A5035361085- Web Data Mining and Analysis
- Research Data Management Practices
- Advanced Computational Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Power Systems and Technologies
- Service-Oriented Architecture and Web Services
- Video Analysis and Summarization
- Web and Library Services
- Genetic Mapping and Diversity in Plants and Animals
- Digital Rights Management and Security
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Distributed and Parallel Computing Systems
- Semantic Web and Ontologies
- Atmospheric and Environmental Gas Dynamics
- Genomics and Chromatin Dynamics
- Advanced Sensor and Control Systems
- Superconducting Materials and Applications
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- RNA Research and Splicing
- Antimicrobial Resistance in Staphylococcus
- interferon and immune responses
- Immune Cell Function and Interaction
University of Central Florida
2019-2025
Florida College
2022-2025
First Hospital of Jiaxing
2025
Jiaxing University
2025
Stanford University
2017-2024
Pennsylvania State University
2020-2024
Nanchang University
2022-2024
Affiliated Hospital of Nantong University
2020-2023
Nantong University
2020-2023
Versus Arthritis
2023
Mammalian genomes have multiple enhancers spanning an ultralong distance (>megabases) to modulate important genes, but it is unclear how these coordinate achieve this task. We combine multiplexed CRISPRi screening with machine learning define quantitative enhancer-enhancer interactions. find that the enhancer network has a nested multilayer architecture confers functional robustness of gene expression. Experimental characterization reveals epistasis maintained by three-dimensional...
Bayesian methods for large-scale multiple regression provide attractive approaches to the analysis of genome-wide association studies (GWAS). For example, they can estimate heritability complex traits, allowing both polygenic and sparse models; by incorporating external genomic data into priors, increase power yield new biological insights. However, these require access individual genotypes phenotypes, which are often not easily available. Here we a framework performing analyses without...
Abstract Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary component. Here, we report genome-wide association study that included 1,122 PBC cases and 4,036 controls of Han Chinese descent, subsequent replication in separate cohort 907 2,127 controls. Our results show 14 risk loci including previously identified 6p21 ( HLA-DRA DPB1 ), 17q12 ORMDL3 3q13.33 CD80 2q32.3 STAT1 / STAT4 3q25.33 IL12A 4q24 NF-κB ) 22q13.1 RPL3 SYNGR1 ). We also variants IL21 ,...
Abstract Genome-wide association studies (GWAS) aim to identify genetic factors associated with phenotypes. Standard analyses test variants for associations individually. However, variant-level are hard and can be difficult interpret biologically. Enrichment help address both problems by targeting sets of biologically related variants. Here we introduce a new model-based enrichment method that requires only GWAS summary statistics. Applying this interrogate 4,026 gene in 31 human phenotypes...
Abstract High-altitude adaptation of Tibetans represents a remarkable case natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting pressing need to understand the functional role regulatory elements (REs). Here, we generate time courses paired ATAC-seq and RNA-seq data on cultured HUVECs hypoxic normoxic conditions. We further develop variant interpretation methodology (vPECA) identify active selected REs (ASREs)...
Abstract Huntington disease (HD) is a fatal neurodegenerative caused by pathogenic expansion of CAG repeat in the huntingtin (HTT) gene. There are no disease-modifying therapies for HD. Artificial microRNAs targeting HTT transcripts degradation have shown preclinical promise and will soon enter human clinical trials. Here, we examine tolerability efficacy non-selective lowering with an AAV5 encoded miRNA (AAV5-miHTT) humanized Hu128/21 mouse model We show that intrastriatal administration...
Osteoarthritis (OA) has been recognized as the most common chronic age-related disease. Cartilage degeneration influences OA therapy. Here we report that hematopoietic pre-B cell leukemia transcription factor-interacting protein (HPIP) is essential for development. Elevated HPIP levels are found in patients. Col2a1-CreERT2/HPIPf/f mice exhibit obvious skeletal abnormalities compared with their HPIPf/f littermates. deficiency protects against developing OA. Moreover, intra-articular injection...
Abstract Background The vast majority of findings from human genome-wide association studies (GWAS) map to non-coding sequences, complicating their mechanistic interpretations and clinical translations. Non-coding sequences that are evolutionarily conserved biochemically active could offer clues the mechanisms underpinning GWAS discoveries. However, genetic effects such have not been systematically examined across a wide range tissues traits, hampering progress fully understand regulatory...
Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide. These tumors originate from epithelial cells of upper aerodigestive tract. HNSCC in different regions can have significantly molecular characteristics. While many microRNAs (miRNAs) been found to be involved regulation carcinogenesis pathogenesis HNSCC, new related miRNAs are still being discovered. The aim this study was explore potential miRNA biomarkers that used diagnose prognose survival patients....
Abstract DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has poorly understood genetic basis. To systematically identify regulators of timing, we exploited inter-individual variation in human pluripotent stem cells from 349 individuals. We show the genome’s is broadly encoded and 1,617 cis -acting timing quantitative trait loci (rtQTLs) – sequence determinants initiation. rtQTLs function individually, or combinations proximal distal...
Genome-wide association studies (GWAS) have cataloged many significant associations between genetic variants and complex traits. However, most of these findings unclear biological significance, because they often small effects occur in non-coding regions. Integration GWAS with gene regulatory networks addresses both issues by aggregating weak signals within programs. Here we develop a Bayesian framework that integrates summary statistics to infer enrichments simultaneously. Our method...
Recent studies have demonstrated the remarkable potential of early life intervention strategies at influencing course postnatal development, thereby offering exciting possibilities for enhancing longevity and improving overall health. Metformin (MF), an FDA-approved medication type II diabetes mellitus, has recently gained attention its promising anti-aging properties, acting as a calorie restriction mimetic, delaying precocious puberty. Additionally, trodusquemine (MSI-1436),...
Anti‐nuclear antibodies to speckled 100 kDa (sp100) and glycoprotein 210 (gp210) are specific serologic markers of primary biliary cholangitis (PBC) uncertain/controversial clinical or prognostic significance. To study the genetic determinants associated with sp100 gp210 autoantibody subphenotypes, we performed a genome‐wide association analysis 930 PBC cases based on their status, followed by replication in 1,252 cases. We confirmed single‐nucleotide polymorphisms rs492899 ( P = 3.27 × 10...