A5043048253- Meta-analysis and systematic reviews
- Cancer Treatment and Pharmacology
- Health Systems, Economic Evaluations, Quality of Life
- Breast Cancer Treatment Studies
- Ethics in Clinical Research
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Clinical practice guidelines implementation
- Delphi Technique in Research
- Breast Lesions and Carcinomas
- Primary Care and Health Outcomes
- Health and Medical Research Impacts
- Health Policy Implementation Science
- Obesity, Physical Activity, Diet
- Health Sciences Research and Education
- Lung Cancer Research Studies
- Chemotherapy-related skin toxicity
- Pharmaceutical industry and healthcare
- Patient-Provider Communication in Healthcare
- Global Cancer Incidence and Screening
- Palliative Care and End-of-Life Issues
- Statistical Methods in Clinical Trials
- Patient Dignity and Privacy
- Healthcare cost, quality, practices
- Cancer therapeutics and mechanisms
National Health and Medical Research Council
2015-2024
The University of Sydney
2008-2024
Monash University
2024
Respiratory Clinical Trials
2007-2017
World Health Organization
2007-2012
World Health Organization - Pakistan
2008-2011
Cooperative Trials Group for Neuro-Oncology
2005-2008
Sir Charles Gairdner Hospital
2007
The University of Western Australia
2007
Westmead Hospital
2003-2007
Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of review; few report whether exists. Detailed, well-described protocols can facilitate understanding appraisal review methods, as well detection modifications to selective reporting in completed reviews. We describe development guideline, Preferred Reporting Items for Meta-Analyses Protocols 2015 (PRISMA-P 2015). PRISMA-P consists 17-item checklist intended preparation robust...
Protocols of systematic reviews and meta-analyses allow for planning documentation review methods, act as a guard against arbitrary decision making during conduct, enable readers to assess the presence selective reporting completed reviews, and, when made publicly available, reduce duplication efforts potentially prompt collaboration. Evidence documenting existence excessive on same or similar topics is accumulating many calls have been in support public availability protocols. Several...
In systematic reviews and meta-analyses, time-to-event outcomes are most appropriately analysed using hazard ratios (HRs). the absence of individual patient data (IPD), methods available to obtain HRs and/or associated statistics by carefully manipulating published or other summary data. Awareness adoption these is somewhat limited, perhaps because they in statistical literature notation.
Following publication of the PRISMA statement, UK Centre for Reviews and Dissemination (CRD) at University York in England began to develop an international prospective register systematic reviews with health-related outcomes. The objectives were reduce unplanned duplication provide transparency review process, aim minimizing reporting bias. An advisory group was formed a consultation undertaken establish key items necessary inclusion gather views on various aspects functionality. This...
In 2017, the Australian Government funded update of National Physical Activity Recommendations for Children 0–5 years, with intention that they be an integration movement behaviours across 24-h period. The benefit Australia was it could leverage research in Canada development their guidelines early years. Concurrently, Grading Assessment, Development and Evaluation (GRADE) working group published a model to produce based on adoption, adaption and/or de novo using GRADE evidence-to-decision...
Extenuating circumstances can trigger unplanned changes to randomized trials and introduce methodological, ethical, feasibility, analytical challenges that potentially compromise the validity of findings. Numerous have required in response COVID-19 pandemic, but guidance for reporting such modifications is incomplete.As a joint extension CONSORT SPIRIT guidelines, CONSERVE (CONSORT Extension RCTs Revised Circumstances) aims improve trial protocols completed undergo important extenuating...
Abstract Background Stakeholder engagement has become widely accepted as a necessary component of guideline development and implementation. While frameworks for developing guidelines express the need those potentially affected by recommendations to be involved in their development, there is lack consensus on how this should done practice. Further, guidance equitably meaningfully engage multiple stakeholders. We aim develop meaningful equitable stakeholders Methods This will multi-stage...
Abstract Background In 2018, the Australian Government updated Physical Activity and Sedentary Behaviour Guidelines for Children Young People. A requirement of this update was incorporation a 24-hour approach to movement, recognising importance adequate sleep. The purpose paper describe how 24-Hour Movement People (5 17 years): an integration physical activity, sedentary behaviour sleep were developed outcomes from process . Methods GRADE-ADOLOPMENT used develop guidelines. Leadership Group...
study protocolThe methods section in a protocol should provide description of the intervention(s) (whether active, usual practice, or placebo) that is sufficiently detailed to enable people with appropriate expertise reproduce them.This include:• What were "contents," including all constituent components, materials, and resources their quality • Who delivered intervention, expertise, additional training, support Where intervention was (the setting) How when delivered: dose, schedule...
Objectives We examined major issues associated with sharing of individual clinical trial data and developed a consensus document on providing access to participant from trials, using broad interdisciplinary approach. Design methods This was consensus-building process among the members multistakeholder task force, involving wide range experts (researchers, patient representatives, methodologists, information technology experts, representatives funders, infrastructures standards development...
Lack of transparency in clinical trial conduct, publication bias and selective reporting are still important problems medical research. Through trials registration, it should be possible to take steps towards resolving some these problems. However, previous evaluations registered records have shown that information is often incomplete non-meaningful. If studies accurate, this negates the benefits registration trials.
Introduction The benefits of clinical trials registration include improved transparency on for healthcare workers and patients, increased accountability trialists, the potential to address publication bias selective reporting, possibilities research collaboration prioritization. However, poor quality information in registered records has been found undermine these past. Trialists' increasing experience with trial recent developments systems may have positively affected data quality. This...