomized, double-blind, placebo-controlled assessing whether 10 mg daily decreases risk progression or death CKD. People without diabetes mellitus (DM) were eligible provided they had estimated glomerular filtration rate (eGFR) ≥20 but...
Baseline findings from the China Dialysis Calcification Study (CDCS) revealed a high prevalence of vascular calcification (VC) among patients with end-stage kidney disease; however, data on VC progression were limited. To understand at different anatomical sites, identify risk factors for progression, and assess association cardiovascular events death receiving maintenance dialysis. This cohort study was 4-year follow-up assessment participants in CDCS, nationwide multicenter prospective...
Abstract Identifying pharmacological probes for human proteins represents a key opportunity to accelerate the discovery of new therapeutics. High-content screening approaches expand ligandable proteome offer potential expedite novel chemical study protein function. Screening libraries reactive fragments by chemoproteomics offers compelling approach ligand discovery, however, optimising sample throughput, proteomic depth, and data reproducibility remains challenge. We report versatile,...
Bromodomains are acetyl-lysine specific protein interaction domains that have recently emerged as a new target class for the development of inhibitors modulate gene transcription. The two closely related bromodomain containing proteins BAZ2A and BAZ2B constitute central scaffolding nucleolar remodeling complex (NoRC) regulates expression noncoding RNAs. However, BAZ2 bromodomains low predicted druggability so far no selective been published. Here we report GSK2801, potent, cell active...
The novel coronavirus disease 2019 (COVID-19) has spread globally and the meteorological factors vary greatly across world. Understanding effect of control strategies on COVID-19 transmission is critical to contain epidemic. Using individual-level data in mainland China, Hong Kong, Singapore, number confirmed cases other regions, we explore temperature, relative humidity, measures COVID-19. We find that high temperature mitigates disease. High humidity promotes when low, but tends reduce...
Our study indicates high efficiency of mNGS using BALF for the detection causative pathogens that cause pneumonia in children. can be a potential diagnostic tool to supplement conventional methods children’s pneumonia.
Nasopharyngeal carcinoma (NPC) is a malignancy with high metastatic and invasive nature.Distant metastasis contributes substantially to treatment failure mortality in NPC.Platelets are versatile blood cells the number of platelets positively associated distant tumor cells.However, role underlying mechanism responsible for NPC remain unclear.Here we found that patients was correlated expression levels integrin β3 (ITGB3) platelet-derived extracellular vesicles (EVs) from (P-EVs).We further...
Abstract Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose beads for the comprehensive enrichment endogenously expressed protein kinases from cell lines and tissues. These enable chemoproteomics profiling interest in dose-dependent competition studies combination with quantitative mass spectrometry. We present improved bead matrices that capture more than 350 15 lipid human lysates, respectively. A multiplexing strategy is suggested enables determination apparent...
Abstract Aims The activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in endothelial cells (ECs) contributes to vascular inflammation atherosclerosis. Considering the high glycolytic rate ECs, we delineated whether and how glycolysis determines NLRP3 Methods results Our demonstrated a significant up-regulation 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB3), key regulator glycolysis, human mouse atherosclerotic endothelium, which...
Four nonlinear optical chromophores <bold>A–D</bold> functionalized with different isolation groups on both the donor and bridge sections of have been synthesized systematically investigated.
Heat shock protein 90 (HSP90) is an important glucocorticoid receptor (GR) chaperone protein, and supposed to be the key factor in regulating glucocorticoids (GCs) effects. The aim of present study was explore whether single nucleotide polymorphisms (SNPs) within HSP90AA1 gene affect response systemic lupus erythematosus (SLE) patients GCs treatment. Two hundred forty-five SLE were treated with (prednisone) for 12 weeks. disease activity index (SLEDAI) used assess treatment, classified into...
Endothelial dysfunction plays a crucial role in aortic remodeling. Aerobic glycolysis and endothelial-to-mesenchymal transition (EndoMT) have, respectively, been suggested to contribute endothelial many cardiovascular diseases. Here, we tested the hypothesis that glycolytic reprogramming is critical for EndoMT induction remodeling through an epigenetic mechanism mediated by transcriptional corepressor CtBP1 (C-terminal binding protein 1), sensor of glycolysis-derived NADH.EndoMT program,...
This paper analyzed the causes of peripheral nerve injury induced by acupoint injection, and proposed methods for prevention. These included emphasizing physicochemical properties medications strengthening research on medication compatibility, classifying high-risk acupoints establishing international standards safe needling, standardizing clinical procedures incorporating ultrasound technology when necessary to improve accuracy safety procedure. strategies aimed reduce risk associated with...
Abstract mMDSCs (monocytic myeloid derived suppressor cells) are recruited to solid tumors and serve as potent inhibitors of T-cell mediated antitumor immunity. Therapeutic depletion presents an exciting opportunity increase the frequency durability anti-tumor clinical responses achieved with immune checkpoint inhibition. Currently, no marketed or investigational agents function by specific mMDSC markers for therapeutic targeting these cells have been clinically validated. We demonstrate...
Abstract Background To evaluate trends in the in-hospital mortality rate for pediatric cardiac surgery procedures between 2005 and 2017 our center, to discuss characteristics of children’s CHD after thoracotomy. Methods This retrospective data were collected from medical records children underwent 2017. Results A total 19,114 with 444 died, was 2.3%. Complex mixed defect had highest fatality (8.63%), left obstructive lesion second (4.49%), right shunt third (3.51%), lowest (χ2 = 520.3, P...
Background Sebaceous carcinoma represents a rare and potentially fatal adnexal malignancy. Poorly‐differentiated sebaceous consisting of infiltrative basaloid tumor cells with inapparent lipid vesicles can mimic basal cell (BCC). Conversely, other epithelial tumors exhibit clear histopathology carcinoma. At the present time, immunohistochemical markers unique for are limited. Methods We evaluated expression three synthesis/processing protein alpha/beta hydrolase domain‐containing 5 ( ABHD5...
Abstract Purpose [ 18 F]-FDG PET/CT and brain MRI are common approaches to detect metastasis in patients of lung cancer. Current guidelines for the use clinical T1-category cancer lack risk-based stratification require optimization. This study stratified based on metastatic risk terms lesions' size morphological characteristics. Methods The detection rate was measured different sizes characteristics (solid sub-solid) tumors. To confirm cut-off value discriminating overall survival (OS)...
Abstract Identifying pharmacological probes for human proteins represents a key opportunity to accelerate the discovery of new therapeutics. High-content screening approaches expand ligandable proteome offer potential expedite novel chemical study protein function. Screening libraries reactive fragments by chemoproteomics offers compelling approach ligand discovery, however, optimising sample throughput, proteomic depth, and data reproducibility remains challenge. We report versatile,...
Limited research exists on screening thresholds for low-dose CT in detecting malignant pure ground-glass lung nodules (pGGNs) the Chinese population. A retrospective analysis of Guangzhou Lung-Care programme was conducted, retrieving average transverse diameter, location, histopathology, frequency and follow-up intervals. Diagnostic performances 'lung cancers' were evaluated using areas under curve (AUCs), decision (DCA), sensitivities specificities, with ranging from 5 mm to 10 mm. We...
The aim of our study was to assess the associations HSP90AB1 copy number variations (CNVs) with systemic lupus erythematosus (SLE) risk and glucocorticoids (GCs) efficacy, as well relationship between single-nucleotide polymorphisms (SNPs) GCs efficacy. CNVs SLE were analysed in 519 patients 538 controls. Patients treated followed up for 12 weeks divided into sensitive insensitive groups investigate effects (419 patients) SNPs (457 on efficacy GCs. Health-related quality life (HRQoL) also...