A5038985491- Animal Behavior and Reproduction
- Plant and animal studies
- Genetics, Aging, and Longevity in Model Organisms
- Evolutionary Psychology and Human Behavior
- Insect and Arachnid Ecology and Behavior
- Evolution and Genetic Dynamics
- Genetic and phenotypic traits in livestock
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Insect behavior and control techniques
- Gynecological conditions and treatments
- Spaceflight effects on biology
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Neuroendocrine regulation and behavior
- Reproductive Biology and Fertility
- Demographic Trends and Gender Preferences
- Sexuality, Behavior, and Technology
- CRISPR and Genetic Engineering
- Ovarian function and disorders
- Sperm and Testicular Function
- Sexual function and dysfunction studies
- Crustacean biology and ecology
- Pregnancy and preeclampsia studies
- Physiological and biochemical adaptations
Janssen (United States)
2021-2025
Vanderbilt University Medical Center
2018-2024
Uppsala University
2015-2024
Johnson & Johnson (United States)
2023-2024
Vanderbilt University
2019-2023
University of Ottawa
2013-2020
Wilfrid Laurier University
2020
Australian National University
2009-2015
Zero to Three
2011
Illinois State University
2008
Compelling evidence from many animal taxa indicates that male genitalia are often under postcopulatory sexual selection for characteristics increase a male’s relative fertilization success. There could, however, also be direct precopulatory female mate choice based on genital traits. Before clothing, the nonretractable human penis would have been conspicuous to potential mates. This observation has generated suggestions size partly evolved because of choice. Here we show, upon assessment...
Sexual selection is a major force behind the rapid evolution of male genital morphology among species. Most within-species studies have focused on sexual traits owing to events during or after copulation that increase male's share paternity. Very little attention has been given whether genitalia are visual signals cause males vary in their attractiveness females and therefore under pre-copulatory selection. Here we show that, average, female eastern mosquitofish Gambusia holbrooki spent more...
Evolutionary theory of ageing maintains that increased allocation to early-life reproduction results in reduced somatic maintenance, which is predicted compromise longevity and late-life reproduction. This prediction has been challenged by the discovery long-lived mutants with no loss fecundity. The first such mutant was found nematode worm Caenorhabditis elegans Specifically, partial loss-of-function mutation age-1 gene, involved nutrient-sensing insulin/insulin-like growth factor...
Abstract Background The burden of comorbidities in those with uterine fibroids compared to without is understudied. We performed a phenome-wide association study systematically assess the between and other conditions. Methods Vanderbilt University Medical Center’s Synthetic Derivative Geisinger Health System Database, two electronic health record databases, were used for discovery validation. Non-Hispanic Black White females included. Fibroid cases identified through previously validated...
Recent studies suggest that males might respond in an adaptive manner to elevated likelihood of male–male competition for mates by facultatively altering their mating preferences. Little is known, however, about how male choice influenced a male's relative competitiveness or the risk posed increased physical access compared with greater sperm competition. We investigated size and presence competitor influences using 2-choice experiments mosquito fish, Gambusia holbrooki. varied focal male,...
Abstract Germline regulates the expression of life‐history traits and mediates trade‐off between reproduction somatic maintenance. However, germline maintenance in itself can be costly, costs vary sexes depending on number gametes produced across lifetime. We tested this directly by ablation using glp‐1 RNA interference (RNAi) a dioecious nematode Caenorhabditis remanei . removal strongly increased heat‐shock resistance both sexes, thus confirming role regulating resulted lifespan only...
Few studies have simultaneously compared ageing within genetically similar populations in both laboratory and natural environments. Such comparisons are important for interpreting studies, because factors such as diet could affect environment-dependent ways. Using a population of antler flies (Protopiophila litigata), we conducted separate factorial experiments 2012 2013 that age-specific male survival mating success cages versus field environment while supplementing their diets with protein...
Abstract Dietary restriction (DR) is a well-established intervention to extend lifespan across taxa. Recent studies suggest that DR-driven extension can be cost-free, calling into question central tenant of the evolutionary theory aging. Nevertheless, boosting parental longevity reduce offspring fitness. Such intergenerational trade-offs are often ignored but account for “missing costs” longevity. Here, we use nematode Caenorhabditis remanei test effects DR by fasting on fitness females and...
Males of many species defend resources to attract females. Surprisingly, defense multiple female breeding sites (e.g., nests or burrows) appears be rare, primarily reported in fish and birds. In fiddler crabs, burrows are a vital resource for reproduction survival. Both sexes individual territories centered on single burrow. We examined burrow acquisition Uca capricornis test whether males as novel strategy acquire additional mates. When crabs were experimentally forced new burrow, females...
High-quality developmental environments often improve individual performance into adulthood, but allocating toward early life traits, such as growth, development rate and reproduction, may lead to trade-offs with late-life performance. It is, therefore, uncertain how a rich environment will affect the ageing process (senescence), particularly in wild insects. To investigate effects of environmental quality on insect life-history including senescence, we reared larval antler flies (...
Abstract The placenta is critical to human growth and development has been implicated in health outcomes. Understanding the mechanisms through which influences perinatal later-life outcomes requires further investigation. We evaluated relationships between birthweight adult body mass index (BMI) genetically-predicted gene expression placenta. Birthweight genome-wide association summary statistics were obtained from Early Growth Genetics Consortium (N = 298,142). Adult BMI GIANT consortium...
Female crickets can exert post-copulatory mating preferences by prematurely removing a male's spermatophore after copulation, which terminates sperm transfer. Although most models of sexual selection assume that female are heritable, there has been little work addressing genetic variation underlying mate choice. We used paternal half-sib design, in different males were randomly assigned as mates to several females create families, determine the heritability retention time house crickets,...
Abstract Germline regulates the expression of life-history traits and mediates trade-off between reproduction somatic maintenance. However, germline maintenance in itself can be costly, costs vary sexes depending on number gametes produced across lifetime. We tested this directly by ablation using glp-1 RNAi a dioecious nematode Caenorhabditis remanei . removal strongly increased heat-shock resistance both sexes, thus confirming role regulating resulted lifespan only males. High mating...
Abstract Reproduction between individuals from different ancestral populations creates genetically admixed offspring. Admixture can have positive and negative impacts on individual health, feeding back to population health. Historical forced migrations, recent mobility, brought formerly disparate of humans together. Here we sought better understand how temporal changes in genetic admixture influence levels heterozygosity health outcomes. We evaluated variation ancestry over 100 birth years...
Many researchers in genetics and social science incorporate information about race their work. However, migrations (historical forced) mobility have brought formerly separated populations of humans together, creating younger generations individuals who more complex diverse ancestry profiles than older age groups. Here, we sought to better understand how temporal changes genetic admixture influence levels heterozygosity impact health outcomes. We evaluated variation over 100 birth years a...