A5068064110- Cancer-related Molecular Pathways
- Immune cells in cancer
- Chronic Kidney Disease and Diabetes
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Hypertrophic osteoarthropathy and related conditions
- Galectins and Cancer Biology
- Dialysis and Renal Disease Management
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal Diseases and Glomerulopathies
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- CRISPR and Genetic Engineering
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Biomedical Ethics and Regulation
- Biomarkers in Disease Mechanisms
- Kruppel-like factors research
- Trace Elements in Health
- Genetics, Aging, and Longevity in Model Organisms
Brigham and Women's Hospital
2016-2025
Harvard University
2012-2025
Taipei Medical University-Shuang Ho Hospital
2024
Guru Nanak Dev University
2021
University of Delhi
2021
National Centre for Cell Science
2006-2017
Savitribai Phule Pune University
2015-2017
International Advanced Research Centre for Powder Metallurgy and New Materials
2015
Indian Institute of Technology Bombay
2007-2015
Metabolism and Renal Physiology
2015
Accumulation of IL-17-producing Th17 cells is associated with the development multiple autoimmune diseases; however, contribution microRNA (miRNA) pathways to intrinsic control remains unclear. Here, we demonstrated that miR-21 expression elevated in and mice lacking have a defect differentiation are resistant experimental encephalomyelitis (EAE). Furthermore, determined promotes by targeting depleting SMAD-7, negative regulator TGF-β signaling. Moreover, decreases miR-21-deficient T were...
Macrophages (Mø) are integral in ischemia/reperfusion injury-incited (I/R-incited) acute kidney injury (AKI) that leads to fibrosis and chronic disease (CKD). IL-34 CSF-1 share a receptor (c-FMS), both cytokines mediate Mø survival proliferation but also have distinct features. is central repair destruction. We tested the hypothesis IL-34-dependent, Mø-mediated mechanisms promote persistent ischemia-incited AKI worsens subsequent CKD. In renal I/R, time-related magnitude of CKD were markedly...
Nephrotoxicity due to drugs and environmental chemicals accounts for significant patient mortality morbidity, but there is no high throughput in vitro method predictive nephrotoxicity assessment. We show that primary human proximal tubular epithelial cells (HPTECs) possess characteristics of differentiated rendering them desirable use such systems. To identify a reliable biomarker nephrotoxicity, we conducted multiplexed gene expression profiling HPTECs after exposure six different...
Chronic inflammation can drive tumor development. Here, we have identified microRNA-146a (miR-146a) as a major negative regulator of colonic and associated tumorigenesis by modulating IL-17 responses. MiR-146a-deficient mice are susceptible to both colitis-associated sporadic colorectal cancer (CRC), presenting with enhanced tumorigenic signaling. Within myeloid cells, miR-146a targets RIPK2, NOD2 signaling intermediate, limit cell-derived IL-17-inducing cytokines restrict IL-17....
Maladaptive repair following kidney tubular injury leads to the development of interstitial fibrosis, a pathology common chronic diseases (CKD). Dysfunctional DNA damage response plays an important role in progression CKD. We found that BRCA1 expression was increased kidneys patients with CKD and fibrotic mice. Exon 11 deletion Brca1 proximal tubule cells (PTCs) mice subjected ischemic or nephrotoxic (aristolochic acid) resulted reduced number senescent cells, as assessed by decrease...
Recent population-based epidemiological studies strongly hint towards a link between obesity and its occurrence as well progression of several cancers including melanoma. Although effects on breast, colon liver have been extensively investigated, the links melanoma remain largely unexplored. Present study aimed to understand effect high fat diet-induced weight gain susceptibility C57BL/6J mice For this, routinely were fed diet for 6 months (HFD mice). Subsequently, mouse cells injected...
Signal transduction and activator of transcription 3 (STAT3) is a key factor implicated in the pathogenesis kidney fibrosis. Although Stat3 deletion tubular epithelial cells known to protect mice from fibrosis, vFoxd1 remains unclear. Using Foxd1-mediated knockout mice, CRISPR, inhibitors STAT3, we investigate its function. STAT3 phosphorylated acute injury, whereas it expanded interstitial fibrosis humans. protects folic-acid- aristolochic-acid-induced Mechanistically, upregulates...
Kidney injury molecule-1 (KIM-1)/T cell Ig and mucin domain-containing protein-1 (TIM-1) is upregulated more than other proteins after AKI, it highly expressed in renal damage of various etiologies. In this capacity, KIM-1/TIM-1 acts as a phosphatidylserine receptor on the surface injured proximal tubular epithelial cells, mediating phagocytosis apoptotic may also act costimulatory molecule for immune cells. Despite recognition KIM-1 an important therapeutic target kidney disease, regulators...
CKD is the gradual, asymptomatic loss of kidney function, but current tests only identify when significant has already happened. Several potential biomarkers have been reported, none approved for preclinical or clinical use. Using RNA sequencing in a mouse model folic acid-induced nephropathy, we identified ten genes that track fibrosis development, common pathologic finding patients with CKD. The gene expression all candidates was confirmed to be significantly higher (approximately ten-...
Secreted modular calcium-binding protein 2 (SMOC2) belongs to the secreted acidic and rich in cysteine (SPARC) family of matricellular proteins whose members are known modulate cell-matrix interactions. We report that SMOC2 is upregulated kidney tubular epithelial cells mice humans following fibrosis. Using genetically manipulated with overexpression or knockdown, we show critically involved progression Mechanistically, found activates a fibroblast-to-myofibroblast transition (FMT) stimulate...
Highlights•Within DCs, Smad7 inhibits PD1 ligands, CD103, and TGF-β, limiting Treg induction•Within CD4+ T cells, PD1, PD1-mediated differentiation•Smad7 deficiency in DCs or cells mitigates DSS cell transfer colitis models•Smad7-antisense inhibitor, agonizing via PDL1/2-Fc, ameliorates colitisSummarySmad7, a negative regulator of TGF-β signaling, has been implicated the pathogenesis treatment inflammatory bowel diseases (IBDs), including Crohn's disease (CD) ulcerative (UC). Here, we found...
A disequilibrium between immunosuppressive Tregs and inflammatory IL-17-producing Th17 cells is a hallmark of autoimmune diseases, including multiple sclerosis (MS). However, the molecular mechanisms underlying Treg imbalance in CNS autoimmunity remain largely unclear. Identifying factors that drive this high clinical interest. Here, we report major disease-promoting role for microRNA-92a (miR-92a) autoimmunity. miR-92a was elevated experimental encephalomyelitis (EAE), its loss attenuated...
In general, the activation of extracellular recognition kinase (ERK) cascade is implicated in exerting tumorigenic effects. Conversely, recent studies suggest that ERK may also have role DNA‐damage induced apoptosis [Wang, X., Martindale, J.L. and Holbrook, N.J. (2000) Requirement for cisplatin‐induced apoptosis. J. Biol. Chem. 275, 39435–39443; Schweyer S., Soruri A., Meschter O., Heintze Zschunke F., Miosge N., Thelen P., Schlott T., Radzun H.J. Fayyazi, A. (2004) Cisplatin‐induced human...
Metallo-organic compounds are interesting to study for their antitumor activity and related applications. This paper deals with the syntheses, characterization, structure determination of a copper complex anthracenyl terpyridine (1) its plasmid cleavage cytotoxicity towards different cancer cell lines. The binds CT-DNA through partial intercalation mode. studies carried out using pBR322 pUC18 resulted in formation all three forms DNA. Plasmid non-redoxable Zn2+ (2) supported role redox 1. 1...
Fibrinogen (Fg) has been implicated in the pathogenesis of several fibrotic disorders by acting as a profibrotic ligand for variety cellular surface receptors and modulating provisional fibrin matrix formed after injury. We demonstrated increased renal Fg expression unilateral ureteral obstruction folic acid (FA) nephropathy mice, respectively. Urinary excretion was also FA nephropathy. Using vitro vivo approaches, our results suggested that IL-6 mediates STAT3 activation kidney fibrosis...
Significance Statement Macrophages and autoantibodies play a central role in the pathology of lupus nephritis patients with MRL- Faslpr mouse model. The authors demonstrate that IL-34 its two receptors, cFMS PTPRZ, are upregulated kidney advancing mice. Genetically deleting these mice suppresses systemic illness via macrophage- autoantibody-mediated mechanisms within outside kidney. also found have elevated serum urine; intrarenal expression IL-34, cFMS, PTPRZ similar to displayed mice;...
Abstract Background p53 is the most studied tumor suppressor and its overexpression may or not cause cell death depending upon genetic background of cells. degraded by human papillomavirus (HPV) E6 protein in cervical carcinoma. Several stress activated kinases are known to phosphorylate and, among them cyclin dependent kinase 5 (Cdk5) one neuronal system. Recently, involvement Cdk5 phosphorylating has been shown certain cancer types. Phosphorylation at specific serine residues essential for...