A5100351309- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Advanced MRI Techniques and Applications
- Cancer-related molecular mechanisms research
- Advanced Neuroimaging Techniques and Applications
- Receptor Mechanisms and Signaling
- S100 Proteins and Annexins
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Hair Growth and Disorders
- Neurological Disease Mechanisms and Treatments
Union Hospital
2017-2025
Guangzhou Development Zone Hospital
2022-2025
Shandong University
2015-2025
Fujian Medical University
2014-2025
University of California, Irvine
2015-2025
China Pharmaceutical University
2023-2025
Wenzhou Medical University
2012-2025
Dongyang People's Hospital
2021-2025
Shandong Provincial Hospital
2022-2025
Shandong First Medical University
2025
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed mammals. We discovered mouse that during wound healing, adipocytes regenerate from myofibroblasts, a type thought be differentiated nonadipogenic. Myofibroblast required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling then activation adipocyte transcription factors expressed development. Overexpression BMP antagonist Noggin...
Although metastasis is the leading cause of cancer-related death, it not clear why some patients with localized cancer develop metastatic disease after complete resection their primary tumor. Such relapses have been attributed to tumor cells that disseminate early and remain dormant for prolonged periods time; however, little known about control these disseminated cells. Here, we used a spontaneous mouse model melanoma investigate cell dissemination immune outgrowth. Tumor were found...
In order to metastasize, cancer cells need acquire a motile phenotype. Previously, development of this phenotype was thought rely on the acquisition selected, random mutations and thus would occur late in progression. However, recent studies show that disseminate early, implying existence different, faster route metastatic Using spontaneous murine model melanoma, we subset bone marrow-derived immune (myeloid-derived suppressor or MDSC) preferentially infiltrates primary tumor actively...
Abstract Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and central nervous system malformations, which are outcomes broadly referred as the Congenital Syndrome (CZS). Here we infect pregnant rhesus macaques investigate impact persistent ZIKV on uteroplacental pathology, blood flow, development. Despite seemingly normal fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects placental oxygen...
The combined health impact of physical activity (PA) and air pollution on chronic obstructive pulmonary disease (COPD) remains unclear. We investigated the joint effects habitual PA long-term fine particulate matter (PM
Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine consist lipid-filled cells called lipochondrocytes. Despite resembling adipocytes, lipochondrocytes were molecularly distinct produced lipids exclusively through de novo lipogenesis. Consequently, grew uniform lipid droplets resisted systemic surges did not enlarge upon obesity. Lipochondrocytes also lacked mobilization factors,...
Regulation of adaptive immunity by innate immune cells is widely accepted. Conversely, can also regulate the system. Here, we report for first time essential role B in regulating macrophage (Mφ) phenotype. In vitro cell/Mφ co-culture experiments together with transgenic mice models B-cell deficiency or overexpression showed B1 to polarize Mφ a distinct This was characterized downregulated TNF-α, IL-1β and CCL3, but upregulated IL-10 upon LPS stimulation; constitutive expression M2 markers...
Oral direct‐acting antivirals (DAAs) represent a major advance in hepatitis C virus (HCV) treatment. Along with recent updates HCV screening policy and expansions insurance coverage, treatment demand the United States is changing rapidly. Our objective was to project characteristics number of people needing antiviral HCV‐associated disease burden era oral DAAs. We used previously developed validated Hepatitis Disease Burden Simulation model (HEP‐SIM). HEP‐SIM simulated actual clinical...
Growth factors are involved in the regulation of hair morphogenesis and cycle growth. The present study sought to investigate growth promoting activities three approved factor drugs, fibroblast 10 (FGF-10), acidic (FGF-1), basic (FGF-2), mechanism action. We observed that FGFs promoted by inducing anagen phase telogenic C57BL/6 mice. Specifically, histomorphometric analysis data indicates topical application induced an earlier prolonged mature phase, contrast control group. Moreover,...
Abstract Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial hold considerable promise for treatment DN. In this study, we investigated role progranulin (PGRN), secreted glycoprotein, mediating homeostasis and its therapeutic potential We found that level PGRN was significantly reduced kidney from STZ-induced mice patients with biopsy-proven DN compared healthy controls. model,...
Abstract MCL1 is a pivot member of the anti-apoptotic BCL-2 family proteins. While distinctive feature resides in its efficient ubiquitination and destruction, deubiquitinase USP9X has been implicated preservation expression by removing polyubiquitin chains. Here we perform an unbiased siRNA screen identify that second deubiquitinase, USP13, regulates stability lung ovarian cancer cells. Mechanistically, USP13 interacts with stabilizes via deubiquitination. As result, depletion using...
Summary Aim To investigate the mechanism of endoplasmic reticulum (ER) stress–induced apoptosis as well protective action basic fibroblast growth factor ( bFGF ) both in vivo and vitro . Methods Results ER was involved injuries spinal cord injury (SCI) model rat. administration improved recovery increased survival neurons lesions The effect is related to inhibition CHOP, GRP78 caspase‐12, which are response proteins. also expression growth‐associated protein 43 (GAP43), neural regeneration....
Clinicopathological paradox has hampered significantly the effective assessment of efficacy therapeutic intervention for multiple sclerosis. Neuroimaging biomarkers tissue injury could guide more treatment by accurately reflecting underlying subclinical pathologies. Diffusion tensor imaging‐derived directional diffusivity and anisotropy indices have been applied to characterize white matter disorders. However, these are sometimes confounded complex pathologies seen in sclerosis its animal...
Although tissue-resident-memory T (TRM) cells, a recently identified non-circulating memory cell population, play crucial role in mediating local immune responses and protect against pathogens upon reinfection, the composition, effector function, specificity of TRM cells kidney their relevance for chronic disease remain unknown. In this study, we found that renal tissue displayed high abundance tissue-resident lymphocytes, proportion CD8+ was significantly increased from patients mice with...
Abstract Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the HDAC isoforms and underlying mechanism that are involved G2/M of TECs remain unclear. Here, we find Hdac9 expression is significantly induced mouse fibrotic kidneys, especially proximal tubules, aristolochic acid nephropathy (AAN) or unilateral ureter obstruction (UUO). Tubule-specific deletion HDAC9 pharmacological inhibition TMP195 attenuates cell G2/M, then...
Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi human often display excessive hair growth, suggesting cell hyperactivity. Here, using genetic mouse models of nevi2,3, we show that dermal clusters senescent melanocytes drive epithelial exit and change their transcriptome composition, potently enhancing renewal. Nevus distinct...
Abstract Capturing circulating tumor cells (CTCs) in vivo from the bloodstream lessens metastasis and recurrence risks. However, absence of CTC receptors due to epithelial‐mesenchymal transition (EMT), limited binding capacity a single ligand, complexity blood flow environment significantly reduce efficiency capture vivo. Herein, multivalent ligand‐decorated microsphere enrichment system (MLMES) is crafted that incorporates column replete with an immunosorbent precisely recognizes binds...