A5100410074- Drug Transport and Resistance Mechanisms
- Renal Diseases and Glomerulopathies
- Natural Antidiabetic Agents Studies
- Pharmacological Effects and Toxicity Studies
- Nosocomial Infections in ICU
- Toxin Mechanisms and Immunotoxins
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects of Natural Compounds
- PARP inhibition in cancer therapy
- Systemic Sclerosis and Related Diseases
- Tea Polyphenols and Effects
- Polyoxometalates: Synthesis and Applications
- Heat shock proteins research
- Cancer Cells and Metastasis
- Protein Interaction Studies and Fluorescence Analysis
- Cancer therapeutics and mechanisms
- Lipid metabolism and disorders
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Autoimmune and Inflammatory Disorders Research
- Gastroesophageal reflux and treatments
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Chromatography in Natural Products
- Blood transfusion and management
Shanghai Jiao Tong University
2013-2025
XinHua Hospital
2010-2025
First Affiliated Hospital of Zhengzhou University
2025
Gansu Provincial Hospital
2024
Southern University of Science and Technology
2022
State Key Laboratory of Kidney Diseases
2013
Juntendo University
2013
Ospedale Bassini
2013
Ruijin Hospital
2013
University of Bari Aldo Moro
2013
Article13 January 2022Open Access Source DataTransparent process Inhibition of NPC1L1 disrupts adaptive responses drug-tolerant persister cells to chemotherapy Zhe Zhang orcid.org/0000-0001-7509-6965 Laboratory Aging Research and Cancer Drug Target, State Key Biotherapy Center, National Clinical Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, School Basic Medical Sciences & Forensic Medicine, Collaborative Innovation Biotherapy, Contribution: Conceptualization, Data...
Although recent progress provides mechanistic insights into diabetic nephropathy (DN), effective treatments remain scarce. DN, characterized by proteinuria and a progressive decline in renal function, primarily arises from podocyte injury, which impairs the glomerular filtration barrier. Wogonoside, bioactive compound traditional Chinese herb Scutellaria baicalensis, has not been explored for its role DN. This study aimed to investigate therapeutic effects of wogonoside on injury DN...
SERPINA3 (Serpin peptidase inhibitor clade A member 3), also known as a1-antichymotrypsin, is a serine protease involved in wide range of biological processes. Recently, it has been shown to be up-regulated human placental diseases association with hypomethylation the 5' region gene. In present study, we show that promoter transcriptionally activated by three transcription factors (TFs) (SP1, MZF1 and ZBTB7B), level induction being dependent on rs1884082 single nucleotide polymorphism (SNP)...
Gallbladder cancer (GBC) is the most aggressively malignant tumor in bile duct system. The prognosis for patients with GBC extremely poor. Ponicidin a diterpenoid compound extracted and purified from traditional Chinese herb Rabdosia rubescens, showed promising anti-cancer effects variety of tumors. However, has not been investigated GBC.CCK-8, colony formation assay EdU-488 DNA synthesis were performed to investigate effect on cells proliferation. Cell invasion migration assays...
Podocyte lipid accumulation is a potential therapeutic target for diabetic nephropathy (DN). This study was aimed at clarifying the mechanism of Gandi capsule (GDC) ameliorating DN by regulating metabolism podocytes. Network pharmacology methods were performed to screen key molecules and targets GDC constructing molecular-protein interaction network conducting signal pathway enrichment analysis. predicted ameliorate through SIRT1/AMPK/HNF4A pathway. Our results showed that improved renal...
Objective To investigate the epidemiological trends,etiological profiles and disease burden metrics related to postoperative pneumonia following isolated coronary artery bypass grafting (CABG). Methods A retrospective analysis was conducted on data from 518 patients who developed CABG between January 1, 2020, November 30, 2023. Results Postoperative occurred at a rate of 11.34% among cohort (518/4569),which fluctuated by year (P < 0.001). Patients aged 60–80 over 80 years exhibited...
Abstract Background: Despite the existent studies investigating risk factors for postoperative pneumonia (POP) following coronary artery bypass grafting (CABG), comprehensive understanding of POP is constrained by scarcity epidemiological data. Objective: To investigate epidemiology and contributing in patients undergoing isolated CABG, establish a prediction model. Design: A single center, retrospective case-control study. Setting: Seven cardiovascular surgery wards across three campuses...
Gallbladder cancer (GBC) is a highly aggressive malignant in the biliary system with poor prognosis. XPO1 (chromosome region maintenance 1 or CRM1) mediates nuclear export of several proteins, mainly tumor suppressors. Thus, functions as pro-oncogenic factor. KPT-330 (Selinexor) United States Food and Drug Administration approved selective inhibitor that demonstrates good therapeutic effects hematologic cancers. However, function effect have not been reported GBC.We analyzed correlation...
Breast cancer is the most common among women. Pemetrexed, a new generation antifolate drug, one of primary treatments for breast cancer. However, multidrug resistance (MDR) in greatly hampers therapeutic efficacy chemotherapies such as pemetrexed. Nanomedicine emerging promising alternative technique to overcome MDR. Thus, pemetrexed-loaded d-alpha tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS) liposomes (liposomal pemetrexed) were developed strategy MDR pemetrexed...
Loganin, iridoid glycosides, is the main bioactive ingredients in plant Strychnos nux-vomica L. and demonstrates various pharmacological effects, though poor oral bioavailability rats. In this study, intestinal absorption mechanism of loganin was investigated using human Caco‐2 cell monolayer model both apical‐to‐basolateral (A‐B) basolateral‐to‐apical (B‐A) direction; additionally, transport characteristics were systematically at different concentrations, pHs, temperatures, potential...
Immunoglobulin intravenous (IVIG) is widely used in mucocutaneous lymph node syndrome, known as Kawasaki disease (KD). However, the patients' inflammatory response during usage remains unclear. In present study, association between and lymphocyte count children with KD from different ages was evaluated before after IVIG. The medical records of 50 were retrospectively reviewed divided into five groups according to age. As compared data healthy children, relative neutrophil all increased, that...
Cell division cycle 37 (CDC37) is a member of the molecular chaperone family and acts as cochaperone heat shock protein 90 (HSP90), which overexpressed in many cancer types regulator kinase maturation. In this process, CDC37 selectively recognizes stabilizes kinases by forming HSP90‐CDC37‐kinase complex. The protein‐protein interactions (PPIs) HSP90‐CDC37 CDC37‐kinase complexes contribute to malignant tumors, oncogenic cells depend upon expression. Thus, inhibiting disrupt complex reveals...
The Gandi capsule, a famous traditional Chinese medicine (TCM), is hospital preparation that has been widely used in China for decades the treatment of diabetes. aim this study to compare pharmacokinetics four active components capsules, which are primary antidiabetic ingredients, on normal and diabetic Sprague-Dawley rats following oral administration capsules. Baicalin, wogonoside, wogonin, loganin puerarin (internal standard) were prepared using methanol precipitation, separation five was...
Introduction and Aims: To evaluate the efficacy safety of telmisartan combined with clopidogrelin and/or leflunomide for patients lgA nephropathy whether combination therapy surpass in decreasing proteinuria protecting renal function.Methods: We enrolled 400 aged 18-55 years from 13 centers Beijing who had 0.5˜3.5gper day, baseline serum creatinine (SCr) <265.2μmol/L(3mg/ dl).All were eluted by taking 80mg per day 4 weeks then randomly assigned to receive at least 24 treatment + placebo...