A5063385377- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Viral Infections and Vectors
- Circular RNAs in diseases
- HIV-related health complications and treatments
- Immunotherapy and Immune Responses
- Dysphagia Assessment and Management
- Pharmacological Effects of Natural Compounds
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- COVID-19 and Mental Health
- RNA Interference and Gene Delivery
- SARS-CoV-2 detection and testing
- RNA Research and Splicing
- Viral Infections and Outbreaks Research
- HIV/AIDS drug development and treatment
- Lysosomal Storage Disorders Research
- HIV/AIDS Research and Interventions
Wuhan University
2016-2025
Zhongnan Hospital of Wuhan University
2007-2025
Universität Hamburg
2025
Wuhan Institute of Virology
2017-2024
University of Chinese Academy of Sciences
2020-2024
Hunan Children's Hospital
2022-2024
Institute of Microbiology
2020-2024
Chinese Academy of Sciences
2020-2024
Hebei Medical University
2013-2023
Fourth Hospital of Hebei Medical University
2020-2023
Although the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in specimens has been widely used to diagnose disease 2019 (COVID-19), it is undeniable that serum SARS-CoV-2 nucleic acid (RNAemia) could be detected a fraction COVID-19 patients. However, not clear whether testing for RNAemia correlated with occurrence cytokine storms or specific class patients.This study enrolled 48 patients admitted General Hospital Central Theater Command, People's...
Abstract COVID-19 was declared a pandemic on March 11 by WHO, due to its great threat global public health. The coronavirus main protease (M pro , also called 3CLpro) is essential for processing and maturation of the viral polyprotein, therefore recognized as an attractive drug target. Here we show that clinically approved anti-HCV drug, Boceprevir, pre-clinical inhibitor against feline infectious peritonitis (corona) virus (FIPV), GC376, both efficaciously inhibit SARS-CoV-2 in Vero cells...
Abstract Background Although the SARS-CoV-2 viral load detection of respiratory specimen has been widely used for novel coronavirus disease (COVID-19) diagnosis, it is undeniable that serum nucleic acid (RNAaemia) could be detected in a fraction COVID-19 patients. However, not clear if incidence RNAaemia correlated with occurrence cytokine storm or specific class Methods This study enrolled 48 patients admitted to General Hospital Central Theater Command, PLA, designated hospital Wuhan,...
An outbreak of severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) epidemic spreads rapidly worldwide. SARS-CoV-2 infection caused mildly to seriously and fatally respiratory, enteric, cardiovascular, neurological diseases. In this study, we detected analyzed the main laboratory indicators related heart injury, creatine kinase isoenzyme-MB (CK-MB), myohemoglobin (MYO), cardiac troponin I (ultra-TnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), in 273 patients with...
A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people West Africa, resulting 10,000 deaths. Preliminary analyses of genome sequences 81 EBOV collected from to June Guinea and Sierra Leone suggest that the originated an independent transmission event its natural reservoir followed by sustained human-to-human infections. It been reported variation might have effect on efficacy sequence-based detection candidate therapeutics. However, only limited viral...
Background: There were over 49 thousand Coronavirus infected diseases-19(COVID-19) patients in Wuhan city, Hubei province, China, the center of epidemic disease. Over 5000 HIV/AIDS live Wuhan. No data on morbidity COVID-19 have been published to date. Methods: In this study, we investigated 1178 two central districts city. Whether they any clinical presentations and whether contacted confirmed inquired. The results for nucleic acid test (NAT) SARS-CoV-2 CT scan those with symptoms or contact...
Background/Aim: Periodontal diseases and edentulism remain a prevalent disabling oral health condition worldwide, with significant regional disparities. This study systematically evaluated the burden of periodontal disease at global, regional, national levels from 1990 to 2021, using Global Burden Disease (GBD) 2021 framework. Patients Methods: We analyzed trends in incidence, prevalence, years lived disability (YLD), exploring their associations socio-demographic index (SDI) other risk...
Dicer cleaves double-stranded RNAs (dsRNAs) or precursor microRNAs (pre-miRNAs) to yield ≈ 22-nt RNA duplexes. The pre-miRNA structure requirement for human activity is incompletely understood. By large-scale in vitro dicing assays and mutagenesis studies, we showed that most, although not all, of the 161 tested pre-miRNAs efficiently. stable association with Dicer, as examined by gel shift assays, appears important but sufficient cleavage. Human tolerates remarkable structural variation its...
Shortening of the 3' untranslated regions (3'UTR) mRNA is an important mechanism for oncogene activation. However, 3'UTR alteration events, their pathologic functions, and underlying mechanisms in human urothelial carcinoma bladder (UCB) are not clear. Here, we combine RNA sequencing, bioinformatics, clinical studies two independent cohorts patients with UCB to identify a novel RAC1 shorter isoform that frequently expressed critical tumorigenesis acquisition poor prognostic phenotype...
iNOS plays an important role in mediating inflammation. In this study, we found that iNOS-derived NO was increased 2.4-fold the serum samples of 101 patients infected with influenza A virus comparison 105 healthy individuals. A549 human lung epithelial cells, infection or stimulation poly(I:C)+IFN-gamma resulted mRNA and protein levels both IL-32 iNOS, subsequent release NO. Over-expression upregulated expression production. Knock down by IL-32-specific siRNA inhibition dsRNA-induced...
"Metabolic memory" is identified as a phenomenon that previous exposure to hyperglycemia results in the long-lasting deleterious effects on cardiovascular events. More and more researches show epigenetics plays an important role pathogenesis of metabolic memory. It remains unclear whether microRNA (miRNA) dysfunctions participate event. In this study, miRNA arrays human aortic endothelial cells were adopted seek miRNAs may be involved memory verified vivo vitro. Sixteen found differentially...
A TCM formula has played an important role in the treatment of COVID-19 China. However, mechanism action is still unclear.
Abstract: MircroRNA-212 (miR-212) is proposed as a novel tumor-related miRNA and has been found to be significantly deregulated in human cancers. In this study, the miR-212 expression was obviously downregulated hepatocellular carcinoma (HCC) tissues compared with adjacent nontumor tissues. Clinical association analysis indicated that low of prominently correlated poor prognostic features HCC, including high AFP level, large tumor size, Edmondson-Steiner grading, advanced...
Accumulating evidence suggests that lncRNAs are involved in almost all normal physiological processes and aberrant expression of may be the development diseases, including non‑small cell lung cancer (NSCLC). However, roles lncRNA‑TPTE pseudogene 1 (TPTEP1) underlying molecular mechanisms have remained elusive. In present study, significant downregulation TPTEP1 tumors compared with tissues from patients NSCLC was observed. Overexpression inhibited proliferation induced apoptosis cells. A...
Abstract Background Lymphocyte count ( LYM) of peripheral blood and some indices general biochemical analysis had diagnostic prognostic value for coronavirus disease 2019 (COVID‐19), the other remaining is rare. Methods A total 94 patients with COVID‐19 were enrolled at Renmin Hospital Wuhan University. According to severity COVID‐19, divided into three groups (moderate 49, severe 35, critical 10), 40 healthy cases in same period as controls. The cell was analyzed. Results Compared cases,...
Accumulating signs have found that long noncoding RNAs (lncRNAs) contribute to hepatocellular carcinoma (HCC). Here, we probed the effect and mechanism of lncRNA DARS-AS1 in HCC. The profiles Cytoskeleton associated protein 2 (CKAP2) 50 HCC tissues non-tumor were examined by real-time quantitative polymerase chain reaction (RT-qPCR). CKAP2 overexpression and/or knockdown cell models established. proliferation, apoptosis, invasion epithelial-mesenchymal transition (EMT) determined. CKAP2,...
It remains unclear whether the history of switching antiretroviral therapy (ART) regimens is a standalone risk factor for lipid deterioration in people living with HIV (PLWH). This study aims to explore relationship between ART regimen and profiles PLWH. retrospective analysis data from HIV-positive individuals aged 16-82, enrolled at Jinyintan Hospital Wuhan, China, January 2018 June 2022. We investigated potential link their profiles. Locally weighted scatter plot smoother (LOESS) curves...