A5027729792- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- COVID-19 Pandemic Impacts
- HIV/AIDS drug development and treatment
- Bone health and osteoporosis research
- HIV Research and Treatment
- Emergency and Acute Care Studies
- Liver Disease Diagnosis and Treatment
- Healthcare Policy and Management
- Menopause: Health Impacts and Treatments
- HIV-related health complications and treatments
- Thyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Marine animal studies overview
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- Cardiac Arrest and Resuscitation
- Thyroid Cancer Diagnosis and Treatment
- Bone health and treatments
- Diabetes Treatment and Management
- Cancer Risks and Factors
- Renal and Vascular Pathologies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Estrogen and related hormone effects
VA Palo Alto Health Care System
2016-2025
Georgetown University
2007-2025
Johns Hopkins University
2010-2024
Stanford University
2015-2024
Pain Management Institute
2023
Bellevue Hospital Center
2023
Stanford Medicine
2017-2023
Jacksonville College
2023
Mayo Clinic in Florida
2023
WinnMed
2023
High triglyceride (TG) levels and low HDL cholesterol (HDL-C) are risk factors for cardiovascular disease. It is unclear whether this relationship depends on glycemic dysregulation, sex, or LDL (LDL-C) level.We studied 3,216 participants (40% men, 41% with diabetes) who were free of disease at baseline in a community-based, prospective cohort American Indians (median follow-up 17.7 years). Cox models estimated hazard ratios (HRs) 95% CIs incident ischemic stroke coronary heart (CHD) relation...
Abstract The objective of this study was to describe the time onset and offset bone mineral density (BMD) loss relative date final menstrual period (FMP); rate amount BMD decline during 5 years before after FMP; independent associations between age at FMP, body mass index (BMI), race/ethnicity with rates interval. sample included 242 African American, 384 white, 117 Chinese, 119 Japanese women, pre- or early perimenopausal baseline, who had experienced their FMP for whom an could be...
Accurate measurement of low serum estradiol (E(2) < 30 pg/ml or 110 pmol/liter) is needed to study relationships between endogenous E(2) and risks diseases in older women.The objective this was determine whether an extraction-based (indirect) assay a non-extraction-based (direct) correlates better with mass spectrometry body index (BMI).In pilot 40 postmenopausal women, measurements from three indirect four direct methods gas chromatography-tandem (GC-MS/MS) were compared. A confirmatory...
Bone marrow stromal cells (BMSCs, also called bone-marrow-derived mesenchymal cells) provide hematopoietic support and immunoregulation contain a stem cell fraction capable of skeletogenic differentiation. We used immortalized human BMSC clonal lines for multi-level analysis functional markers subsets. All clones expressed typical cell-surface antigens; however, with trilineage differentiation capacity exhibited enhanced vascular interaction gene sets, whereas non-differentiating were...
<h3>Background</h3> Subclinical thyroid dysfunction is common in older adults and affects bone metabolism, but its effects on fracture risk have not been reported. We sought to determine prospectively whether men women with subclinical hyperthyroidism or hypothyroidism an increased of hip fracture. <h3>Methods</h3> Prospective cohort 3567 US community-dwelling adults, 65 years older, biochemically defined euthyroidism was enrolled from June 10, 1989, through May 30, 1990, followed up 2004....
Use of a single set thyroid function tests to define subclinical hypothyroidism may lead misclassification over time and could influence findings from longitudinal studies.We assessed the risks coronary heart disease (CHD), failure (HF), cardiovascular (CV) death in older adults with persistent hypothyroidism.The study included 679 subclinically hypothyroid 4184 euthyroid U.S. individuals at least 65 yr old enrolled Cardiovascular Health Study not taking preparations.We measured 10-yr risk...
Background: Obesity and the metabolic syndrome (MetS) have both been linked to increased risk of postmenopausal breast cancer; however, their relative contributions are poorly understood.Methods: We examined association phenotypes obesity defined by presence MetS (yes no) body mass index (BMI; normal, overweight, obese) with cancer in a prospective analysis cohort women (n ∼ 21,000) baseline measurements blood glucose, triglycerides, HDL-cholesterol, pressure, waist circumference, BMI. Women...
ACADEMIC EMERGENCY MEDICINE 2010; 17:813–823 © 2010 by the Society for Academic Emergency Medicine Abstract Objectives: The objective was to characterize service completion times patient, clinical, temporal, and crowding factors different phases of emergency care using quantile regression (QR). Methods: A retrospective cohort study conducted on 1‐year visit data from four academic departments (EDs; N = 48,896–58,316). From each ED’s clinical information system, authors extracted electronic...
Objective The recent identification of antigens or nucleic acids infectious agents in the joints patients with reactive arthritis has raised questions about whether chlamydial other agent are also present normal joints. We had opportunity to study synovium from 30 asymptomatic volunteer subjects by use polymerase chain reaction (PCR) for attempted Chlamydia and agents. Methods All blind needle synovial biopsies Parker-Pearson needle. DNA was extracted PCR performed using primers trachomatis,...
This article examines the extent and correlates of complementary alternative medicine (CAM) use among a population-based sample California adults that is highly diverse in terms sociodemographic characteristics health status. As follow-up to state-wide survey 55,428 people, 9187 respondents were interviewed by phone regarding their 11 different types CAM providers, special diets, dietary supplements, mind-body interventions, self-prayer support groups. The included all participants initial...
Endogenous estradiol, testosterone, and SHBG may influence the risk of hip fracture.From Women's Health Initiative Observational Study, 39,793 eligible postmenopausal women did not have a previous fracture were using estrogen or other bone-active therapies. Of these, 400 who had first-time nonpathological (median follow-up, 7 yr) matched to controls by age, ethnicity, baseline blood draw date. Estradiol, measured in banked serum.Compared with lowest tertiles, those bioavailable testosterone...
Abstract Background: Increased exposure to endogenous estrogen and/or insulin may partly explain the relationship of obesity, physical inactivity, and alcohol consumption postmenopausal breast cancer. However, these potential mediating effects have not been formally quantified in a survival analysis setting. Methods: We combined data from two case–cohort studies based Women's Health Initiative-Observational Study with serum estradiol levels, one which also had levels. A total 1,601 women...
Subclinical thyroid dysfunction is common in the elderly, yet its relationship with hip fracture and bone mineral density (BMD) unclear. We examined association between endogenous subclinical hyper- hypothyroidism BMD older adults. A total of 4936 US individuals 65 years old or enrolled Cardiovascular Health Study not taking preparations were included. Analyses incident performed by status, over a median follow-up 12 years. cross-sectional analysis status was subset 1317 participants who had...
Objectives: Preventing Loss of Independence through Exercise (PLIÉ) is a novel, integrative exercise program for individuals with dementia that combines elements different conventional and complementary modalities (e.g. tai-chi, yoga, Feldenkrais, dance movement therapy) focuses on training procedural memory basic functional movements (e.g., sit-to-stand) while increasing mindful body awareness facilitating social connection. This study presents analyses qualitative data collected during...
To describe the prevalence of diagnosed depression, anxiety, bipolar disorder, and schizophrenia in people with HIV (PWH) differences care continuum outcomes those without mental health disorders (MHDs).