A5100456307- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Selenium in Biological Systems
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Trace Elements in Health
- Folate and B Vitamins Research
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Nutritional Studies and Diet
- Acute Ischemic Stroke Management
- Magnetism in coordination complexes
- Organic and Molecular Conductors Research
- Cardiac electrophysiology and arrhythmias
- Chronic Kidney Disease and Diabetes
- Hormonal Regulation and Hypertension
Peking University First Hospital
2016-2025
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Weifang People's Hospital
2025
Hebei Medical University
2017-2025
Second Hospital of Hebei Medical University
2017-2025
Affiliated Hospital of Qingdao University
2019-2025
Jiangnan University
2024-2025
Xi'an Jiaotong University
2022-2025
Xi'an Honghui Hospital
2022-2025
Summary Leaf nitrogen and phosphorus stoichiometry of Chinese terrestrial plants was studied based on a national data set including 753 species across the country. Geometric means were calculated for functional groups life form, phylogeny photosynthetic pathway, as well all species. The relationships between leaf N P stoichiometric traits latitude (and temperature) analysed. geometric N, P, : ratio 18.6 1.21 mg g −1 14.4, respectively. With increasing (decreasing mean annual temperature,...
<h3>Importance</h3> Uncertainty remains about the efficacy of folic acid therapy for primary prevention stroke because limited and inconsistent data. <h3>Objective</h3> To test hypothesis that with enalapril is more effective in reducing first than alone among Chinese adults hypertension. <h3>Design, Setting, Participants</h3> The China Stroke Primary Prevention Trial, a randomized, double-blind clinical trial conducted from May 19, 2008, to August 24, 2013, 32 communities Jiangsu Anhui...
A number of noninvasive techniques have been used to predict the effectiveness cardiac resynchronization therapy (CRT) in heart failure patients, particular left ventricular (LV) reverse remodeling. This study compared relative predictive values tissue Doppler imaging (TDI) and strain-rate (SRI) parameters for LV remodeling patients who received CRT examined potential differences ischemic (n=22) nonischemic (n=32) failure.TDI SRI were performed at baseline 3-month follow-up. Eighteen...
Efficacy of potential treatments for myocardial infarction (MI) is commonly assessed by histological measurement infarct size in rodent models. In experiments involving an acute MI setting, the infarcted area tissue sections left ventricle a standard approach to determine size. This has also been used chronic setting measure several weeks post-MI. We tested hypothesis that, because wall thinning known occur would be less appropriate. compared measurements based on 1) area, 2) epicardial and...
Background Selenium is an essential trace element in mammals due to its presence proteins the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing protein genes, and mouse rat genomes 24. Methodology/Principal Findings We characterized selenoproteomes 44 sequenced vertebrates by applying gene prediction phylogenetic reconstruction methods, supplemented with analyses structures, alternative splicing isoforms, untranslated regions, SECIS elements, pseudogenes. In total, we...
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, GPX6 (glutathione peroxidases), DIO1, DIO2, DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), SEPHS2 (selenophosphate synthetase...
Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and the 21st amino acid genetic code. However, means by which Sec synthesized eukaryotes not known. Herein, comparative genomics experimental analyses revealed that mammalian synthase (SecS) previously identified pyridoxal phosphate-containing known as soluble liver antigen. SecS required selenophosphate O-phosphoseryl-tRNA[Ser]Sec substrates generate selenocysteyl-tRNA[Ser]Sec. Moreover, it was found...
Analogs of vitamin D attenuate renal injury in several models kidney disease, but the mechanism underlying this renoprotective effect is unknown. To address role receptor (VDR) fibrogenesis, we subjected VDR-null mice to unilateral ureteral obstruction for 7 days. Compared with wild-type mice, developed more severe damage obstructed kidney, marked tubular atrophy and interstitial fibrosis. Significant induction extracellular matrix proteins (fibronectin collagen I), profibrogenic...
Objectives We sought to determine the prognostic value of left ventricular (LV) mitral annular velocities measured by tissue Doppler imaging (TDI) in hypertensive patients with echocardiographic evidence LV hypertrophy. Background Echo hypertrophy and geometry provide additional predictive all-cause mortality beyond traditional cardiovascular risk factors. Limited data exist regarding TDI for stratification treated patients. Methods Two-dimensional echocardiograms were obtained 252...
Selenocysteine (Sec) is a selenium-containing amino acid that co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both eukaryotes and prokaryotes, but the selenoprotein content of organisms (selenoproteome) highly variable some do not utilize Sec at all. We analyzed selenoproteomes several model detected 26 29 genes green algae Ostreococcus tauri lucimarinus, respectively, five social amoebae Dictyostelium discoideum, three fly Drosophila...
Copper is an essential trace element in many organisms and utilized all domains of life. It often used as a cofactor redox proteins, but also toxic metal ion. Intracellular copper must be carefully handled to prevent the formation reactive oxygen species which pose threat DNA, lipids, proteins. In this work, we examined patterns utilization prokaryotes by analyzing occurrence transporters copper-containing Many organisms, including those that lack copper-dependent had exporters, likely...
Although dietary selenium (Se) deficiency results in phenotypes associated with selenoprotein depletion various organs, the brain is protected from Se loss. To address basis for critical role of function, we carried out comparative gene expression analyses complete selenoproteome and biosynthetic factors. Using Allen Brain Atlas, evaluated 159 regions adult mouse provided experimental selected selenoproteins. All 24 mRNAs were expressed brain. Most strikingly, neurons olfactory bulb,...
COVID-19 is the current public health threat all over world. Unfortunately, there no specific prevention and treatment strategy for this disease. We aim to explore potential role of angiotensin-converting enzyme 2 (ACE2) in regard through literature review. As a crucial renin-angiotensin-aldosterone system (RAAS), ACE2 not only mediates virus entry but also affects pathophysiological process virus-induced acute lung injury (ALI), as well other organs' damage. interaction spike essential...
Abstract Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant analysis on 65,671 single nucleotide polymorphisms reveals 19 associated with at significance ( P <2.69 × 10 −7 ), including three Asian-specific coding variants in known genes CETP p.Asp459Gly, PCSK9 p.Arg93Cys and...
Background: Platelets from patients with diabetes mellitus are hyperactive. Hyperactivated platelets may contribute to cardiovascular complications and inadequate responses antiplatelet agents in the setting of mellitus. However, underlying mechanism hyperactivated is not completely understood. Methods: We measured P2Y 12 expression on type 2 rats also assayed platelet activation by measuring cAMP VASP phosphorylation. The antithrombotic effects AR-C78511 cangrelor were compared rats....