A5000939681- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Ocular Diseases and Behçet’s Syndrome
- Innovations in Medical Education
- Clinical practice guidelines implementation
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Spondyloarthritis Studies and Treatments
- Vasculitis and related conditions
- Retinal and Optic Conditions
- Hepatitis C virus research
- Diversity and Career in Medicine
- Bone and Joint Diseases
- Health and Medical Research Impacts
- Health Policy Implementation Science
- Musculoskeletal Disorders and Rehabilitation
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Primary Care and Health Outcomes
- Radiology practices and education
- Skin Diseases and Diabetes
- Musculoskeletal synovial abnormalities and treatments
- Otitis Media and Relapsing Polychondritis
Weill Cornell Medical College in Qatar
2015-2025
Weill Cornell Medicine
2021
Cornell University
2019-2021
Hôtel-Dieu de France
2021
New York Medical College
2019
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2019
American University of Beirut
2002-2014
Duke-NUS Medical School
2014
American University of Beirut Medical Center
1999-2010
American University of Beirut New York Office
2007
Integrating genetic data from families with highly penetrant forms of disease together outbred populations represents a promising strategy to uncover the complete frequency spectrum risk alleles for complex traits such as rheumatoid arthritis (RA). Here, we demonstrate that rare, low-frequency and common at one gene locus, phospholipase B1 (PLB1), might contribute RA in 4-generation consanguineous pedigree (Middle Eastern ancestry) also unrelated individuals general population (European...
Abstract The diversity in our genome is crucial to understanding the demographic history of worldwide populations. However, we have yet know whether subtle genetic differences within a population can be disentangled, or they an impact on complex traits. Here apply dimensionality reduction methods (PCA, t -SNE, PCA- UMAP, and PCA-UMAP) biobank-derived genomic data Japanese ( n = 169,719). Dimensionality reveals fine-scale structure, conspicuously differentiating adjacent insular...
Background: Adaptation of existing guidelines can be an efficient way to develop contextualized recommendations. Transparent reporting the adaptation approach support transparency and usability adapted guidelines. Objective: To extension RIGHT (Reporting Items for practice Guidelines in HealThcare) statement (including recommendations that have been adopted, adapted, or developed de novo), RIGHT-Ad@pt checklist. Design: A multistep process was followed checklist: establishing a working...
Established in 2015, the Multi-Stakeholder Engagement (MuSE) Consortium is an international network of over 120 individuals interested stakeholder engagement research and guidelines. The MuSE group developing guidance for development health healthcare guideline development. this has included multiple meetings with stakeholders, including patients, payers/purchasers services, peer review editors, policymakers, program managers, providers, principal investigators, product makers, public,...
Objective The recent identification of antigens or nucleic acids infectious agents in the joints patients with reactive arthritis has raised questions about whether chlamydial other agent are also present normal joints. We had opportunity to study synovium from 30 asymptomatic volunteer subjects by use polymerase chain reaction (PCR) for attempted Chlamydia and agents. Methods All blind needle synovial biopsies Parker-Pearson needle. DNA was extracted PCR performed using primers trachomatis,...
Abstract Aim: To estimate the prevalence of rheumatic diseases in Lebanon and to explore their distribution by geographic location, age, gender. Method: Using Community Oriented Program for Control Rheumatic Diseases (COPCORD) methodology, a random sample 3530 individuals aged 15 above was interviewed from six Lebanese governorates. Positive respondents were evaluated rheumatologists using internationally accepted classification criterion American College Rheumatology diagnosis diseases....
Systemic inflammation in rheumatoid arthritis (RA) is associated with metabolic changes. We used nuclear magnetic resonance (NMR) spectroscopy-based metabolomics to assess the relationship between an objective measure of systemic [C-reactive protein (CRP)] and both serum urinary metabolome patients newly presenting RA.Serum (n=126) urine (n=83) samples were collected at initial presentation from disease modifying anti-rheumatic drug naïve RA for metabolomic profile assessment using...
Objective To assess the presence of Chlamydia pneumoniae DNA in joints patients with reactive arthritis (ReA) and other arthritides. Methods was prepared from synovial tissue (ST) several fluid (SF) samples 188 either ReA, undifferentiated oligoarthritis, or forms arthritis, 24 normal (nonarthritis) individuals. Preparations were screened using polymerase chain reaction (PCR) assays that independently targeted C 16S ribosomal RNA major outer membrane protein genes. Results Twenty-seven 212...
Objectives There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across Arab region. We aim in this study to describe demographic characteristics, clinical profile, patients ancestry with RA. Methods This a cross sectional 895 established enrolled from five sites (Jordan, Lebanon, Qatar, Kingdom Saudi Arabia (KSA), United Emirates). Demographic are compared between countries. Results The majority our women, have an average disease duration 10...
Due to the Covid-19 social distancing restrictions, in March 2020, Weill Cornell Medicine-Qatar decided replace students' clinical instruction with novel online electives. Hence, we implemented an innovative and remote pathology curriculum, anchored on virtual microscopy Zoom videoconferencing: ideal tools support teaching.To assess a new curriculum implementation at Medicine-Qatar.This for-credit, 2-week elective included 6 synchronous sessions where complex clinicopathological cases were...
To determine how HLA alleles are associated with the clinical disease patterns of patients synovitis recent onset.The A, B, C, DRbeta1, and DQbeta1 were determined in a cohort 211 (mean age 42 years, 64% female, 79% white) recent-onset 1 or more peripheral joints. At mean duration 33 weeks, 98 (46%) met American College Rheumatology (ACR) criteria for rheumatoid arthritis (RA), 38 (18%) European Spondylarthropathy Study Group spondylarthropathy (SpA), 75 (36%) classified as having...
<b>Objective:</b> To describe the immunohistochemical characteristics of knee synovium from normal healthy subjects. <b>Methods:</b> 12 subjects underwent needle biopsy synovium. Using antibodies directed against CD3, CD4, CD8, L26, Kp-1,and HLA-DR, detailed quantitative analysis various cell subpopulations was undertaken. <b>Results:</b> The mean (SD) age 37 (9) years (five male, seven female). All had a negative history for arthritis, no pain, and totally joint examination except presence...
It has been hypothesized that adaptation of health practice guidelines to the local setting is expected improve their uptake and implementation while cutting on required resources. We recently adapted published American College Rheumatology (ACR) Rheumatoid Arthritis (RA) treatment guideline Eastern Mediterranean Region (EMR). The objective this paper describe process used for 2015 ACR RA EMR. GRADE-Adolopment methodology process. in detail how adolopment enhanced efficiency following steps...
Abstract Background Health research teams increasingly partner with stakeholders to produce that is relevant, accessible, and widely used. Previous work has covered stakeholder group identification. Objective We aimed develop factors for health consider during identification invitation of individual representatives in a multi-stakeholder partnership, the aim forming equitable informed teams. Design Consensus development. Participants involved 16 from international Multi-Stakeholder...