A5058198453- Aortic aneurysm repair treatments
- Genetic Associations and Epidemiology
- Nitric Oxide and Endothelin Effects
- Aortic Disease and Treatment Approaches
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Apelin-related biomedical research
- MicroRNA in disease regulation
- Connective tissue disorders research
- Lipid metabolism and disorders
- Infectious Aortic and Vascular Conditions
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Coronary Interventions and Diagnostics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
Stanford University
2016-2025
Cardiovascular Institute of the South
2015-2025
VA Palo Alto Health Care System
2016-2025
Beth Israel Deaconess Medical Center
2024
Universitätsklinikum Würzburg
2024
Universitätsmedizin Göttingen
2024
Palo Alto University
2008-2024
The Coordinating Center
2021-2024
Philadelphia VA Medical Center
2024
National Taiwan University Hospital
2024
Background —Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase. Because endothelial NO elaboration impaired in hypercholesterolemia, we investigated whether plasma concentrations ADMA are elevated young, clinically asymptomatic hypercholesterolemic adults. We further studied such elevation levels was correlated with endothelium-dependent, NO-mediated vasodilation and urinary nitrate excretion. In a randomized, double-blind,...
The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in diagnosis, genetic evaluation family screening, medical therapy, endovascular surgical treatment, long-term surveillance patients with aortic disease across its multiple clinical presentation subsets (ie, asymptomatic, stable symptomatic, acute syndromes).
The purpose of this study was to determine the efficacy stent-based delivery sirolimus (SRL) alone or in combination with dexamethasone (DEX) reduce in-stent neointimal hyperplasia. SRL is a potent immunosuppressive agent that inhibits SMC proliferation by blocking cell cycle progression.Stents were coated nonerodable polymer containing 185 microgram SRL, 350 DEX, and DEX. Polymer biocompatibility studies porcine canine models showed acceptable tissue response at 60 days. Forty-seven stents...
The purpose of this study was to determine if chronic administration L-arginine, the precursor endothelium-derived relaxing factor (EDRF), normalizes endothelium-dependent relaxation and decreases atherosclerosis in hypercholesterolemic animals. Male rabbits were fed (a) normal rabbit chow; (b) 1% cholesterol diet; or (c) diet supplemented by 2.25% L-arginine HCl drinking water. Arginine supplementation doubled plasma arginine levels without affecting serum values. After 10 wk, thoracic...
An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the mechanisms by which ADMA becomes DM.Male Sprague-Dawley rats were fed normal chow or high-fat diet (n=5 each) moderate streptozotocin injection to induce DM. Plasma was diabetic (1.33+/-0.31 versus 0.48+/-0.08 micromol/L; P<0.05). The activity, but not expression, dimethylaminohydrolase (DDAH) reduced and negatively...
Background Hyperhomocysteinemia is a putative risk factor for cardiovascular disease, which also impairs endothelium-dependent vasodilatation. A number of other factors disease may exert their adverse vascular effects in part by elevating plasma levels asymmetric dimethylarginine (ADMA), an endogenous inhibitor nitric oxide synthase. Accordingly, we determined if homocysteine could increase ADMA levels. Methods and Results When endothelial or nonvascular cells were exposed to DL-homocysteine...
Epigenetic biomarkers of aging (the "epigenetic clock") have the potential to address puzzling findings surrounding mortality rates and incidence cardio-metabolic disease such as: (1) women consistently exhibiting lower than men despite having higher levels morbidity; (2) racial/ethnic groups different even after adjusting for socioeconomic differences; (3) black/white cross-over effect in late adulthood; (4) Hispanics United States a longer life expectancy Caucasians burden traditional risk...
Background —Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). Plasma levels ADMA are elevated in individuals with hypercholesterolemia or atherosclerosis. We postulated that reduced degradation may play a role the accumulation these individuals. Accordingly, we studied effects oxidized LDL (oxLDL) tumor necrosis factor-α (TNF-α) on by transformed human umbilical vein endothelial cells (ECV304) and enzyme dimethylaminohydrolase (DDAH), which...
Aging | doi:10.18632/aging.101168. Austin Quach, Morgan E. Levine, Toshiko Tanaka, Ake T. Lu, Brian H. Chen, Luigi Ferrucci, Beate Ritz, Stefania Bandinelli, Marian L. Neuhouser, Jeannette M. Beasley, Linda Snetselaar, Robert B. Wallace, Philip S. Tsao, Devin Absher, Themistocles Assimes, James D. Stewart, Yun Li, Lifang Hou, Andrea A. Baccarelli, Eric Whitsel, Steve Horvath
There is increasing evidence that alterations in nitric oxide synthesis are of pathophysiological importance heart failure. A number studies have shown altered production by the endothelial constitutive isoform synthase (NOS), but there very little information on role inducible isoform.We analyzed NOS (iNOS) expression ventricular myocardium taken from 11 control subjects (who had died suddenly noncardiac causes), 10 donor hearts before implantation, and 51 patients with failure (24 dilated...
Myocardial ischemia and reperfusion have been shown to impair coronary vasorelaxation endothelium-dependent vasodilators. To examine the time course of this dysfunction, occlusion left anterior descending (LAD) artery (90 minutes) was followed by for 0, 2.5, 5, 20, 180, or 270 minutes. Coronary arterial rings from ischemic LAD control circumflex (LCx) arteries were tested responsiveness receptor-mediated vasodilator, acetylcholine (ACh), nonreceptor-mediated A23187, as well...
Abstract —Diabetes mellitus (DM) is a primary risk factor for cardiovascular disease. Although recent studies have demonstrated an important role extracellular matrix metalloproteinases (MMPs) in atherosclerosis, little known about the effects of hyperglycemia on MMP regulation vascular cells. Gelatin zymography and Western blot analysis revealed that activity expression 92-kDa (MMP-9) gelatinase, but not 72 kDa (MMP-2) were significantly increased tissue plasma two distinct rodent models...
Abstract Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Use Disorder Identification Test-Consumption (AUDIT-C) scores AUD diagnoses in a multi-ancestry Million Veteran Program sample ( N = 274,424). identify 18 significant loci: 5 associated with both traits, 8 AUDIT-C only, only. Polygenic Risk Scores (PRS) for alcohol-related disorders two independent samples....
Apelin and its cognate G protein–coupled receptor APJ constitute a signaling pathway with positive inotropic effect on cardiac function vasodepressor in the systemic circulation. The apelin-APJ appears to have opposing physiological roles renin-angiotensin system. Here we investigated whether can directly antagonize vascular disease-related Ang II actions. In ApoE-KO mice, exogenous induced atherosclerosis abdominal aortic aneurysm formation; found that coinfusion of apelin abrogated these...
MicroRNAs (miRs) regulate gene expression at the posttranscriptional level and play crucial roles in vascular integrity. As such, they may have a role modifying abdominal aortic aneurysm (AAA) expansion, pathophysiological mechanisms of which remain incompletely explored. Here, we investigate miRs 2 murine models experimental AAA: porcine pancreatic elastase (PPE) infusion model C57BL/6 mice AngII Apoe-/- mice. AAA development was accompanied by decreased miR-29b, along with increased known...