A5101797648- Immune cells in cancer
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Lymphoma Diagnosis and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Viral-associated cancers and disorders
- Pancreatic and Hepatic Oncology Research
- Metabolomics and Mass Spectrometry Studies
- Neuroblastoma Research and Treatments
- Esophageal Cancer Research and Treatment
- Pituitary Gland Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Research and Treatments
- Neuroendocrine Tumor Research Advances
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- Respiratory Support and Mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2015-2025
Macau University of Science and Technology
2024-2025
Xihua University
2025
Shanxi Medical University
2024
Peking University
2015-2024
Southern Medical University
2015
University of Chicago
1998
Background: In cancer immunotherapy, gene therapy has become a promising strategy through the introduction of immunostimulatory components into its formulation. However, ideal non-viral delivery platforms capable simultaneously maintaining high efficiency and immune activation are still in demand. As an intestinal probiotic, Lactobacillus reuteri potential correlation with progression. Its unique antigenicity also confers immunomodulatory activity. Method: We engineered new siRNA system,...
The aberrant expression of microRNAs has been demonstrated to play a crucial role in the initiation and progression hepatocarcinoma. miR-1246 High invasive ability cell line than significantly higher that low line. Transwell chambers (8-uM pore size; Costar) were used vitro migration invison anssay. Dual luciferase reporter gene construct assay identify target miR-1246. CADM1 was evaluated by immunohistochemistric staining. clinical manifestations, treatments survival collected for...
Metastasis is one of the hallmarks cancer malignancy that usually causes more detrimental effects than a primary tumor. Many microRNAs were reported to be involved in process tumor metastasis. Hep11 and Hep12 cells derived from recurrence (intrahepatic metastatic) sites hepatocellular carcinoma (HCC), respectively. exhibited higher invasive migratory potential Hep11. There was also significantly expression miR‐9 cells. Further studies HCC cell lines demonstrated could promote migration...
The objective of this study was to predict the value lymphocyte subsets in cancer progression. Peripheral blood obtained from 327 untreated patients with and 158 healthy volunteers. Levels were determined by flow cytometry. There decreased levels natural killer (NK) cells, CD8+ T naïve CD4+ /CD4+ cells compared those controls. Inversely, there elevated following T-cell percentages controls: memory , HLA-DR/CD8+ CD38+ /CD8+ . In addition, are a decreasing trend terms counts an increase...
Background Programmed cell death protein-1/programmed ligand-1 (PD-1/PD-L1) inhibitors works by reactivating immune cells. Considering the accessibility of noninvasive liquid biopsies, it is advisable to employ peripheral blood lymphocyte subsets predict immunotherapy outcomes. Methods We retrospectively enrolled 87 patients with available baseline circulating subset data who received first-line PD-1/PD-L1 at Peking Union Medical College Hospital between May 2018 and April 2022. Immune...
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), induce high morbidity mortality rates, which challenge the present approaches for treatment of ALI/ARDS. The clinically used photosensitizer verteporfin (VER) exhibits great potential in (ALI/ARDS) by regulating macrophage polarization reducing inflammation. Nevertheless, hydrophobic characteristics, nonspecificity, constrained bioavailability hinder therapeutic efficacy. In this work, we developed a...
// Chun-Ting Hu 1, 2 , Li-Li Guo Na Feng Lei Zhang 3 Zhou 1 Ma Lan Shen Gui-Hui Tong Qian-Wen Yan Shi-Jie Zhu Xiu-Wu Bian 4 Mao-De Lai 5 Yong-Jian Deng Yan-Qing Ding Department of Pathology, Nanfang Hospital and School Basic Medical Sciences, Southern University, Guangzhou 510515, China Guangdong Provincial Key Laboratory Molecular Tumor General Surgery, Renji Hospital, Shanghai Jiaotong University Medicine, 200127, Southwest Third Military Chongqing 400038, Zhejiang Hangzhou 310006,...
Tumor-associated macrophages (TAMs) have been found to be associated with the progression and metastasis of breast cancer. To clarify mechanisms underlying crosstalk between TAMs cancer stem cells (CSCs) in recurrence metastasis, we used a co-culture model apoptotic human cell line MCF-7 investigate effects on vitro vivo. Macrophages co-cultured had increased tumor growth metastatic ability nude mouse transplantation assay. The exposed also induce an increase proportion CD44+/CD24− stem-like...
Metabolic regulators can improve the athletic ability of athletes by regulating body metabolism, but it is not conducive to fair competition, so listed as a prohibited substance. At same time, State General Administration Sport ordered major event organizers test food for food-borne stimulants. Surface-enhanced Raman scattering (SERS) spectroscopy has been widely used because its excellent sensitivity and strong spectral characteristics. Based on available information, SERS spectrum data...
// Yizhuang Zhang 1, * , Na Zhou Xiuyan Yu Xuehui 1 Shanxin Li Zhen Lei 5 Ruobi Hu Hui Yiqing Mao Xi Wang Jinshu 2 Yuan 3 Hongyan Guo David M. Irwin 4 Gang Niu and Huanran Tan Department of Pharmacology, Peking University, Beijing, China Clinical Laboratory, The 305 Hospital People’s Liberation Army, Gynaecology Obstetrics, University Third Hospital, Laboratory Medicine Pathobiology, Toronto, Canada N & Genetech Company, Ltd., These authors have contributed equally to this work...
Objective: The identification of DNA polymerase epsilon (POLE) mutation subtypes in endometrial cancer is critical for molecular classification. the POLE gene could only be detected by sequencing until now. We propose to validate and develop feasibility using BaseScope, an situ hybridization (ISH) assay, detection mutations high-grade endometrioid carcinomas (EC). Methods: Among 51 paraffin-embedded samples EC, BaseScope-ISH assays were used detect RNA status gene, mainly focusing on two...
Abstract Lung adenocarcinoma (LUAD) is the most common histological subtype in non-small cell lung cancer, which malignant tumor with highest mortality and morbidity world. Herein, ZNF280A, a member of zinc finger protein family carrying two consecutive Cys2His2 domains, was shown by us to act as driver LUAD. The immunohistochemical analysis ZNF280A LUAD indicated its positive correlation grade, pathological stage lymphatic metastasis, negative relationship patients’ survival. A...
Abstract Background Treatment for non-small cell lung cancer (NSCLC) has greatly improved in recent years. However, noninvasive early screening carcinogenesis and progression unclear. The aim of this study was to explore the predictive value peripheral blood immune cells untreated NSCLC patients. Methods We retrospectively enrolled 305 patients 132 healthy participants from February 2016 August 2019 Peking Union Medical College Hospital. Immune levels were determined by flow cytometry...
Tumor metastasis is a key factor affecting the life of patients with malignant tumors.For past hundred years, scientists have focused on how to kill cancer cells and inhibit their in vivo, but few breakthroughs been made.Here we hypothesized novel mode for metastasis.We show that phagocytosis apoptotic tumor by macrophages leads polarization into M2 phenotype, expression stem cell related as well drug resistance genes was induced.Therefore, it appears "defected" transformed initial...
Background Pulmonary lymphoepithelioma-like carcinoma (LELC) exhibits a unique immune microenvironment, including high PD-L1 expression and abundant infiltrating-immune cells. However, the availability of PD-1/PD-L1 inhibitors in patients with LELC is still not determined. Methods A total 36 cases pulmonary treated were reviewed, 10 from our institute 26 included literature. The Kaplan-Meier method log-rank test utilized to analyze survival outcomes receiving immunotherapy, factors related...
MicroRNAs are predicted to play fundamental roles in the tumorigenesis of hepatocellular carcinoma (HCC). MiR-375 is frequently downregulated HCC and acts as a tumor suppressor by targeting multiple oncogenes. The objective this study was evaluate miR-375 expression its relevance prognosis HCC. measured cancerous tissues using qRT-PCR dichotomized based on median cutoff. association between clinicopathological parameters subsequently determined. Expression levels were detected cohort 38...
The aim of the present study was to assess effect Endostar and temozolomide or dacarbazine plus 5-fluorouracil (5-FU) in patients with advanced pancreatic neuroendocrine tumors (pNETs).Phase II 14 locally metastatic well-differentiated pNETs treated between April 2013 September 2016. Patients received 5-FU, Endostar. primary outcome radiographic response rate.All had nonfunctional pNETs. Six 8 + combined Thirteen were assessable for treatment response: 1(7%) complete response, 5 (39%)...
Objective: To investigate the effects of gastrodin, astragaloside and paeoniflorin from three types traditional Chinese herbs against on β-amyloid plaques memory ability in 5XFAD Alzheimer's disease (AD) transgenic mice. Methods: Seventy mice were randomly divided into seven groups, namely gastrodin-high gastrodin-low dose groups (GAS-H, GAS-L), astragaloside-high astragaloside-low (AST-H, AST-L), paeoniflorin-high paeoniflorin-low (PAE-H, PAE-L), positive control group. Negative also...