Min‐Lee Yang
A5055361304- RNA modifications and cancer
- MicroRNA in disease regulation
- Renal and Vascular Pathologies
- Cardiovascular Issues in Pregnancy
- Erythrocyte Function and Pathophysiology
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Coronary Artery Anomalies
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Pulmonary Hypertension Research and Treatments
- Blood groups and transfusion
- Genomic variations and chromosomal abnormalities
- Cardiac Structural Anomalies and Repair
- Epigenetics and DNA Methylation
- Machine Learning in Bioinformatics
- Vascular anomalies and interventions
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- Connective Tissue Growth Factor Research
- Molecular Biology Techniques and Applications
- Hemoglobinopathies and Related Disorders
- Abdominal vascular conditions and treatments
University of Michigan
2015-2025
Michigan Medicine
2014-2024
Michigan United
2024
Milligan College
2019
Chang Gung Memorial Hospital
2011
Chang Gung University
2011
Abstract Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant analysis on 65,671 single nucleotide polymorphisms reveals 19 associated with at significance ( P <2.69 × 10 −7 ), including three Asian-specific coding variants in known genes CETP p.Asp459Gly, PCSK9 p.Arg93Cys and...
Abstract Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook genome-wide association study SCAD (N cases = 270/N controls 5,263) and identified replicated an rs12740679 at chromosome 1q21.2 ( P discovery+replication 2.19 × 10 −12 , OR 1.8) influencing ADAMTSL4 expression. Meta-analysis discovery replication samples associations with < 5 −8 6p24.1 PHACTR1 12q13.3 LRP1 females-only, 21q22.11 near...
Fibromuscular dysplasia (FMD) is a rare, nonatherosclerotic arterial disease for which the molecular basis unknown. We comprehensively studied 47 subjects with FMD, including physical examination, spine magnetic resonance imaging, bone densitometry, and brain angiography. Inflammatory biomarkers in plasma transforming growth factor β (TGF-β) cytokines patient-derived dermal fibroblasts were measured by ELISA. Arterial pathology other than medial fibrodysplasia multifocal stenosis included...
Objective: While rare variants in the COL5A1 gene have been associated with classical Ehlers-Danlos syndrome and rarely arterial dissections, recurrent underlying a systemic arteriopathy not described. Monogenic forms of multifocal fibromuscular dysplasia (mFMD) previously defined. Approach Results: We studied 4 independent probands pathogenic variant c.1540G>A, p.(Gly514Ser) who presented aneurysms, tortuosity, mFMD affecting multiple arteries. Arterial medial fibroplasia smooth muscle...
Copy number variations (CNVs), a major source of human genetic polymorphism, have been suggested to an important role in susceptibility common diseases such as cancer, immune and neurological disorders. Nasopharyngeal carcinoma (NPC) is multifactorial tumor closely associated with background male preponderance over female (3:1). Previous genome-wide association studies identified single-nucleotide polymorphisms (SNPs) that are NPC susceptibility. Here, we sought explore the possible CNVs...
Background: The risk of arterial diseases may be elevated among family members individuals having multifocal fibromuscular dysplasia (FMD). We sought to investigate the in families with FMD. Methods: Family histories for 73 probands FMD were obtained, which included an analysis 463 total first-degree relatives focusing on and related disorders. A polygenic score (PRS ) was constructed from prior genome-wide association findings 584 cases 7139 controls evaluated abdominal aortic aneurysm...
Abstract Aims Fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection (SCAD) are related, non-atherosclerotic arterial diseases mainly affecting middle-aged women. Little is known about their physiopathological mechanisms. We aimed to identify rare genetic causes elucidate molecular mechanisms implicated in FMD SCAD. Methods results analysed 29 exomes that included familial sporadic FMD. identified one loss-of-function variant (LoF) (frequencygnomAD = 0.000075) shared by two...
Background Research studies of spontaneous coronary artery dissection (SCAD) have been primarily focused on European‐ancestry individuals, with limited recognition and investigation in non–European‐ancestry individuals. While SCAD has not well ascertained groups, pleiotropic associated traits identified those European ancestry assessed individuals other ancestries. Whether these are the complex genetic architecture non‐European previously investigated. Methods We investigated associations an...
Abstract Spontaneous coronary artery dissection (SCAD) is a potential precipitant of myocardial infarction and sudden death for which the etiology poorly understood. Mendelian vascular connective tissue disorders underlying thoracic aortic disease (TAD), have been reported in ~5% individuals with SCAD. We therefore hypothesized that patients TAD are at elevated risk queried registries enrolling to define incidence Of 7568 enrolled, 11 (0.15%) were found sequenced cases (9/11), pathogenic...
Genetic studies of blood pressure (BP) traits to date have been performed on conventional measures by brachial cuff sphygmomanometer for systolic BP (SBP) and diastolic BP, integrating several physiologic occurrences. associations with central SBP (cSBP) not well-studied. discovery most often in European-ancestry samples. Here, we investigated genetic cSBP a Chinese population functionally validated the impact novel associated coiled-coil domain containing 93 ( CCDC93 ) gene regulation. An...
Genomic discovery efforts for hematological traits have been successfully conducted through genome-wide association study on samples of predominantly European ancestry. We sought to conduct unbiased genetic coding variants that influence in a Han Chinese population. A total 5257 subjects from Beijing, China were included the cohort and analyzed by an Illumina ExomeChip array. Replication analyses 3827 independent subjects. 12 identified 22 exome-wide significant single-nucleotide...
Abstract The etiology of renal artery stenosis (RAS) and abdominal aortic coarctation (AAC) causing the midaortic syndrome (MAS), often resulting in renovascular hypertension (RVH), remains ill-defined. Neurofibromatosis type 1 (NF-1) is frequently observed children with RVH. Consecutive pediatric patients (N = 102) presenting RVH secondary to RAS without concurrent AAC were prospectively enrolled a clinical data base, blood, saliva operative tissue, when available, collected. Among 102...
Abstract Spontaneous coronary artery dissection (SCAD) is an understudied cause of acute myocardial infarction primarily affecting women. It not known to what extent SCAD genetically distinct from other cardiovascular diseases, including atherosclerotic disease (CAD). Through a meta-analysis genome-wide association studies 1917 cases and 9292 controls European ancestry, we identified 17 risk loci, 12 new, with odds ratios ranging 2.04 (95%CI 1.77-2.35) on chr21 1.25 1.16-1.35) chr4. A locus...
Abstract Objective: Fibromuscular dysplasia (FMD) is an arteriopathy that presents mainly by hypertension, stroke or dissection. Diagnosis often made in middle-aged women with few cardiovascular risk factors. We aim at identifying common genetic variants associated to FMD. Design and method: tested ∼6.5 million (MAF > 0.01) 1962 cases 7100 controls from 6 studies using gene-based association analyses. Participants were of European ancestry, similar characteristics (91% multifocal, 88%...
Abstract Nasopharyngeal carcinoma (NPC) is a multi-factorial malignancy closely associated with genetic factors and Epstein-Barr virus infection. Recently, we have conducted genome-wide association study (GWAS) in 277 NPC patients 285 healthy controls within the Taiwanese population, analyzing 480,365 single-nucleotide polymorphisms (SNPs). Twelve statistically significant SNPs were identified mapped to chromosome 6p21.3 major histocompatibility complex region. In addition HLA-A gene,...
<p>PDF file, 6233K, S1: Inference of Aneuploid Genome Proportion and its goodness-of-fit measures; Figure S2: Histolopathological estimates tumor purities versus AGP; S3: Relationship between AGP gene expression pattern in ovarian cancer (OV); S4: PCA plots for CNA CNA-MicroRNA joint analysis; S5: Principal component analyses data GBM2; S6: Clustering three types: PC1 copy number data, PC2 methylation data; S7: Classification Non-Proneural GBM tumors; S8: Cross-correlation analysis...
<p>PDF file, 323K.</p>