A5110286913- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Neonatal and Maternal Infections
- Infections and bacterial resistance
- Immune cells in cancer
- MicroRNA in disease regulation
- Antibiotic Resistance in Bacteria
- Plant-based Medicinal Research
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Plant responses to water stress
- Vibrio bacteria research studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Paraoxonase enzyme and polymorphisms
- Yersinia bacterium, plague, ectoparasites research
- Bacterial Genetics and Biotechnology
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Toxin Mechanisms and Immunotoxins
- Free Radicals and Antioxidants
- Microbial infections and disease research
- Cancer-related molecular mechanisms research
Zhongnan Hospital of Wuhan University
2022-2025
Wuhan University
2022-2025
Sichuan University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
State Key Laboratory of Biotherapy
2022-2024
Henan University of Science and Technology
2022-2024
Luoyang Institute of Science and Technology
2022
Tibet Autonomous Region People's Hospital
2022
West China Medical Center of Sichuan University
2021-2022
Luoyang Normal University
2022
Article13 January 2022Open Access Source DataTransparent process Inhibition of NPC1L1 disrupts adaptive responses drug-tolerant persister cells to chemotherapy Zhe Zhang orcid.org/0000-0001-7509-6965 Laboratory Aging Research and Cancer Drug Target, State Key Biotherapy Center, National Clinical Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, School Basic Medical Sciences & Forensic Medicine, Collaborative Innovation Biotherapy, Contribution: Conceptualization, Data...
Microglia pyroptosis-mediated neuroinflammation is thought to be the crucial pathogenesis of sepsis-associated encephalopathy (SAE). Erbin has been reported associated with various inflammatory diseases. However, role in SAE and relationship between microglia pyroptosis are unknown. In this study, we investigated promising underlying molecular mechanism regulation pyroptosis.WT knockout mice underwent cecum ligation perforation (CLP) induce SAE. Primary mouse BV2 cells were treated...
Streptococcus suis (S. suis) is a zoonotic pathogen with global distribution, which causes serious diseases in both humans and animals economic losses the swine industry. As antibiotic resistance increases, there an urgent imperative to explore novel antibacterial alternatives. In present study, we selected anticancer drug 5-fluorouracil (5-FU) approved by Food Drug Administration (FDA) as candidate treat S. infections. The results showed that various pathogens, especially suis, are more...
Abstract Background The high postoperative recurrence rate and refractoriness of relapsed tumors are still a conundrum for the clinical management osteosarcoma (OS). New therapeutic options urgently needed. Depriving nourishment myeloid-derived suppressor cells is novel strategy to improve immunosuppressive tumor microenvironment enhanced OS therapy. Methods We synthesized hyaluronic acid (HA)-modified metal–organic framework combinational chemotherapy immunotherapy OS. Zeolitic Imidazolate...
Antibiotics are the most powerful weapon against bacterial infectious diseases in aquaculture. However, indiscriminate usage of antibiotics often culminates emerging development antibiotic-resistant bacteria, making it imperative to search for novel types antimicrobial agents. This study investigated antibacterial and antivirulence effects vanillic acid (VA) fish pathogen, Vibrio alginolyticus. We showed that VA had a good anti-Vibrio activity with minimal inhibitory concentration (MIC) 1.0...
Background: Sepsis, as a clinically critical disease, usually induces coagulation disorders. It has been reported that ERBB2 Interacting Protein (Erbin) is involved in the development of various inflammatory diseases, and macrophages are regulation disorders sepsis. However, role Erbin sepsis relationship between macrophage function still unclear. Methods: At cellular level, were treated with lipopolysaccharide (LPS) or MEK inhibitor (PD98059), protein expression levels detected by Western...
Abstract Background The increased resistance of bacterial pathogens to fluoroquinolones (FQs), such as norfloxacin and ciprofloxacin, supports the need develop new antibacterial drugs combination therapies using conventional antibiotics. LuxS/AI-2 quorum sensing (QS) system can regulate complex group behaviour Streptococcus suis impact its susceptibility FQs. Objectives We investigated paeoniflorin a novel effective strategy against FQ-resistant S. suis. Methods FIC, AI-2 activity assay,...
Streptococcus suis (S. suis) and Haemophilus parasuis (H. parasuis) are two primary pathogens currently affecting the porcine industry. They often cause encephalitis arthritis. also frequently co-infect in clinical settings. In current study, we identified significant correlations between S. H. parasuis. The results from CI versus RIR suggested that were competitive general. Compared to mono-species biofilm, biomass, bio-volume, thickness of mixed-species biofilms significantly higher, which...
Abstract Mounting attention has been focused on defects of the autophagy-lysosomal pathway in sepsis, however, precise mechanisms governing process sepsis are poorly known. We have previously reported that Erbin deficiency aggravated inflammatory response and organ injuries caused by sepsis. In present study, we found knockout impaired autophagy both muramyl dipeptide (MDP)-induced bone marrow-derived macrophages (BMDMs) mouse liver lung, as detected accumulation LC3-II SQSTM1/p62,...
Streptococcus suis is a significant zoonotic agent affecting both human and pig health poses substantial public concern. The pathogenicity of S. intricately linked to its ability form biofilms express virulence factors, which are regulated by the LuxS/AI-2 quorum sensing (QS) system. Herein, we uncover novel therapeutic avenue demonstrating that 5-fluorouracil (5-FU), an FDA-approved anti-cancer agent, effectively mitigates biofilm formation attenuates suis. Mechanistically, observe...