A5100765297- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Genetic and phenotypic traits in livestock
- MicroRNA in disease regulation
- Protein Hydrolysis and Bioactive Peptides
- Glaucoma and retinal disorders
- RNA and protein synthesis mechanisms
- Bone Metabolism and Diseases
- Sperm and Testicular Function
- Biochemical effects in animals
- Metabolism, Diabetes, and Cancer
- Animal Genetics and Reproduction
- Meat and Animal Product Quality
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Reproductive Biology and Fertility
- Coagulation and Flocculation Studies
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Probiotics and Fermented Foods
- Reproductive Physiology in Livestock
Ocean University of China
2024-2025
Jilin University
2016-2025
Dalian Institute of Chemical Physics
2025
Chinese Academy of Sciences
2025
Sichuan Agricultural University
2024
Jilin Medical University
2021-2024
Second Hospital of Shandong University
2013-2024
Second Affiliated Hospital of Jilin University
2017-2023
Soochow University
2022
Tianjin University of Science and Technology
2022
PNI/RA-Amps is an injectable thermo-reversible dressing triggered by body temperature, and exhibits a rapid reversible sol–gel–sol transition of ∼23 s. MGF E peptide was loaded into the hydrogel to enable bacteriostasis, hemostasis wound healing.
Insulin-like growth factor 2 mRNA binding protein (IGF2BP2) is a member of the IGF2BP family consisting IGF2BP1~3 with capacity to many transcripts and regulating RNA stability, localization, translation. In this study, we discovered that expression IGF2BP2 was upregulated led poor prognosis in pancreatic ductal adenocarcinoma (PDAC). gradually elevated from normal pancreas, intraepithelial neoplasia PDAC an LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre mouse model. Furthermore, demonstrated...
Antler ossified tissue has been widely used for the extraction of bioactive peptides. In this study, collagen was prepared from antler via acetic acid and pepsin. Five different proteases were to hydrolyze hydrolysate treated by neutrase (collagen peptide named ACP) showed highest DPPH radical clearance rate. The process ACP optimized response surface methodology, optimal conditions as follows: a temperature 52 °C, pH 6.1, an enzyme concentration 3200 U/g, which resulted in maximum rate...
Diabetic retinopathy (DR), one of the most common complications late‑phase diabetes, is associated with ectopic apoptosis microvascular cells. Gastrodin, a phenolic glucoside derived from Gastrodia elata Blume, has been reported to have antioxidant and anti‑inflammation activities. The aim present study was investigate effects gastrodin on high glucose (HG)‑induced human retinal endothelial cell (HREC) injury its underlying mechanism. results demonstrated that HG induced in HRECs, which...
As an attractive biomaterial for bone reconstruction, injectable biomaterials have many prominent characteristics such as good biocompatibility and bone-filling ability. However, there are weak load-bearing scaffolds. In this study, polyvinyl alcohol (PVA) bioactive glass (BAG) were interpenetrated into sodium alginate (SA) network to obtain self-enhanced hydrogel. The optimum ratio of PVA/SA/BAG hydrogel was determined based on injectability, gelation time chemical characterization. Results...
Lactic-acid-bacteria-derived bacteriocins are used as food biological preservatives widely. Little information is available on the impact of bacteriocin intake with gut microbiota in vivo. In this study, effects fermented milk supplemented nisin (FM-nisin) or plantaricin Q7 (FM-Q7) from Lactiplantibacillus plantarum inflammatory factors and mice were investigated. The results showed that FM-nisin FM-Q7 up-regulated IFN-γ down-regulated IL-17 IL-12 serum significantly. TNF-α IL-10 while them....
DNA demethylation catalysed by the ten-eleven translocation (TET) protein is an important step during extensive global epigenetic reprogramming in mammals. However, whether TET proteins play a key role development of bovine pre-implanted embryos still unclear. In this study, we utilized dimethyloxallyl glycine (DMOG), small-molecule inhibitor protein, to impede enzymatic activity and explore subsequent effects on parthenogenetic embryo development. We first detected expression family,...
The purpose is to assess the diagnostic ability for early glaucoma of macular ganglion cell–inner plexiform layer (GCIPL) thickness in a Chinese population including suspects. A total 367 eyes with primary open-angle (168 glaucoma, 78 moderate and 121 advanced glaucoma), 52 ocular hypertension (OHT), 59 enlarged cup-to-disc ratio (C/D), 225 normal were included. GCIPL (average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, inferotemporal), retinal nerve fiber (RNFL)...
Insulin-like growth factor 1 (IGF-1) is considered to be a crucial gene in the animal development of bone and body size. In this study, unique synonymous mutation (c.258 A > G) IGF-1 was modified with an adenine base editor observe developmental situation mutant mice. Significant expression differences molecular mechanisms among vectors different alanine codons were explored. Although modification single codon rarely interferes phenotypes, we observed that secretion between 8-week-old...
is a serious pathogen and can exacerbate harmful effects through the formation of biofilm. Inhibition or reduction in
Small-pore aluminophosphate (AlPO) molecular sieves (MSs), particularly those in the ABC-6 family, have gained significant attention for their unique capabilities selective adsorption and energy storage. However, developing new synthesis strategies designing AlPOs with three-dimensional (3D) channel systems determining structures of nanosized novel AlPO MSs remain challenging tasks. In this study, we introduce a small-pore 3D system, named DNL-17, synthesized by using diquaternary ammonium...
This study aimed to investigate the function of miRNA 21-5p in regulating differentiation C2C12 myoblasts and intramuscular lipid droplet accumulation myotubes. The role miR-21-5p proliferation myofibroblasts intracellular was analyzed using bioinformatics, CCK-8 assay, RT-qPCR, immunoblotting, immunofluorescence staining, Oil Red O staining. Analysis porcine BodyMap transcriptomic data revealed differential expression skeletal muscle adipose tissue. Bioinformatics analysis combined with a...
The oral administration of probiotics is a promising strategy to regulate the host-intestinal flora balance and improve health. Nevertheless, adverse gastrointestinal (GI) conditions affect activity free native probiotics. In this study, novel probiotic encapsulation system based on milk exosomes (mExos) DSPE-PEG-PBA was developed. mExos acted as shield protect from harsh GI environments, served bridge between coated were characterized by transmission electron microscopy (TEM), Fourier...
A process for extracting the antler tip peptides (ATPs) from Sika deer ( Cervus nippon ) tips was optimized using a method that combines single‐factor experiment and response surface methodology. The optimal conditions involved papain as hydrolase, an enzyme concentration of 5000 U/g, hydrolysis time 3.0 h, temperature 52.0°C, pH 7.10, substrate 14%. Under these conditions, clearance rate 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical 73.05 ± 1.49%, degree (DH) 19.43 1.06%. antioxidant...
The oxidative balance and inflammatory responses play important roles in wound healing. Plant-derived exosome-like nanovesicles exhibit antioxidant or anti-inflammatory properties. However, their effects underlying molecular mechanisms of action healing remain unclear. Herein, coriander-derived (CDENs) are isolated characterized. It is found that the CDENs can be internalized by HaCaT cells mouse skin tissue, promoting cell migration, scavenging reactive oxygen species (ROS) increasing...
Dexamethasone (Dex) has been widely used as a potent anti-inflammatory, antishock, and immunosuppressive agent. However, high dose or long-term use of Dex is accompanied by side effects including skeletal muscle atrophy, whose underlying mechanisms remain incompletely understood. A number microRNAs (miRNAs) have shown to play key roles in atrophy. Previous studies showed significantly increased miR-322 expression Dex-treated C2C12 myotubes. In our study, the glucocorticoid receptor (GR) was...