A5045314927- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Porphyrin and Phthalocyanine Chemistry
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Plant Stress Responses and Tolerance
- Vaccine Coverage and Hesitancy
- Photoacoustic and Ultrasonic Imaging
- Immune cells in cancer
- Drug Solubulity and Delivery Systems
- Viral gastroenteritis research and epidemiology
- Neuropeptides and Animal Physiology
- Respiratory viral infections research
- Virus-based gene therapy research
- Lipid Membrane Structure and Behavior
- Advanced Fluorescence Microscopy Techniques
- Bacteriophages and microbial interactions
- Plant Reproductive Biology
- Microbial Metabolites in Food Biotechnology
- Advanced Drug Delivery Systems
University at Buffalo, State University of New York
2014-2025
Xuzhou Medical College
2023-2025
Guangxi University
2025
Anhui Normal University
2025
National Vaccine and Serum Institute
2021-2024
National Institute for Radiological Protection
2018-2024
The University of Texas Southwestern Medical Center
2024
The University of Texas at Dallas
2023-2024
Southwestern Medical Center
2024
Hefei Institutes of Physical Science
2023-2024
Abstract The delivery of therapeutic compounds to target tissues is a central challenge in treating disease. Externally controlled drug release systems hold potential selectively enhance localized delivery. Here we describe liposomes doped with porphyrin–phospholipid that are permeabilized directly by near-infrared light. Molecular dynamics simulations identified novel light-absorbing monomer esterified from clinically approved components predicted and experimentally demonstrated give rise...
Hexamodal imaging using simple nanoparticles is demonstrated. Porphyrin-phospholipids are used to coat upconversion in order generate a new biocompatible material. The characterized vitro and vivo for via fluorescence, upconversion, positron emission tomography, computed Cerenkov luminescence, photoacoustic tomography.
Prompt membrane permeabilization is a requisite for liposomes designed local stimuli‐induced intravascular release of therapeutic payloads. Incorporation small amount (i.e., 5 molar percent) an unsaturated phospholipid, such as dioleoylphosphatidylcholine (DOPC), accelerates near infrared (NIR) light‐triggered doxorubicin in porphyrin–phospholipid (PoP) by order magnitude. In physiological conditions vitro, the loaded drug can be released minute under NIR irradiation, while maintain serum...
Doxorubicin (Dox)-loaded stealth liposomes (similar to those in clinical use) can incorporate small amounts of porphyrin–phospholipid (PoP) enable chemophototherapy (CPT). PoP is also an intrinsic and intrabilayer 64Cu chelator, although how radiolabeling impacts drug delivery has not yet been assessed. Here, we show that radiolabel the stable bilayer preformed Dox-loaded with inclusion 1% ethanol without inducing leakage. Dox-PoP labeled copper behaved nearly identically unlabeled ones...
Abstract NVSI-06-08 is a potential broad-spectrum recombinant COVID-19 vaccine that integrates the antigens from multiple SARS-CoV-2 strains into single immunogen. Here, we evaluate safety and immunogenicity of as heterologous booster dose in BBIBP-CorV recipients randomized, double-blind, controlled, phase 2 trial conducted United Arab Emirates (NCT05069129). Three groups healthy adults over 18 years age (600 participants per group) who have administered two doses 4-6-month, 7-9-month...
The continuous emergence of SARS-CoV-2 variants highlights the need developing vaccines with broad protection. Here, according to immune-escape capability and evolutionary convergence, representative strains carrying hotspot mutations were selected. Then, guided by structural computational analyses, we present a mutation-integrated trimeric form spike receptor-binding domain (mutI-tri-RBD) as broadly protective vaccine candidate, which combined heterologous RBDs from different into hybrid...
We tested wheat ( Triticum aestivum L.) seedlings under five different saline and alkaline stress (9:1 molar ratio of NaCl/Na 2 SO 4 9:1 NaHCO 3 /Na CO , respectively) regimes differing severity for 7 d, comparing growth, germination, ionic balance seedlings, to elucidate the mechanism (high pH) damage wheat, it physiological adaptive stress. found that alkalinity had a more severe effect on than salinity, preventing germination before after recovery, severely inhibiting shoot root growth....
Porphyrin-phospholipid (PoP) liposomes can entrap anti-cancer agents and release them in response to near infrared (NIR) light.Doxorubicin, when remotely loaded via an ammonium sulfate gradient at a high drug-to-lipid ratio, formed elongated crystals that altered liposome morphology could not be into with higher PoP content.On the other hand, irinotecan also but did form large induce elongation.The loading, stability, NIR light-triggered of was by types lipids used presence...
Intratumoral (IT) drug injections reduce systemic toxicity, but delivered volumes and distribution can be inconsistent. To improve IT delivery paradigms, porphyrin-phospholipid (PoP) liposomes are passively loaded with three hydrophilic cargos: sulforhodamine B, a fluorophore; gadolinium-gadopentetic acid, magnetic resonance (MR) agent; oxaliplatin, colorectal cancer chemotherapeutic. Liposome composition is optimized so that cargo retained in serum storage, released less than 1 min exposure...
A TCM formula has played an important role in the treatment of COVID-19 China. However, mechanism action is still unclear.
The increased coronavirus disease 2019 (COVID-19) breakthrough cases pose the need of booster vaccination. We conducted a randomised, double-blinded, controlled, phase 2 trial to assess immunogenicity and safety heterologous prime-boost vaccination with an inactivated COVID-19 vaccine (BBIBP-CorV) followed by recombinant protein-based (NVSI-06-07), using homologous boost BBIBP-CorV as control. Three groups healthy adults (600 individuals per group) who had completed two-dose vaccinations 1-3...
Liposomes incorporating porphyrin–phospholipid (PoP) can be formulated to release entrapped contents in response near-infrared (NIR) laser irradiation. Here, we examine effects of chelating copper or zinc into the PoP. Cu(II) and Zn(II) PoP liposomes, containing 10 molar % HPPH-lipid, exhibited unique photophysical properties released cargo NIR light. Cu-PoP liposomes minimal fluorescence reduced production reactive oxygen species upon Zn-PoP retained singlet generation properties; however,...
Cobalt has been applied as liners in current Cu interconnect and even conductors next-generation interconnect. In this work, effects of corrosion inhibitors 1, 2, 4-triazole (TAZ) on Co chemical corrosion, galvanic between Co, polishing properties the H2O2 based acidic slurry have systematically investigated. Results show that 5 mM TAZ yields a low static etching removal rate with selectivity about 1: 1 for to Cu, applicable barrier/ CMP, while 100 high same selectivity, via trench CMP. It...
Significance Hemagglutinin (HA) is the major influenza virus surface protein and a prime antigen candidate for vaccine development using recombinant subunit approaches. Adjuvants often are used to enhance immunogenicity of proteins. Here, we show that next-generation adjuvant system seamlessly sequesters presents antigens on immunogenic liposomes improves functional HA in mice ferrets. The potential dose sparing multivalent presentation demonstrated this approach.
Large-scale populations in the world have been vaccinated with COVID-19 vaccines, however, breakthrough infections of SARS-CoV-2 are still growing rapidly due to emergence immune-evasive variants, especially Omicron. It is urgent develop effective broad-spectrum vaccines better control pandemic these variants. Here, we present a mosaic-type trimeric form spike receptor-binding domain (mos-tri-RBD) as vaccine candidate, which carries key mutations from Omicron and other circulating Tests rats...
Cationic liposomes have been used for targeted drug delivery to tumor blood vessels, via mechanisms that are not fully elucidated. Doxorubicin (Dox)-loaded were prepared incorporate a cationic lipid; 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), along with small amount of porphyrin-phospholipid (PoP). Near-infrared (NIR) light caused release entrapped Dox PoP-mediated DOTAP photo-oxidation. The formulation was optimized enable extremely rapid NIR light-triggered (i.e., in 15 seconds),...
Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well disease, resulting in changes the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our understanding of disease transition from infection pneumococcus serving model organism. Using conserved surface proteins highly...
<title>Abstract</title> Liposomal doxorubicin (Dox), a treatment option for recurrent ovarian cancer, often suffers from suboptimal biodistribution and efficacy, which might be addressed with precision drug delivery systems. Here, we introduce catheter-based endoscopic probe designed multispectral, quantitative monitoring of light-triggered release. This tool utilizes red-light photosensitive porphyrin-phospholipid (PoP), is encapsulated in liposome bilayers to enhance targeted delivery. By...