A5101872559- Liver Disease Diagnosis and Treatment
- DNA and Nucleic Acid Chemistry
- Cosmology and Gravitation Theories
- Hemoglobinopathies and Related Disorders
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Black Holes and Theoretical Physics
- Iron Metabolism and Disorders
- Diet and metabolism studies
- Pulsars and Gravitational Waves Research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Chemical Synthesis and Analysis
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Gut microbiota and health
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
- Click Chemistry and Applications
- Cancer Mechanisms and Therapy
- Ecology and Vegetation Dynamics Studies
- interferon and immune responses
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
Huazhong University of Science and Technology
2018-2025
National Tsing Hua University
2025
Hangzhou Medical College
2023-2025
Zhejiang Provincial People's Hospital
2023-2025
Fudan University
2008-2024
First Affiliated Hospital of GuangXi Medical University
2016-2024
Guangxi Medical University
2010-2024
Union Hospital
2018-2024
The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
2024
Sichuan Agricultural University
2006-2024
Abstract UBE2O, an E2/E3 hybrid ubiquitin-protein ligase, has been implicated in the regulation of adipogenesis, erythroid differentiation, and tumor proliferation. However, its role cancer radioresistance remains completely unknown. Here, we uncover that UBE2O interacts targets Mxi1 for ubiquitination degradation at K46 residue. Furthermore, show genetical or pharmacological blockade impairs progression lung vitro vivo, these effects can be restored by inhibition. Moreover, demonstrate is...
A previous study demonstrated that low-density lipoprotein cholesterol (LDL-C) is associated with hepatocellular carcinoma (HCC); however, the causality between them has not been proven due to conflicting research results and interference of confounders. This utilized Mendelian randomization (MR) investigate causal relationship LDL-C HCC identify mediating factors.LDL-C, HCC, coronary artery disease (CAD) genome-wide association (GWAS) data were obtained from a public database. To causality,...
Gut microbiota dysbiosis is a prominent determinant that significantly contributes to the disruption of lipid metabolism. Consequently, it essential occurrence and development non-alcoholic fatty liver disease (NAFLD). Nevertheless, connection between diet symbiotic gut in progression NAFLD remains uncertain. The purpose this study was explore role supplementing commensal Bacteroides fragilis (B. fragilis) on metabolism, microbiota, metabolites high-fat (HFD)-fed mice, elucidating impact...
A hemicyanine fluorescent dye was generated by a diamine-catalyzed, DNA-templated, aldol-type condensation from nonfluorescent precursors. Studies of reaction rate and yield as function catalyst structure indicated the diamine operates in concerted mechanism on both components. Our findings expand scope reactions that can be performed DPC demonstrate de novo chemical synthesis labels coupled to biological recognition events homogeneous format with essentially no background.
We constrain the scalar field dark energy model with an inverse power-law potential, i.e., $V(\phi)\propto {\phi}^{-\alpha}$ ($\alpha>0$), from a set of recent cosmological observations by compiling updated sample Hubble parameter measurements including 30 independent data points. Our results show that constraining power $H(z)$ HST prior on $H_0$ is stronger than those SCP Union2 and Union2.1 compilations. A strong gravitational lensing systems also adopted to confine even though are not...
Rationale:Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc.However, clinical significances and underlying mechanisms by which Mxi1 regulated in lung cancer remain poorly understood.Methods: Mass spectrometry analysis immunoprecipitation assay were utilized to detect protein-protein interaction.The phosphorylation was evaluated vitro kinase assays.Poly-ubiquitination examined vivo ubiquitination assay.Lung cells...
Despite radiotherapy being one of the major treatments for triple-negative breast cancer (TNBC), new molecular targets its treatment are still required due to radioresistance. CDK2 plays a critical role in TNBC. However, mechanism by which promotes TNBC radioresistance remains be clearly elucidated. We aimed elucidate relationship between and TRIM32 regulation performed immunohistochemical staining detect nuclear TRIM32, STAT3 on tissues. Western blot assays PCR were used protein mRNA level...
Inhibin B (INHBB), a heterodimer of common α‐subunit and βB‐subunit, is glycoprotein belonging to the transforming growth factor‐β (TGF‐β) family. In this study, we observed INHBB expression was reduced in nasopharyngeal carcinoma (NPC) tissues compared non‐tumor epithelium tissues, associated with lymph node metastasis, stage disease, clinical progress. Positive NPC predicted better prognosis (overall survival, P = 0.038). However, molecular mechanisms have not been addressed NPC. We...
Urbanization accelerates habitat fragmentation and leads to the decline of biodiversity in cities. Urban greenway landscapes provide not only social functions but also important ecological services. In this study, taxonomic richness, abundance, diversity, distribution soil meso- microfauna were investigated three different urban assess their environmental quality. that had a richer tree species composition, higher deciduous ratios, wider greenspace, moderate temperature moisture, lower bulk...
Aim: This study aimed to evaluate the imbalance of erythropoiesis and iron metabolism in patients with thalassemia.Methods: 192 non-transfusion-dependent thalassemia (NTDT), 94 transfusion-dependent (TDT) 101 healthy controls were recruited between June 2013 December 2016 Hematology Department, First Affiliated Hospital Guangxi Medical University.The groups compared terms levels biomarkers [growth differentiation factor 15 (GDF15), erythropoietin (EPO) soluble transferrin receptor (sTfR)]...
Recently, over-expression of LAIR-1 has been found in some solid cancers, including ovarian cancer. The role cancer progression needs further investigation. In this study, we identified the cDNA sequence cells HO8910. Using SKOV3 cells, confirmed finding from our previous study that could suppress vitro cell proliferation and migration. We also overexpression can induce apoptosis cells. revealed suppressed growth by inhibiting PI3K-AKT-mTOR axis. Moreover, antitumor activity its mechanism...
Targeting adverse pathogenic gut microbiota regulation through fecal transplantation (FMT) may restore health and has been validated in some aging-related diseases. However, the mechanisms of microbiota's role frailty whether modulation can treat age-related remain largely unknown. To assess effects FMT on frailty, we used bidirectional young old mice. We demonstrated that bacteria transplanted from mice into reduced body weight grip strength (p=0.002), led to elevated inflammatory factors...
<title>Abstract</title> Background Cross-sectional evidence implicates sunlight exposure is associated with the risk of Parkinson's disease (PD), whereas from prospective studies scarce. Methods A cohort study based on UK Biobank enrolled participants between 2006 and 2010, latest follow-up in November 2022. In population-based 375,599 adults aged 37–73 years were enrolled. The outdoor light time was assessed using a questionnaire survey to investigate how many hours spent outdoors typical...
Abstract High‐entropy‐alloy (HEA) nanocrystals, characterized by multicomponent solid solutions and synergistic effects, hold great potential in catalysis. However, synthesizing HEA hollow nanocrystals with 3D architectures controlled surface atomic arrangements to enhance catalytic activity durability remains challenging. Highly active durable electrocatalysts are presented, derived from Pd@HEA core‐shell featuring a few layers containing five platinum‐group metals, synthesized via...