A5070416455- RNA Research and Splicing
- Rabies epidemiology and control
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- Helicobacter pylori-related gastroenterology studies
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Galectins and Cancer Biology
- Virus-based gene therapy research
- Animal Genetics and Reproduction
- Viral Infections and Vectors
- Ubiquitin and proteasome pathways
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- Cancer Cells and Metastasis
- Poxvirus research and outbreaks
- RNA Interference and Gene Delivery
- Veterinary medicine and infectious diseases
- Cancer-related molecular mechanisms research
- Microbial infections and disease research
- Epigenetics and DNA Methylation
South China Agricultural University
2016-2025
China Pharmaceutical University
2022-2025
South China Normal University
2025
Southwest Forestry University
2023-2024
State Forestry and Grassland Administration
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Stomatological Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
State Key Laboratory of Natural Medicine
2023
Chinese Academy of Sciences
2022
Abstract Capturing circulating tumor cells (CTCs) in vivo from the bloodstream lessens metastasis and recurrence risks. However, absence of CTC receptors due to epithelial‐mesenchymal transition (EMT), limited binding capacity a single ligand, complexity blood flow environment significantly reduce efficiency capture vivo. Herein, multivalent ligand‐decorated microsphere enrichment system (MLMES) is crafted that incorporates column replete with an immunosorbent precisely recognizes binds...
Porcine epidemic diarrhea (PED) virus (PEDV) is one of the main pathogens causing in piglets and fattening pigs. The clinical signs PED are vomiting, acute diarrhea, dehydration, mortality resulting significant economic losses becoming a major challenge pig industry. PEDV possesses various crucial structural functional proteins, which play important roles viral structure, infection, replication, assembly, release, as well escaping host innate immunity. Over past few years, there has been...
Ganoderma lucidum (G. lucidum) extracts, as dietary supplements, have been found to exert potent anticancer activity, which is attributed the presence of polysaccharides and triterpenes. However, molecular mechanism underlying action G. extracts remains be investigated. Here, we show that ReishiMax GLp, containing triterpenes (GLPT), inhibited cell proliferation induced death in human lung cancer cells (A549 A427) simultaneously suppressed signaling pathways mammalian target rapamycin...
ObjectiveTo investigate the dynamic characteristics of serological antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is much current significance.MethodsThe changes and prevalence immunoglobulin M (IgM) G (IgG) SARS-CoV-2 were assessed from time symptom onset up to 210 days. Antibodies detected using a chemiluminescence immunoassay.ResultsThe average titers IgG/IgM positivity rates reached peak within 30 days then began decline continuously. Between 180...
Chronic stress poses threats to the physical and psychological well-being of dogs. Resveratrol (Res) is a polyphenol with antidepressant properties has rarely been studied in This study aimed investigate stress-relieving effects underlying mechanism Res Dogs were fed basal diet supplemented for 35 days. The fecal microbiota dogs was cultured vitro. results show that improved stress-related behaviors increased serum levels 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF),...
Purpose: This study aimed to evaluate the effectiveness of cognitive-behavioral therapy (CBT)-based peer support groups in preventing smartphone dependence among Chinese migrant children. Methods: Using a nonrandomized pretest–posttest design, 60 participants ( Mage = 13.92, SD 1.39, 68.3% female) were assigned intervention (n 30) and control groups. The consisted CBT-based sessions. Results: Analysis was by intention-to-treat. 2 × 3 mixed repeated measures analysis variance indicated...
The epitope vaccine is an attractive potential for prophylactic and therapeutic vaccination against Helicobacter pylori (H. pylori) infection. Lpp20 one of major protective antigens which trigger immune response after H. invades host has been considered as excellent candidate the control In our previous study, B-cell two CD4(+) T-cell epitopes were identified.In this composed mucosal adjuvant cholera toxin B subunit (CTB) these three identified constructed to investigate efficacy in mice.The...
Tripartite motif (TRIM) proteins are a multifunctional E3 ubiquitin ligase family that participates in various cellular processes. Recent studies have shown TRIM play important roles regulating host-virus interactions through specific pathways, but their involvement response to rabies virus (RABV) infection remains poorly understood. Here, we identified several upregulated mouse neuroblastoma cells (NA) after with the using RNA-seq sequencing. Among them, TRIM44 was found regulate RABV...
Several studies have demonstrated the rabies virus to be a perfect potential vaccine vector insert foreign genes into target genome. For this study, green fluorescent protein (GFP) gene was cloned (RABV) genome between N and P gene. CT dinucleotide inserted as intergenic region. The recombinant high egg passage Flury strain (HEP-Flury) of RABV, carrying GFP (rHEP-NP-GFP), generated in BHK-21 cells using reverse genetics. According viral growth kinetics assay, addition has little effect on...
Rabies remains a great threat to public health worldwide. So far, the mechanism of rabies virus (RABV) infection is not fully understood, and there no effective treatment for rabies. Identifying more host restriction factors RABV will spur development novel therapeutic interventions against Accumulating studies suggest that tripartite motif-containing (TRIM) proteins have effects on replication. TRIMs control antiviral responses through either direct interaction with viral or indirect...
Rabies, caused by rabies virus (RABV), is a zoonotic disease infecting mammals including humans. Studies have confirmed that glycoprotein (G) most related to RABV pathogenicity. In the present study, discover more amino acid sites viral pathogenicity, artificial mutants been constructed in G of virulent strain GD-SH-01 backbone. Results showed pathogenicity significantly decreased when Gly349 was replaced Glu349 through vivo assays. Gly349→Glu349 did not influence growth and spread NA cells....
AIM:To detect and evaluate the antibodies against Helicobacter pylori (H ) neutrophil-activating protein (HP-NAP) in patients with gastric cancer other gastroduodenal diseases. METHODS:Recombinant HP-NAP was prepared from a prokaryotic expression system Escherichia coli .Serum positivity level of HP-NAP-specific sera 43 cancer, 28 chronic gastritis, peptic ulcer, 89 healthy controls were measured by rHP-NAP-based ELISA.rHP-NAP-stimulated production interleukin-8 (IL-8) growth-related...
Rabies virus (RABV) matrix (M) protein plays several important roles during RABV infection. Although previous studies have assessed the functions of M through gene rearrangements, this interferes with position other viral proteins. In study, we attenuated expression deoptimizing its codon usage based on pair bias in RABV. This strategy more objectively clarifies role Codon-deoptimized inhibited replication early stages infection, but enhanced titers at later stages. also genome synthesis...
Rabies, a highly fatal zoonotic disease, is significant global public health threat. Currently, the pathogenic mechanism of rabies has not been fully elucidated, and no effective treatment for available. Increasing evidence shows that tripartite-motif protein (TRIM) family proteins participates in host’s regulation viral replication. Studies have demonstrated upregulated expression 21 (TRIM21) brain tissue mice infected with virus. Related studies shown TRIM21 knockdown inhibits RABV...