Karl‐Heinz Herzig
A5030462166- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Vitamin D Research Studies
- Muscle metabolism and nutrition
- Obesity, Physical Activity, Diet
- Helicobacter pylori-related gastroenterology studies
- Cystic Fibrosis Research Advances
- Birth, Development, and Health
- Pancreatic and Hepatic Oncology Research
- Diabetes Treatment and Management
- Stress Responses and Cortisol
- Exercise and Physiological Responses
- Diet, Metabolism, and Disease
- Circadian rhythm and melatonin
- Neuroendocrine Tumor Research Advances
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
Oulu University Hospital
2015-2024
University of Oulu
2015-2024
Poznan University of Medical Sciences
2004-2024
Istanbul Kent University
2024
Imperial College London
2022-2024
Singapore Institute for Clinical Sciences
2022
Agency for Science, Technology and Research
2022
Kuopio University Hospital
2007-2021
University Hospital Schleswig-Holstein
2005-2020
University of Lübeck
2005-2020
Key points Contradictory findings have been reported concerning the function of irisin and its precursor gene, skeletal muscle FNDC5 , in energy homeostasis metabolic health, associated regulatory role exercise PGC‐1α . We analysed effects different short‐ long‐term regimens on serum irisin, studied associations with health parameters. did not change after acute aerobic, endurance training or combined resistance (RE) training, associate disturbances. A single RE bout increased mRNA young,...
Abstract Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric N ordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods conducted a randomized dietary study lasting for 18–24 weeks individuals features syndrome (mean age 55 years, BMI 31.6 kg m −2 , 67% women). Altogether 309 were screened, 200 started intervention after 4‐week run‐in period, 96...
Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due bias. In order examine altered genetically predicted concentration of circulating cytokines associated with development, we performed a two-sample Mendelian randomisation (MR) analysis.
In this study, Prokopenko and colleagues provide novel evidence for causal relationship between adiposity heart failure increased liver enzymes using a Mendelian randomization study design. Please see later in the article Editors' Summary
Anemia is common in colorectal cancer (CRC) but its relationships with tumor characteristics, systemic inflammation, and survival have not been well characterized. In this study, blood hemoglobin levels erythrocyte mean corpuscular volume (MCV) were measured two independent cohorts of 148 CRC patients 208 patients, their correlation patient inflammatory markers (modified Glasgow Prognostic Score: mGPS; serum thirteen cytokines, C-reactive protein, albumin), analyzed. We found that anemia,...
A subset of colorectal cancers (CRCs) exhibits so‐called Crohn's like lymphoid reaction (CLR), an inflammatory pattern that consists numerous transmural aggregates. However, the composition these aggregates, their biological mechanisms and prognostic significance are not well‐defined. We analyzed two CRC cohorts (418 149 patients) determined clinicopathological features including survival. new method for evaluating CLR based on counting areal density follicles (CLR density) was adopted....
Obesity is a major public health problem, predisposing subjects to metabolic syndrome, type 2 diabetes, and cardiovascular diseases. Specific prolyl 4-hydroxylases (P4Hs) regulate the stability of hypoxia-inducible factor (HIF), potent governor metabolism, with isoenzyme being main regulator. We investigated whether HIF-P4H-2 inhibition could be used treat obesity its consequences. Hif-p4h-2–deficient mice, fed normal chow or high-fat diet, had less adipose tissue, smaller adipocytes, tissue...
Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation a potential mediator of this relationship. examined the association prenatal maternal blood in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization mediation analyses assess whether markers have causal effects on disease offspring. identify 69 differentially methylated CpGs 36...
Abstract Grey wolves ( Canis lupus ) are one of the few large terrestrial carnivores that have maintained a wide geographical distribution across Northern Hemisphere throughout Pleistocene and Holocene. Recent genetic studies suggested that, despite this continuous presence, major demographic changes occurred in wolf populations between Late early Holocene, extant trace their ancestry to single population. Both origin ancestral population how it became widespread remain unknown. Here, we...
Abstract Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels alanine transaminase (ALT), alkaline phosphatase (ALP) gamma-glutamyl transferase (GGT) using data 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent the Million Veteran Program, Rotterdam Study Lifeline study confirms 517 enzyme SNPs. Genetic risk score identified SNPs is strongly associated...
Abstract We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted islands. genomic predominantly transcription factor binding enhancer regions. Mendelian...