A5006799211- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- interferon and immune responses
- Kruppel-like factors research
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Fibroblast Growth Factor Research
- Lung Cancer Treatments and Mutations
- Hippo pathway signaling and YAP/TAZ
- Protein Tyrosine Phosphatases
- Corneal Surgery and Treatments
Lanzhou University
2021-2025
First Hospital of Lanzhou University
2021-2025
ShenZhen People’s Hospital
2019-2024
Chongqing Medical University
2021-2023
Wuhan University
2018-2022
Renmin Hospital of Wuhan University
2018-2022
Jinan University
2020-2022
Third People 's Hospital of Chongqing
2022
Hangzhou Medical College
2018-2021
Zhejiang Provincial People's Hospital
2018-2021
To help health workers and the public recognize deal with 2019 novel coronavirus (2019-nCoV) quickly, effectively, calmly an updated understanding. A comprehensive search from Chinese worldwide official websites announcements was performed between 1 December 9:30 am 26 January 2020 (Beijing time). latest summary of 2019-nCoV current outbreak drawn. Up to 24 pm, 25 2020, a total 1975 cases infection were confirmed in mainland China 56 deaths having occurred. The mortality approximately 2.84%...
Long noncoding RNAs (lncRNAs) play important roles in regulating the development and progression of many cancers. However, clinical significance specific lncRNAs context nasopharyngeal carcinoma (NPC) molecular mechanisms by which they regulate this form cancer remain largely unclear. In study we found that lncRNA PVT1 was upregulated NPC, patients upregulation associated with reduced survival. RNA sequencing revealed responsible for NPC cell proliferation controlling a hypoxia-related...
Abstract Aberrant amplification and mutations of epidermal growth factor receptor (EGFR) are the most common oncogenic events in glioblastoma (GBM), but mechanisms by which they promote aggressive pathogenesis not well understood. Here, we determine that non-canonical histone signature acetylated H3 lysine 23 (H3K23ac)-binding protein tripartite motif-containing 24 (TRIM24) is upregulated clinical GBM specimens required for EGFR-driven tumorigenesis. In multiple glioma cell lines...
Ferroptosis is a form of cell death characterized by non-apoptosis induced small molecules in tumors. Studies have demonstrated that ferroptosis regulates the biological behaviors Therefore, genes control can be promising candidate bioindicator tumor therapy. Herein, functions ferroptosis-related glioma were investigated. We systematically assessed relationship between expression profiles and prognosis patients based on The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) RNA sequencing...
Smad nuclear-interacting protein 1 (SNIP1) is a transcription repressor related to the TGF-β signaling pathway and associates with c-MYC, key regulator of cell proliferation tumor development. Currently, mechanism by which SNIP1 regulates tumorigenesis cancer metastasis unknown. Here, we identify that non-histone substrate lysine methyltransferase KMT5A, undergoes KMT5A-mediated mono-methylation promote breast growth, invasion lung metastasis. Mechanistically, show K301 methylation...
Annexin A2 (ANXA2) is a widely reported oncogene. However, the mechanism of ANXA2 in esophageal cancer not fully understood. In this study, we provided evidence that promotes progression squamous cell carcinoma (ESCC) through downstream target threonine tyrosine kinase (TTK). These results are consistent with up-regulation and TTK ESCC. vitro experiments by knockdown overexpression revealed ESCC enhancing proliferation, migration, invasion. Subsequently, animal models also confirmed role...
Abstact Conventional therapies and novel molecular targeted against breast cancer have gained great advances over the past two decades. However, poor prognosis low survival rate are far from expectation for improvement, particularly in patients with triple negative (TNBC). Here, we found that lncRNA DANCR was significantly overregulated TNBC tissues cell lines compared normal or other type of cancer. Knockdown suppressed proliferation both vitro vivo. Further study underlying mechanisms...
This study aimed to elucidate how miR-27a-3p modulates the Wnt/β-catenin signaling pathway promote colorectal cancer (CRC) progression. Our results showed that expression of was up-regulated in CRC and closely associated with histological differentiation, clinical stage, distant metastasis patients' survival. mimic suppressed apoptosis promoted proliferation, migration, invasion cells vitro vivo. Whereas inhibitor Furthermore, RXRα target gene CRC. negatively correlated tissues. The...
Aberrant EGFR signaling is a common driver of glioblastoma (GBM) pathogenesis; however, the downstream effectors that sustain this oncogenic pathway remain unclarified. Here we demonstrate tripartite motif-containing protein 59 (TRIM59) acts as new effector by regulating STAT3 activation in GBM. led to TRIM59 upregulation through SOX9 and enhanced interaction between nuclear STAT3, which prevents dephosphorylation form T-cell tyrosine phosphatase (TC45), thereby maintaining transcriptional...
Objective. Ferroptosis is an iron- and ROS-dependent form of cell death initiated by lipid peroxidation. The rapidly developing study ferroptosis has facilitated its application in cancer therapeutics. current aimed at investigating the functional property ferulic acid (FA, a phenolic substance) on inducing antiesophageal squamous carcinoma (ESCC). Methods. ESCC cells were administrated with gradient doses FA or inhibitor deferoxamine. Cellular growth was measured CCK-8 colony formation...
SOX2 is a transcription factor that contributes to modification and cancer, but the mechanism by which regulates nasopharyngeal carcinoma cell proliferation not well understood. Here, we identify signaling pathway facilitates carcinoma, where it upregulated. expression was associated with patient survival. knockdown inhibited proliferation, colony formation, tumorigenesis in an subcutaneous mouse xenograft model system. Six hundred ninety-nine candidate downstream dysregulated genes were...
Abstract Recent molecularly targeted approaches have gained advances in nasopharyngeal carcinoma treatment. However, the estimated five-year survival rate has not met desired degree of improvement. Here, we report that upregulation expression SOX2-activated lncRNA ANRIL is involved carcinoma. been found to be upregulated clinical Using genetic targeting cells, knockdown inhibits cell proliferation vitro and vivo . Mechanistically, SOX2 binds with increases its RNA level, which upregulates...
Despite radiotherapy being one of the major treatments for triple-negative breast cancer (TNBC), new molecular targets its treatment are still required due to radioresistance. CDK2 plays a critical role in TNBC. However, mechanism by which promotes TNBC radioresistance remains be clearly elucidated. We aimed elucidate relationship between and TRIM32 regulation performed immunohistochemical staining detect nuclear TRIM32, STAT3 on tissues. Western blot assays PCR were used protein mRNA level...
Ovarian cancer (OC) is estimated to kill ~14,000 women in the United States 2019.Current chemotherapies treat OC initially show therapeutic efficacy but frequently drug resistance develops, at which point therapies with alternative targets are needed.Herein, we describing a novel approach sensitize these tumors standard by increasing transcription of hypoxia-inducible factor antisense.Methods: Genome-wide Bru-seq analysis was performed fully capture nascent transcriptional signature cells...
Abstract A notable number of locally advanced cervical carcinoma (LACC) patients experience local or distant disease relapse following radiotherapy. The contribution tumor microenvironment (TME) to recurrence at different sites remains unclear. Here, single‐nucleus RNA sequencing data from 28 pre‐ and on‐treatment LACC samples with patterns is analyzed. findings revealed opposing alterations in the expression levels cellular senescence pathway after radiotherapy relapses. In contrast, an...
Metastasis is the most common cause of death in ovarian cancer patients but remains largely untreated. Epithelial‑mesenchymal transition (EMT) critical for conversion early‑stage tumors into metastatic malignancies. Thus, investigating signaling pathways promoting EMT may identify potential targets treatment cancer. Lysine demethylase 2A (KDM2A), also known as FBXL11 and JHDM1A, a histone H3 lysine 36 (H3K36) that regulates metastasis However, function underlying mechanisms suppression have...
Introduction. Lung cancer is the most common malignant tumor and main cause of tumor-related death globally. As 5-year survival rate lung adenocarcinoma (LUAD) remains low, it necessary to investigate novel molecular markers therapeutic targets for LUAD. Materials Methods. The protein expression CD73 (NT5E) in LUAD specimens was analyzed using immunohistochemistry. Reverse transcription-quantitative PCR western blot analysis were used analyze mRNA levels several genes cells. proliferation...
STMN1 belongs to the stathmin gene family, it encodes a cytoplasmic phosphorylated protein, stathmin1, which is commonly observed in vertebrate cells. structural microtubule-associated protein (MAP) that binds microtubule dimers rather than microtubules, with each binding two and preventing their aggregation, leading instability. expression elevated number of malignancies, inhibition its can interfere tumor cell division. Its change division cells, thereby arresting growth G2/M phase....