John Concato
A5001817812- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Obstructive Sleep Apnea Research
- Prostate Cancer Treatment and Research
- Statistical Methods in Clinical Trials
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Posttraumatic Stress Disorder Research
- Neuroscience of respiration and sleep
- Cerebrovascular and Carotid Artery Diseases
- Respiratory Support and Mechanisms
- Cardiovascular and Diving-Related Complications
- Alcohol Consumption and Health Effects
- Advanced Causal Inference Techniques
- Substance Abuse Treatment and Outcomes
- Asthma and respiratory diseases
- Lipoproteins and Cardiovascular Health
- Global Cancer Incidence and Screening
- Cardiovascular Health and Risk Factors
- Meta-analysis and systematic reviews
- Colorectal Cancer Screening and Detection
- Bipolar Disorder and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Healthcare Policy and Management
Yale University
2016-2025
Center for Drug Evaluation and Research
2020-2024
United States Food and Drug Administration
2021-2024
VA Connecticut Healthcare System
2012-2021
VA Connecticut Research and Education Foundation
1995-2021
United States Department of Veterans Affairs
2002-2020
University of Cincinnati
2020
Cincinnati Children's Hospital Medical Center
2020
VA Boston Healthcare System
2015-2019
Harvard University
2019
We performed a Monte Carlo study to evaluate the effect of number events per variable (EPV) analyzed in logistic regression analysis. The simulations were based on data from cardiac trial 673 patients which 252 deaths occurred and seven variables cogent predictors mortality; predictive was () for full sample. For simulations, at values EPV = 2, 5, 10, 15, 20, 25, we randomly generated 500 samples patients, chosen with replacement, according model derived Simulation results coefficients each...
Previous studies have suggested that the obstructive sleep apnea syndrome may be an important risk factor for stroke. It has not been determined, however, whether is independently related to of stroke or death from any cause after adjustment other factors, including hypertension.In this observational cohort study, consecutive patients underwent polysomnography, and subsequent events (strokes deaths) were verified. The diagnosis was based on apnea-hypopnea index 5 higher (five more per hour);...
The analytical effect of the number events per variable (EPV) in a proportional hazards regression analysis was evaluated using Monte Carlo simulation techniques for data from randomized trial containing 673 patients and 252 deaths, which seven predictor variables had an original significance level p < 0.10. deaths 7 correspond to 36 analyzed full set. Five hundred simulated analyses were conducted these at EPVs 2, 5, 10, 15, 20, 25. For each simulation, random exponential survival time...
ObjectiveTo describe the design and ongoing conduct of Million Veteran Program (MVP), as an observational cohort study mega-biobank in Department Veterans Affairs (VA) health care system.Study Design SettingData are being collected from participants using questionnaires, VA electronic record, a blood sample for genomic other testing. Several projects linked to MVP, both peer-reviewed research studies activities help develop infrastructure future, broad-based uses.ResultsFormal planning MVP...
Abstract Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Use Disorder Identification Test-Consumption (AUDIT-C) scores AUD diagnoses in a multi-ancestry Million Veteran Program sample ( N = 274,424). identify 18 significant loci: 5 associated with both traits, 8 AUDIT-C only, only. Polygenic Risk Scores (PRS) for alcohol-related disorders two independent samples....
<h3>Hypothesis</h3> Good preoperative glycemic control (hemoglobin A<sub>1c</sub>[HbA<sub>1c</sub>] levels <7%) is associated with decreased postoperative infections. <h3>Design</h3> Retrospective observational study using Veterans Affairs National Surgical Quality Improvement Program data from the Connecticut Healthcare System January 1, 2000, through September 30, 2003. <h3>Setting</h3> System, a tertiary referral center and major university teaching site. <h3>Patients</h3> Six hundred...
Anxiety disorders are common and often disabling. The goal of this study was to examine the genetic architecture anxiety symptoms, which also frequently comorbid with other mental disorders, such as major depressive disorder.
Background Obstructive sleep apnoea (OSA) is a heterogeneous disorder, and improved understanding of physiologic phenotypes their clinical implications needed. We aimed to determine whether routine polysomnographic data can be used identify OSA (clusters) assess the associations between cardiovascular outcomes. Methods Cross-sectional longitudinal analyses multisite, observational US Veteran (n=1247) cohort were performed. Principal components-based clustering was features in OSA’s four...
The Million Veteran Program (MVP), initiated by the Department of Veterans Affairs (VA), aims to collect biosamples with consent from at least one million veterans. Presently, blood samples have been collected over 800,000 enrolled participants. size and diversity MVP cohort, as well availability extensive VA electronic health records, make it a promising resource for precision medicine. is conducting array-based genotyping provide genome-wide scan entire in parallel whole-genome sequencing,...
ABSTRACT Aims Gender differences exist regarding alcohol and illicit drug use disorders in the United States. Little is known about gender‐related factors associated with non‐medical of prescription opioids. Design Using data from 2003 National Survey on Drug Use Health, we examined risk for past‐year opioids stratified by gender. Setting Non‐institutionalized US residences. Participants Civilian, non‐institutionalized citizens aged 12 years older. Measurements Self‐reported use, focusing...
New approaches are needed to treat patients with stroke. Among acute ischemic stroke patients, our primary objectives were describe the prevalence of sleep apnea and demonstrate feasibility providing auto-titrating continuous positive airway pressure (auto-CPAP). A secondary objective was examine effect auto-CPAP on severity. Stroke randomized intervention group received 2 nights auto-CPAP, but only those evidence for remainder 30-day period. Intervention polysomnography 30 days post-stroke....
Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction AAA heritability.We performed genome-wide association study in the Million Veteran Program testing ≈18 million DNA sequence variants with (7642 cases and 172 controls) veterans European ancestry independent replication up to 4972 99 858 controls. We then used mendelian...