A5100360416- Hate Speech and Cyberbullying Detection
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Artificial Intelligence in Healthcare and Education
- Explainable Artificial Intelligence (XAI)
- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- Developmental Biology and Gene Regulation
- Extracellular vesicles in disease
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- CAR-T cell therapy research
- Hedgehog Signaling Pathway Studies
- Immune cells in cancer
- Immune Cell Function and Interaction
- Topic Modeling
- Circular RNAs in diseases
- PI3K/AKT/mTOR signaling in cancer
- AI in Service Interactions
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- PARP inhibition in cancer therapy
- Magnesium Oxide Properties and Applications
Shenzhen Third People’s Hospital
2021-2025
Southern University of Science and Technology
2021-2025
Murray State University
2024-2025
National Clinical Research
2022-2025
Chinese University of Hong Kong, Shenzhen
2025
Indiana University School of Medicine
2025
Chinese University of Hong Kong
2025
University of Georgia
2024
Auburn University
2023-2024
Shuguang Hospital
2023-2024
The treatment and prevention of pathogenic diseases by lactic acid bacteria (LAB) has attracted more attention. As a special LAB,
Abstract Development of potent and broad‐spectrum drugs against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) remains one the top priorities, especially in cases emergence mutant viruses inability current vaccines to prevent viral transmission. In this study, we have generated a novel membrane fusion‐inhibitory lipopeptide IPB29, which is currently under clinical trials; herein, report its design strategy preclinical data. First, surprisingly found that IPB29 with rigid linker...
Abstract Aim Long noncoding RNAs (lncRNAs) are key mediators with a wide range of pathophysiological functions, but their role in human hepatocellular carcinoma (HCC) is still unclear. Methods An unbiased microarray study evaluated novel lncRNA, HClnc1, that linked to the development HCC. In vitro cell proliferation assays and an vivo xenotransplanted HCC tumor model were performed determine its followed by antisense oligo‐coupled mass spectrometry identify HClnc1‐interacting proteins. To...
We have previously established a clade Ⅱb mpox virus (MPXV) pathogenic BALB/c mouse model for developing countermeasures. Here, we comprehensively investigated the susceptibility of and C57BL/6 mice to MPXV found that Clade IIb was capable rapid replication in lungs both strains, thus triggering similar dynamic pathological changes antibody responses. However, mice, compared seem less susceptible MPXV, evidenced by no significant weight loss, lower viral load, faster clearance, earlier...
Abstract Robust control of DNA replication is fundamental to bacterial proliferation. In Escherichia coli , initiation thought be regulated by oscillations in DnaA activity, driven DnaA-chromosome interactions that differ among leading models. However, direct evidence linking these has been lacking, and existing models fail explain the observed decoupling from dnaA expression. Here, we establish a link between activity demonstrating robust which peak precisely at across diverse growth...
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge and spread around the world, antibodies vaccines confer broad potent neutralizing activity are urgently needed. Through isolation characterization of monoclonal (mAbs) from individuals infected with SARS-CoV-2, we identified one antibody, P36-5D2, capable major SARS-CoV-2 concern. Crystal electron cryo-microscopy (cryo-EM) structure analyses revealed that P36-5D2 targeted a conserved epitope on...
Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent and durable effects in B-cell malignancies. However, loss or downregulation is a frequent cause of resistance. Here, we report development novel CAR T-cell therapy product to target CD79b, pan antigen, widely expressed most lymphomas.
This article is a Commentary on Hu et al . (2024), 242 : 333–343
Abstract Exercise-induced mechanical loading can increase bone strength whilst unloading enhances bone-loss. Here, we investigated the role of lncRNA NONMMUT004552.2 in unloading-induced Knockout hindlimb-unloaded mice caused an formation and osteoblast activity. The silencing also decreased apoptosis expression Bax cleaved caspase-3, increased Bcl-2 protein MC3T3-E1 cells. Mechanistic investigations demonstrated that functions as a competing endogenous RNA (ceRNA) to facilitate spectrin...
Jasmonate ZIM-domain family proteins (JAZs) are repressors in the signaling cascades triggered by jasmonates (JAs). It has been proposed that JAs play essential roles sesquiterpene induction and agarwood formation processes Aquilaria sinensis. However, specific of JAZs A. sinensis remain elusive. This study employed various methods, including phylogenetic analysis, real-time quantitative PCR, transcriptomic sequencing, yeast two-hybrid assay, pull-down to characterize JAZ members explore...
spp., a class of aerobic bacteria, is widely used as biocontrol microbe in the world. However, reactive oxygen species (ROS) will accumulate once bacteria are exposed to environmental stresses, which can decrease cell activity or lead death. Hydroxyl radical (·OH), strongest oxide ROS, damage DNA directly, generated through Fenton Reaction by H
Tumor metastasis is a key factor affecting the life of patients with malignant tumors.For past hundred years, scientists have focused on how to kill cancer cells and inhibit their in vivo, but few breakthroughs been made.Here we hypothesized novel mode for metastasis.We show that phagocytosis apoptotic tumor by macrophages leads polarization into M2 phenotype, expression stem cell related as well drug resistance genes was induced.Therefore, it appears "defected" transformed initial...
It is poorly understood what cellular types participate in ductular reaction (DR) and whether DR facilitates recovery from injury or accelerates hepatic fibrosis. The aim of this study to gain insights into the role progenitor cell (HPC)-originated during fibrotic progression.
ABSTRACT Vertebrates and tunicates are sister groups that share a common fusogenic factor, Myomaker (Mymk), drives myoblast fusion muscle multinucleation. Yet they divergent in when where express Mymk. In vertebrates, all developing skeletal muscles Mymk obligately multinucleated. tunicates, is expressed only post-metamorphic multinucleated muscles, but absent from mononucleated larval muscles. this study, we demonstrate cis-regulatory sequence differences the promoter region of underlie...
To identify novel susceptibility genes for hepatocellular carcinoma (HCC), we performed a rare-variant association study in Chinese populations consisting of 2,750 cases and 4,153 controls. We identified four HCC-associated genes, including NRDE2, RANBP17, RTEL1, STEAP3. Using NRDE2 (index rs199890497 [p.N377I], p = 1.19 × 10−9) as an exemplary candidate, demonstrated that it promotes homologous recombination (HR) repair suppresses HCC. Mechanistically, binds to the subunits casein kinase 2...
Hepatic fibrosis is the pivotal determinant in progression of chronic liver diseases towards cirrhosis or advanced stages. Studies have shown that Schisantherin A (Sin A), primary active compound from Schizandra chinensis (Turcz.) Baill., exhibits anti-hepatic effects. However, mechanism Sin remain unclear.
ABSTRACTThe present work investigates the performance of a biofilm reactor filled with new type combined packing used to treat wastewater and explores technology approach for application coral sand waste non-woven fabric. The was made fabric, which as carrier sewage. experimental results showed that removal efficiencies COD, NH4+-N TN in containing were 92.9%, 72.9% 63.2%, respectively. maximum single 89.0%, 63.4% 55.2%, properties characterized by Fourier Transform Infrared (FTIR), specific...
The aim of this study is to construct an artificial neural network (ANN) based on bioinformatic analysis enable early diagnosis peri-implantitis (PI). PI-related datasets were retrieved from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) and functional enrichment analyses performed between PI control group. Furthermore, infiltration 22 immune cells in was analyzed using CIBERSORT. Hub identified with random forest (RF) classification. ANN model then constructed...