A5102791092- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Hepatitis B Virus Studies
- Data-Driven Disease Surveillance
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- Bacteriophages and microbial interactions
- Herpesvirus Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Poxvirus research and outbreaks
- Genomics and Phylogenetic Studies
- Energy and Environment Impacts
- Diabetes and associated disorders
- Evolution and Genetic Dynamics
- Auction Theory and Applications
- Bacterial Genetics and Biotechnology
- Cellular Mechanics and Interactions
- Private Equity and Venture Capital
- Liver Disease and Transplantation
- Kawasaki Disease and Coronary Complications
- Hippo pathway signaling and YAP/TAZ
Institute of Microbiology
2015-2025
General Hospital of Shenyang Military Region
2021
Academy of Military Medical Sciences
2020-2021
First Affiliated Hospital of Xi'an Jiaotong University
2014
Harbin University of Commerce
2011
Modeling SARS-CoV-2 in mice Among the research tools necessary to develop medical interventions treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, high on list are informative animal models with which study viral pathogenesis. Gu et al. developed a mouse model strain was infectious and could cause an inflammatory response moderate pneumonia. Adaptation of this appeared be dependent critical amino acid change, Asn 501 Tyr (N501Y), within receptor-binding domain...
Experimental and computational analyses identify multiple cell populations during the epithelial-to-mesenchymal transition.
We developed a dynamic forecasting model for Zika virus (ZIKV), based on real-time online search data from Google Trends (GTs). It was designed to provide disease (ZVD) surveillance and detection Health Departments, predictive numbers of infection cases, which would allow them sufficient time implement interventions. In this study, we found strong correlation between Zika-related GTs the cumulative reported cases (confirmed, suspected total cases; p<0.001). Then, used in ZIKV epidemics 12...
A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people West Africa, resulting 10,000 deaths. Preliminary analyses of genome sequences 81 EBOV collected from to June Guinea and Sierra Leone suggest that the originated an independent transmission event its natural reservoir followed by sustained human-to-human infections. It been reported variation might have effect on efficacy sequence-based detection candidate therapeutics. However, only limited viral...
Abstract The advancement of next‐generation sequencing (NGS) technologies has been revolutionary for the field evolutionary biology. This technology led to an abundance available genomes and transcriptomes researchers mine. Specifically, can mine various types molecular markers that are vital phylogenetic, ecological studies. Numerous tools have developed extract these from NGS data. However, due insufficient number well‐annotated reference non‐model organisms, it remains challenging obtain...
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus with crude mortality rate of ~35%. Previously, we established human DPP4 transgenic (hDPP4-Tg) mouse model in which studied complement overactivation-induced immunopathogenesis. Here, to better understand the pathogenesis MERS-CoV, role pyroptosis THP-1 cells and hDPP4 Tg mice MERS-CoV infection. We found that infection induced over-activation macrophages. The hDPP4-Tg infected overexpressed caspase-1 spleen...
Abstract Coronavirus disease 2019 (COVID-19) threatens global public health and economy. In order to develop safe effective vaccines, suitable animal models must be established. Here we report the rapid adaption of SARS-CoV-2 in BALB/c mice, based on which a convenient, economical model was developed. Specifically, found that mouse-adapted at passage 6 (MACSp6) efficiently infected both aged young wild-type resulting moderate pneumonia as well inflammatory responses. The elevated infectivity...
Abstract Recently, several thousand people have been killed by the Ebolavirus disease (EVD) in West Africa, yet no current antiviral medications and treatments are available. Systematic investigation of ebolavirus whole genomes during 2014 outbreak may shed light on underlying mechanisms EVD development. Here, using genome-wide screening genome sequences, we predicted four putative viral microRNA precursors (pre-miRNAs) seven mature microRNAs (miRNAs). Combing bioinformatics analysis...
Abstract An ongoing outbreak of monkeypox virus (MPXV) was first reported in the United Kingdom on 6 May 2022. As 17 November, there had been a total 80 221 confirmed MPXV cases over 110 countries. Based data between and 30 June 2022 Kingdom, Spain, Germany, we applied deep learning approach using convolutional neural networks to evaluate parameters outbreak. The basic reproduction number ( R 0 ) estimated be 2.32 which indicates active diffusion since beginning from Spain Germany produced...
Computer-aided promoter design is a major development trend in synthetic engineering. Various deep learning models have been used to evaluate or screen promoters, but there few works on de novo design. To explore the potential ability of generative design, we established diffusion-based model for Escherichia coli. The was completely driven by sequence data and could study essential characteristics natural thus generating promoters similar structure component. We also improved calculation...
Zika virus (ZIKV) infection is an emerging global threat that suspected to be associated with fetal microcephaly. However, the molecular mechanisms underlying ZIKV disease pathogenesis in humans remain elusive. Here, we investigated human protein interaction network using a systemic virology approach, and reconstructed transcriptional regulatory analyze ZIKV-elicited microcephaly pathogenesis. The bioinformatics findings this study show P53 hub of genetic for ZIKV-related...
The transmission pattern of hemorrhagic fever with renal syndrome (HFRS) is associated environmental conditions, including meteorological factors and land-cover. In the present study, association between HFRS (including maximum temperature, relative humidity, rainfall, normalized difference vegetation index) were explored in two typical counties Northeast Northwest China severe outbreaks by using seasonal autoregressive integrated moving average model exogenous variables (SARIMAX). results...
Sierra Leone was the most severely affected country in Western Africa during 2013-2016 outbreak of Ebola virus disease (EVD). Previous genome surveillance studies have revealed origin, diversity, and evolutionary dynamics (EBOV); however, information regarding EBOV sequences is insufficient, especially clinical outcomes, given that correlation between outcomes genetic evolution still not clear. Here, we collected curated a comprehensive data set includes 514 from patients with confirmed EVD...
LuxR, a bacterial quorum sensing-related transcription factor that responds to the signaling molecule 3-oxo-hexanoyl-homoserine lactone (3OC6-HSL). In this study, we employed molecular dynamics simulation and Molecular Mechanics Generalized Born Surface Area (MM-GB/SA) method rationally identify residues in Vibrio fischeri LuxR are important for its interaction with 3OC6-HSL. Isoleucine-46 was selected engineering as key residue 3OC6-HSL-LuxR-I46F would have strongest binding energy 3OC6-HSL...
Ebola virus (EBOV), a member of the filovirus family, is an enveloped negative-sense RNA that causes lethal infections in humans and primates. Thousands people have died from disease (EVD) West Africa, no specific antiviral medication treatment been approved for EVD. Although development EBOV vaccine promising, immunity to any not immediate. Here, we computationally analysed structure glycoprotein GP2 (GP2EBOV) designed aptamers recognize inhibit it. The specifically bind conserved arginine...
Abstract We developed a dynamic forecasting model for Zika virus (ZIKV), based on real-time online search data from Google Trends (GTs). It was designed to provide disease (ZVD) surveillance Health Departments with early warning, and predictions of numbers infection cases, which would allow them sufficient time implement interventions. used correlation ZIKV epidemics Zika-related in GTs between 12 February 25 August 2016 construct an autoregressive integrated moving average (ARIMA) (0, 1, 3)...