A5012327060- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bioactive natural compounds
- MicroRNA in disease regulation
- Heavy metals in environment
- Estrogen and related hormone effects
- Sirtuins and Resveratrol in Medicine
- Advanced Nanomaterials in Catalysis
- Histone Deacetylase Inhibitors Research
- Bone Tissue Engineering Materials
- Connexins and lens biology
- Nitric Oxide and Endothelin Effects
- Musculoskeletal pain and rehabilitation
- Traditional Chinese Medicine Analysis
- Cancer Cells and Metastasis
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Geochemistry and Geologic Mapping
- Cardiac Ischemia and Reperfusion
- Mine drainage and remediation techniques
- Cancer Mechanisms and Therapy
- Garlic and Onion Studies
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
Nanchang University
2011-2025
Gannan Medical University
2021-2025
Guangdong University of Technology
2022-2025
First Affiliated Hospital of Gannan Medical University
2025
Jiangxi Provincial Academy of Medical Sciences
2016-2025
Southern Medical University
2022-2025
State Key Laboratory of Respiratory Disease
2023-2024
Guangzhou Medical University
2023-2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
Recent advances in bioprinting have granted tissue engineers the ability to assemble biomaterials, cells, and signaling molecules into anatomically relevant functional tissues or organ parts. Scaffold-free fabrication has recently attracted a great deal of interest due recapitulate biology by using self-assembly, which mimics embryonic development process. Despite several attempts, scale-up at clinically-relevant dimensions with closely recapitulated functionality is still major roadblock....
Abstract Metastasis remains the principal cause of cancer-related lethality despite advancements in cancer treatment. Dysfunctional epigenetic alterations are crucial metastatic cascade. Among these, super-enhancers (SEs), emerging as new regulators, consist large clusters regulatory elements that drive high-level expression genes essential for oncogenic process, upon which cells develop a profound dependency. These SE-driven oncogenes play an important role regulating various facets...
Chronic stress is generally known to exacerbate the development of numerous neuropsychiatric diseases such as fear and anxiety disorders, which at least partially due disinhibition amygdala subsequent prolonged exposure. GABA receptor A (GABAAR) mediates primary component inhibition in brain its activation produces two forms inhibition: phasic tonic inhibition. While both them are critically engaged limiting activity amygdala, their roles chronic exposure largely unknown. We investigated...
ABSTRACT Bisphenol A (BPA), one of the most common environmental endocrine disruptors, has been recognized to have wide adverse effects on brain development and behavior. These adversities are related its ability bind estrogen receptor (ER) with subsequent alteration expression in target areas. However, very little is known about whether BPA exposure also affects ER phosphorylation translocation nucleus during postnatal development, two critical steps for function. Here, we found that from...
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), induce high morbidity mortality rates, which challenge the present approaches for treatment of ALI/ARDS. The clinically used photosensitizer verteporfin (VER) exhibits great potential in (ALI/ARDS) by regulating macrophage polarization reducing inflammation. Nevertheless, hydrophobic characteristics, nonspecificity, constrained bioavailability hinder therapeutic efficacy. In this work, we developed a...
Histone deacetylase 3 (HDAC3) is a well-established target for cancer therapy. Herein, we developed LSQ-28 as novel HDAC3 inhibitor, which exhibited high inhibitory activity (IC50 = 42 nM, SI > 161) and displayed potent antiproliferative against four cells further demonstrated excellent antimigratory, anti-invasive, antiwound healing activities. Further studies revealed that induced dose-dependent increase in Ac-H3 expression promoted the degradation of PD-L1. Additionally, enhanced DNA...
This paper analyzed the causes of peripheral nerve injury induced by acupoint injection, and proposed methods for prevention. These included emphasizing physicochemical properties medications strengthening research on medication compatibility, classifying high-risk acupoints establishing international standards safe needling, standardizing clinical procedures incorporating ultrasound technology when necessary to improve accuracy safety procedure. strategies aimed reduce risk associated with...