A5016221246- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Angiogenesis and VEGF in Cancer
- Advanced Cellulose Research Studies
- Regulation of Appetite and Obesity
- Cancer-related gene regulation
- Nutritional Studies and Diet
- MicroRNA in disease regulation
- Material Properties and Processing
- Pancreatic function and diabetes
- Peripheral Artery Disease Management
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Cerebrovascular and Carotid Artery Diseases
- Obesity, Physical Activity, Diet
- Neuropeptides and Animal Physiology
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Hormonal and reproductive studies
- Nitric Oxide and Endothelin Effects
Huazhong University of Science and Technology
2015-2025
Union Hospital
2015-2025
Wuhan Union Hospital
2015-2025
Guangxi Medical University
2025
Second Affiliated Hospital of Chengdu University of Traditional Chinese
2025
National Clinical Research Center for Digestive Diseases
2025
Massachusetts General Hospital
2015-2024
Harvard University
2015-2024
National Clinical Research
2024
South China University of Technology
2022-2024
Abstract Objective To estimate the global burden of type 2 diabetes in adolescents and young adults (aged 15-39 years) from 1990 to 2019. Design Systematic analysis. Data source Global Burden Disease Study Participants aged years 204 countries territories, 1990-2019. Main outcomes measures Age standardised incidence rate, age disability adjusted life (DALY) mortality rate for people 2019, proportional DALY attributable different risk factors. Results From significant increases were found...
// Yong Feng 1,2 , Jacson Shen 1 Yan Gao Yunfei Liao 1,3 Gregory Cote 4 Edwin Choy Ivan Chebib 5 Henry Mankin Francis Hornicek and Zhenfeng Duan Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School, Jackson, Boston, Massachusetts, USA 2 Union Hospital, Tongji College, Huazhong University Science Technology, Wuhan, China 3 Endocrine, Division Hematology Oncology, Pathology, Correspondence to: Duan, email: Keywords : PD-L1, TILs,...
Abstract The mechanisms underlying glucocorticoid (GC)-induced obesity are poorly understood. Macrophages the primary targets by which GCs exert pharmacological effects and perform critical functions in adipose tissue homeostasis. Here, we show that macrophages essential for GC-induced obesity. Dexamethasone (Dex) strongly induced Krüppel-like factor 9 ( Klf9 ) expression macrophages. Similar to Dex, lentivirus-mediated overexpression inhibits M1 M2a markers expression, causing macrophage...
Iron overload is closely associated with metabolic dysfunction. However, the role of iron in hypothalamus remains unclear. Here, we find that hypothalamic levels are increased, particularly agouti-related peptide (AgRP)-expressing neurons high-fat-diet-fed mice. Using pharmacological or genetic approaches, reduce AgRP by central deferoxamine administration transferrin receptor 1 (Tfrc) deletion, ameliorating diet-induced obesity and related Conversely, Tfrc-mediated leads to overeating...
Programmed cell death ligand 1 (PD-L1) is a transmembrane protein that expressed on tumor cells suppresses the T cell-mediated immune response. Therapies targeting PD-L1 pathway promote anti-tumor immunity and have shown promising results in some types of cancers. However, functional therapeutic roles osteosarcoma remain largely unknown. In this study, we found was lines tissue microarray patient tumors. Tissue immunohistochemistry analysis showed overall five-year survival rates patients...
Vascular endothelial dysfunction is an early marker of atherosclerosis seen in type 2 diabetes (T2DM). Circulating progenitor cell (EPC) involved the neovasculogenesis and maintenance vascular homeostasis, whose impairment may have important role pathogenesis diabetic vasculopathy. This study was performed to investigate relationship between function circulating EPC number T2DM. A total 46 newly diagnosed T2DM patients (DM group) 51 healthy subjects (NG were recruited. Metformin administered...
"Metabolic memory" is identified as a phenomenon that previous exposure to hyperglycemia results in the long-lasting deleterious effects on cardiovascular events. More and more researches show epigenetics plays an important role pathogenesis of metabolic memory. It remains unclear whether microRNA (miRNA) dysfunctions participate event. In this study, miRNA arrays human aortic endothelial cells were adopted seek miRNAs may be involved memory verified vivo vitro. Sixteen found differentially...
Hashimoto's thyroiditis, also known as chronic lymphocytic is a common autoimmune which mostly occurs in young and middle-aged women. It can be manifested hyperthyroidism the early stage; hypothyroidism may appear with progression of disease. Studies have shown that multiple factors such heredity, environment, autoimmunity are involved pathogenesis, but specific mechanism not clear. In our study, we tried to find key genes potential molecular mechanisms thyroiditis provide new ideas for...
Very high levels of high-density lipoprotein cholesterol (HDL-C) have been paradoxically linked to increased mortality risk. The present study aimed examine associations HDL-C and varied sizes the HDL particle (HDL-P) with risk stratified by hypertension.This prospective cohort included 429 792 participants (244 866 hypertension 184 926 without hypertension) from UK Biobank. During a median follow-up 12.7 years, 23 993 (9.8%) 8142 (4.4%) deaths occurred among individuals hypertension,...
Scope Among patients with diabetes, who have modified nutritional behavior and a higher risk of cardiovascular disease (CVD), the influence ultraprocessed foods (UPFs) on CVD remains unknown. The study aims to evaluate association between UPF intake among individuals type 2 diabetes (T2D) further examine potential biological pathways linking association. Methods results This includes 5405 participants T2D provided at least one 24‐h dietary recall from UK Biobank study. In fully adjusted...
Abstract Context The relationship between the consumption of different beverages and risk microvascular complications in individuals with type 2 diabetes (T2D) is unclear. Objective To investigate association individual beverage consumption, including artificially sweetened (ASBs), sugar-sweetened (SSBs), tea, coffee, natural juice, yogurt, adults T2D. Methods This cohort study included 6676 participants T2D who were free macrovascular at baseline UK Biobank. Cox proportional hazard models...
Gout is a local inflammatory disease caused by the deposition of monosodium urate (MSU) crystals in joints or adjacent tissues. When some gout occurs without hyperuricemia, its clinical symptoms and signs are not typical, diagnosis will be delayed, so there an urgent need to find new biomarker predict diagnose flare. Our research attempts key genes potential molecular mechanisms through bioinformatics analysis, collected general data blood biochemical samples patients with healthy, then...
Abstract The immune system is finely tuned to fight against infections, eradicate neoplasms, and prevent autoimmunity. Protein posttranslational modification (PTM) constitutes a molecular layer of regulation guarantee the proper intensity response. Herein, we report that UBC9-mediated protein SUMOylation plays an essential role in peripheral CD4 T-cell proliferation, but without perceptible impact on polarization. Both conventional (Tcon) regulatory (Treg) maintenance are differentially...