A5100755472- Advanced Glycation End Products research
- Genetic and phenotypic traits in livestock
- Nitric Oxide and Endothelin Effects
- Cardiac Fibrosis and Remodeling
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Genetic Mapping and Diversity in Plants and Animals
- Vaccine Coverage and Hesitancy
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- vaccines and immunoinformatics approaches
- Receptor Mechanisms and Signaling
- Lipid metabolism and disorders
- Viral gastroenteritis research and epidemiology
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tea Polyphenols and Effects
- Advanced Breast Cancer Therapies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Heme Oxygenase-1 and Carbon Monoxide
- Multiple and Secondary Primary Cancers
Beijing University of Chinese Medicine
2018-2025
Chinese Academy of Agricultural Sciences
2014-2025
Southwest Minzu University
2024
The First People's Hospital of Guiyang
2024
Guiyang Medical University
2024
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2022-2023
Biological E (India)
2022
Henan Cancer Hospital
2014-2022
Zhengzhou University
2014-2022
Chinese People's Liberation Army
2022
Inflammation is a condition that underscores many cardiovascular pathologies including endothelial dysfunction, but no link yet established between the vascular pathology of metabolic syndrome with particular inflammatory cytokine. We hypothesized impairments in coronary function obese prediabetic caused by TNF-α overexpression. To test this, we measured endothelium-dependent (acetylcholine) and -independent vasodilation (sodium nitroprusside) isolated, pressurized small arteries from lean...
We hypothesized that impaired nitric oxide (NO)-dependent dilation (endothelial dysfunction) in Type 2 diabetes results, part, from elevated production of superoxide (O •− ) induced by the interaction advanced glycation end products (AGE)/receptor for AGE (RAGE) and TNF-α signaling. assessed role AGE/RAGE signaling endothelial dysfunction diabetic (Lepr db mice evaluation function isolated coronary resistance vessels normal control (nondiabetic, m Lepr mice. Although to...
Background— We tested whether tumor necrosis factor (TNF)-α increases arginase expression in endothelial cells as one of the primary mechanisms by which this inflammatory cytokine compromises function during ischemia-reperfusion (I/R) injury. Methods and Results— Mouse hearts were subjected to 30 minutes global ischemia followed 90 reperfusion their vasoactivity before after I/R was examined wild-type (WT), knockout (TNF −/− ), TNF 1.6 ++/++ ) mice. In WT mice, dilation endothelium-dependent...
Abstract NVSI-06-08 is a potential broad-spectrum recombinant COVID-19 vaccine that integrates the antigens from multiple SARS-CoV-2 strains into single immunogen. Here, we evaluate safety and immunogenicity of as heterologous booster dose in BBIBP-CorV recipients randomized, double-blind, controlled, phase 2 trial conducted United Arab Emirates (NCT05069129). Three groups healthy adults over 18 years age (600 participants per group) who have administered two doses 4-6-month, 7-9-month...
We hypothesized that neutralization of TNF-α at the time reperfusion exerts a salubrious role on endothelial function and reduces production reactive oxygen species. employed mouse model myocardial ischemia-reperfusion (I/R, 30 min/90 min) administered neutralizing antibodies reperfusion. I/R elevated expression (mRNA protein), whereas administration anti-TNF-α before attenuated expression. detected in vascular smooth muscle cells, mast macrophages, but not cells. induced dysfunction...
Extranodal natural killer (NK)/T-cell lymphoma is an aggressive lymphoid tumor. Optimal treatment strategies have not yet been fully defined. To explore a more effective treatment, we conducted sequential chemoradiotherapy (SCRT) and evaluated the safety efficacy. Seventy-eight patients (51 males, 27 females) were analyzed. The complete response (CR) rate was higher for in SCRT group (90.9%) than radiotherapy (77.8%; p = 0.124). relapse (RR) death (DR) lower (RR: 6.7% vs 33.3%, < 0.001; DR:...
Objective: Myocardial contractility is enhanced in transgenic (TG) mice with cardiac-restricted overexpression of the α1A-adrenergic receptors (α1A-AR). We tested hypothesis that this inotropy protects against dysfunction and remodeling after myocardial infarction (MI).
Podocyte apoptosis is the common pathological basis for progression of various kidney diseases. The overexpression NOX4, a key enzyme involved in oxidative stress, has been proved to participate occurrence podocyte apoptosis. Autophagy kind adaptive response cells under stress. However, as "double-edged sword", effect autophagy on different and conditions complex variable, which not fully explained yet. Morroniside, extracted from traditional medicinal plant Cornus officinalis, remarkable...
Fatty acid composition (FA) is an important indicator of meat quality in beef cattle. We investigated potential functional candidate genes for FA cattle by integrating genomic and transcriptomic dataset through multiple strategies. In this study, we observed 65 SNPs overlapping with five (CCDC57, FASN, HDAC11, ALG14, ZMAT4) using two steps association based on the imputed sequencing variants. Using traits GWAS, further identified three significant located upstream FASN one SNP...
Over the past two decades, a systematic elucidation of overall trajectory and clinical translation stem cell research in kidney diseases has been lacking. To address this gap, we conducted bibliometric analysis trial search focusing on period from 2005 to 2025, thereby mapping global landscape diseases. Our results indicate growing body literature, accompanied by extensive international collaborations, with United States China leading output. In terms themes, mesenchymal cells continue...
Cardiac fibrosis is a hallmark of heart disease and plays vital role in cardiac remodeling during diseases, including hypertensive disease. Hexarelin one series synthetic growth hormone secretagogues (GHSs) possessing variety cardiovascular effects via action on GHS receptors (GHS-Rs). However, the hexarelin vivo has not yet been investigated. In present study, spontaneously rats (SHRs) were treated with alone or combination GHS-R antagonist for 5 wk from an age 16 wk. treatment...
QiDiTangShen granules (QDTS) have been proven to reduce the proteinuria in patients with diabetic nephropathy (DN) effectively. The present study was aimed investigate mechanism underlying QDTS's renoprotection. main components of QDTS were identified by ultra-high liquid chromatography-tandem mass spectrometry and pharmacological databases, among which active screened oral bioavailability drug-likeness. Their regulation on autophagy-related nutrient-sensing signal molecules (AMPK, SIRT1,...
In addition to its role as a barrier between blood and tissues, the vascular endothelium is responsible for synthesis released of number vasodilators including prostaglandins, nitric oxide endotheliumderived hyperpolarizing factor (EDHF).As one these vasodilators, specific nature EDHF has not been fully elucidated, although roles have proposed.Importantly, many conditions, such hypertension, hyperlipidemia, heart failure, ischemiareperfusion diabetes mellitus comprise endothelial dysfunction...
Diabetes mellitus is a major risk factor to impair endothelial function and induce cardiovascular diseases. TNF-alpha (TNF) expressed during variety of inflammatory conditions. We hypothesized that impairment in coronary type 2 diabetes due the overexpression TNF receptors (TNFRs). Endothelium-dependent (acetylcholine, ACh) -independent vasodilation (sodium nitroprusside, SNP) isolated, pressurized (60 cmH(2)O) arteries (50-100 μm) from lean control Zucker diabetic fatty (ZDF, model...
Abstract An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as booster dose in subjects aged 18 years older from United Arab Emirates (UAE), who had administered two or three doses inactivated BBIBP-CorV at least 6 months prior enrollment. The participants were randomly assigned with 1:1 receive NVSI-06-09 BBIBP-CorV. primary outcomes against severe acute...
Diabetic nephropathy (DN) is a microvascular complication induced by diabetes mellitus (DM), which can affect life quality and long-term prognosis of patients with DM. Angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) are currently recommended for treating DN proteinuria, but receiving ACEI/ARB at risk elevated serum creatinine or potassium levels. Based on the "yin-yang" theory traditional Chinese medicine, present study explored effect QiDiTangShen (QDTS)...
To construct a traditional Chinese medicine (TCM) syndrome elements diagnostic scale for diabetic kidney disease (DKD).A total of 492 DKD patients were included in the study. TCM symptoms, signs and tongue manifestation information collected, which constituted items scale. Frequency dominance method was used to screen core items. Cluster analysis factor identify elements. Correlation coefficient regression determine Regression items, threshold established by receiver operating characteristic...
The kinetics of subsurface demineralization tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume solution buffered to pH = 4 maintain constant composition; and (2) small (~ 3 mL), initially at 4, so that the degree saturation surface increased as dissolved. At composition, change lesion depth, Y, time, T, followed linear relation, Y= α + bT, for T> 44± 5 h. Before this relation could be approximated one...
To measure lamina cribrosa thickness (LCT) and anterior surface depth (ALCSD) in primary open-angle glaucoma (POAG), chronic angle-closure (CPACG), control patients using spectral-domain optical coherence tomography (SD-OCT) examine its association with relevant ocular parameters.In this cross-sectional study, 61 healthy volunteers (61 eyes), 65 POAG (65 55 CPACG (55 eyes) were recruited to obtain radial B-scans of the optic nerve head by way enhanced imaging Heidelberg SD-OCT. The obtained...