A5047820165- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Heat shock proteins research
- Genetic Syndromes and Imprinting
- Cardiovascular Function and Risk Factors
- Renin-Angiotensin System Studies
- Acute Kidney Injury Research
- Head and Neck Cancer Studies
- Renal and Vascular Pathologies
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- ATP Synthase and ATPases Research
- Renal and related cancers
- Cardiac Fibrosis and Remodeling
- Cardiovascular and exercise physiology
- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Lipoproteins and Cardiovascular Health
- Vitamin D Research Studies
- Cardiomyopathy and Myosin Studies
- Angiogenesis and VEGF in Cancer
- Dialysis and Renal Disease Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Aortic aneurysm repair treatments
Jiangxi Provincial Cancer Hospital
2025
Harvard University
2012-2023
Brigham and Women's Hospital
2014-2023
Liaoning Cancer Hospital & Institute
2023
Nanchang University
2023
Toronto Public Health
2019
Jilin University
2019
Bridge University
2016
University Hospital Coventry
2012
Beth Israel Deaconess Medical Center
2008
Klotho is known to function as a cofactor for the phosphatonin, fibroblast growth factor (FGF)-23 at kidney. FGF-23 levels rise in chronic kidney disease (CKD) despite progression of accelerated vascular calcification. There are currently conflicting data on whether may exhibit direct vasculoprotective effects CKD.In this study, we describe first time endogenous expression human arteries and aortic smooth muscle cells. We show that CKD state deficiency promoted by circulating stress factors,...
α-Klotho has emerged as a powerful regulator of the aging process. To date, expression profile in human tissues is unknown, and its existence some tissue types subject to much controversy.This first study characterize systemwide transmembrane humans. We have employed next-generation targeted proteomic analysis using parallel reaction monitoring with conventional antibody-based methods determine spatial distribution health.The from various organ systems, including arterial, epithelial,...
Abstract HIV-1 infection has significant effect on the immune system as well nervous system. Breakdown of blood-brain barrier (BBB) is frequently observed in patients with HIV-associated dementia (HAD) despite lack productive human brain microvascular endothelial cells (HBMEC). Cellular products and viral proteins secreted by infected cells, such Gp120 envelope glycoprotein, play important roles BBB impairment development. HBMEC are a major component BBB. Using cocultures astrocytes model...
Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular in the presence chronic due an accumulation reactive oxygen species and decreased microvascular perfusion myocardium. Methods. To isolate exclusive effect disease-induced cardiac disease, we studied knockout mouse strain (GPx3-/-) setting surgery-induced CKD. Results. Ribonucleic acid (RNA) microarray screening non-stimulated GPx3-/-...
Endothelial cells (ECs) express fibroblast growth factor (FGF) receptors and are metabolically active after treatment with FGF-23. It is not known if this effect α-Klotho independent or mediated by humoral endogenous endothelial α-Klotho. In the present study, we aimed to characterize EC expression within human vascular tree investigate potential role of in determining FGF-23 regulation. Human tissue ECs from various organs were used for immunohistochemistry Western blot. Primary cultures...
•Patients with dmNPC receiving chemotherapy plus anti-PD-1 mAbs had an ORR of 92.0% and a median PFS 20 months.•Chemotherapy monoclonal antibodies followed by LRRT improves survival outcomes.•Early clearance EBV DNA is biomarker for identifying suitable candidates in the era immunotherapy. BackgroundWe aimed to investigate efficacy locoregional radiotherapy (LRRT) patients de novo metastatic nasopharyngeal carcinoma (dmNPC) combined anti-programmed cell death receptor-1 (anti-PD-1 mAbs) as...
The present study was designed to investigate the effect of previous heat shock treatment on mitochondria function heart during a cecal ligation and puncture (CLP)-induced sepsis model. Rats heated group were by whole-body hyperthermia 24 h before CLP operation. Cardiac freshly collected 9 18 after CLP, indicating early late sepsis, respectively. expressions protein 72 (Hsp72), glucose-regulated 75 (Grp75), mitochondrial complexes I, II, III, IV evaluated Western blot immunochemical...
Aims: Berberine (BBR) improves beta-cell function in Type 2 diabetes (T2D) because of its anti-apoptotic activity, and our laboratory developed a new preparation named Huang-Gui Solid Dispersion (HGSD) to improve the oral bioavailability BBR.However, mechanism by which BBR inhibits apoptosis is unclear.We hypothesized that Group VIA Ca 2+ -Independent Phospholipase A2 (iPLA2β)/Cardiolipin(CL)/Opa1 signaling pathway could exert protective role T2D regulating HGSD inhibit β-cell through...
This study was performed to investigate the relationship of pretreatment neutrophil count and neutrophil-to-lymphocyte ratio (NLR) with prognosis nasopharyngeal carcinoma (NPC), as well establish an NLR-related nomogram predict survival in patients NPC. In total, 747 NPC were enrolled between January 2005 2015 at our hospital. Kaplan-Meier analysis used evaluate overall (OS), progression-free (PFS), distant metastasis-free (DMFS), comparisons made using log-rank test. Univariate multivariate...
Patients with advanced chronic kidney disease (CKD) mostly die from sudden cardiac death and recurrent heart failure. The mechanisms of remodeling are largely unclear. To dissect molecular cellular in CKD an unbiased fashion, we performed left ventricular single-nuclear RNA sequencing two mouse models CKD. Our data showed a hypertrophic response trajectory cardiomyocytes stress signaling metabolic changes driven by soluble uremia-related factors. We mapped fibroblast to myofibroblast...
The identification of differences in protein expression resulting from methodical variations is an essential component to the interpretation true, biologically significant results.We used Lowry and Bradford methods- two most commonly methods for quantification, assess whether differential expressions are a result true biological or variations. MATERIAL #ENTITYSTARTX00026;Differential patterns was assessed by western blot following quantification methods.We have observed concentrations...
The kidney normally functions to maintain hemodynamic homeostasis and is a major site of damage caused by drug toxicity. Drug-induced nephrotoxicity estimated contribute 19- 25% all clinical cases acute injury (AKI) in critically ill patients. AKI detection has historically relied on metrics such as serum creatinine (sCr) or blood urea nitrogen (BUN) which are demonstrably inadequate full assessment the early phase renal dysfunction. Currently, there no robust diagnostic method accurately...
25-hydroxyvitamin D can undergo C-3 epimerization to produce 3-epi-25(OH)D3. 3-epi-25(OH)D3 levels decline in chronic kidney disease (CKD), but its role regulating the cardiovascular system is unknown. Herein, we examined relationship between 3-epi-25(OH)D3, and functional structural endpoints patients with CKD.
Background The myocardial cytoskeleton functions as the fundamental framework critical for organelle function, bioenergetics and remodeling. To date, impairment of occurring in failing heart patients with advanced chronic kidney disease has been largely undescribed. Methods Results We conducted a 3‐arm cross‐sectional cohort study explanted human tissues from who are dependent on hemodialysis (n=19), hypertension (n=10) preserved renal healthy controls (n=21). Left ventricular were subjected...
AimsVascular calcification (VC) is a significant contributor to cardiovascular mortality in patients with chronic kidney disease (CKD) and coronary artery (CAD). Osteo/chondrocytic transformation simultaneous dedifferentiation of smooth muscle cells (SMCs) are important the pathogenesis VC. Heat-shock protein 72 (HSP72) cardioprotective inducible heat-shock that functions as molecular chaperone. However, its role development accelerated vascular dysfunction largely unexplored.
Fibroblast growth factor 23 (FGF23) is a bone-derived phosphatonin that elevated in chronic kidney disease (CKD) and has been implicated the development of cardiovascular disease. It unknown whether FGF23 CKD associated with impaired functional capacity, as assessed by maximum exercise oxygen consumption (VO
Nonapnea sleep disorders (NASDs) and associated problems, which are highly prevalent in patients with kidney diseases, unfavorable medical sequelae. Nonetheless, whether NASDs acute injury (AKI) development has not been thoroughly analyzed. We examined the association between NASD AKI. conducted a population-based study by using 1,000,000 representative data from Taiwan National Health Insurance Research Database for period January 1, 2000, to December 31, 2010. studied incidence risk of AKI...
Significance Statement Kidney endothelial cells are sensitive to hypoxic injury. This cell type expresses integrin α 5 (ITGA5), which is essential the Tie2 signaling cascade. The microRNA miR-218 known increase after hypoxia, but microRNA’s role in regulating ITGA5 protein synthesis unclear. In this study, authors found that miR-218-5p specifically binds mRNA human kidney-derived progenitor (EPCs). an animal model of ischemia/reperfusion injury, pretreated with mimic were delivered...
The kidney normally functions to maintain hemodynamic homeostasis and is a major site of damage caused by drug toxicity. Drug-induced nephrotoxicity estimated contribute 19- 25% all clinical cases acute injury (AKI) in critically ill patients. AKI detection has historically relied on metrics such as serum creatinine (sCr) or blood urea nitrogen (BUN) which are demonstrably inadequate full assessment the early phase renal dysfunction. Currently, there no robust diagnostic method accurately...